Lazy learning is a memory-based technique that, once a query is received, extractsa prediction interpolating locally the neighboring examples of the query which are considered relevant according to a distance measure. In this paper we propose a data-driven method to select on a query-by-query basis the optimal number of neighbors to be considered for each prediction. As an efficient way to identify and validate local models, the recursive least squares algorithm is introduced in the context oflocal approximation and lazy learning. Furthermore, beside the winner-takes-all strategy for model selection, a local combination of the most promising models is explored. The method proposed is tested on six different datasets and compared with a state-of-the-art approach.

We discuss the application of TAP mean field methods known from the Statistical Mechanics of disordered systems to Bayesian classification modelswith Gaussian processes. In contrast to previous approaches, noknowledge about the distribution of inputs is needed. Simulation results for the Sonar data set are given. They have been recently introduced into the Neural Computation community (Neal 1996, Williams & Rasmussen 1996, Mackay 1997). If we assume fields with zero prior mean, the statistics of h is entirely defined by the second order correlations C(s, S') E[h(s)h(S')], where E denotes expectations 310 MOpper and 0. Winther with respect to the prior. Interesting examples are C(s, s') (1) C(s, s') (2) The choice (1) can be motivated as a limit of a two-layered neural network with infinitely many hidden units with factorizable input-hidden weight priors (Williams 1997).

Based on a simple convexity lemma, we develop bounds for different typesof Bayesian prediction errors for regression with Gaussian processes. The basic bounds are formulated for a fixed training set. Simpler expressions are obtained for sampling from an input distribution whichequals the weight function of the covariance kernel, yielding asymptotically tight results. The results are compared with numerical experiments.

We describe a unifying method for proving relative loss bounds for online linearthreshold classification algorithms, such as the Perceptron and the Winnow algorithms. For classification problems the discrete loss is used, i.e., the total number of prediction mistakes. We introduce a continuous lossfunction, called the "linear hinge loss", that can be employed to derive the updates of the algorithms. We first prove bounds w.r.t. the linear hinge loss and then convert them to the discrete loss. We introduce anotion of "average margin" of a set of examples . We show how relative loss bounds based on the linear hinge loss can be converted to relative loss bounds i.t.o. the discrete loss using the average margin.

Gaussian process (GP) prediction suffers from O(n3) scaling with the data set size n. By using a finite-dimensional basis to approximate the GP predictor, the computational complexity can be reduced. We derive optimalfinite-dimensional predictors under a number of assumptions, andshow the superiority of these predictors over the Projected Bayes Regression method (which is asymptotically optimal). We also show how to calculate the minimal model size for a given n. The calculations are backed up by numerical experiments.

We solve the dynamics of Hopfield-type neural networks which store sequences ofpatterns, close to saturation. The asymmetry of the interaction matrix in such models leads to violation of detailed balance, ruling out an equilibrium statistical mechanical analysis. Using generating functional methods we derive exact closed equations for dynamical order parameters, viz.the sequence overlap and correlation and response functions.

Here we derive measures quantifying the information loss of a synaptic signal due to the presence of neuronal noise sources, as it electrotonically propagates along a weakly-active dendrite. We model the dendrite as an infinite linear cable, with noise sources distributed along its length. The noise sources we consider are thermal noise, channel noise arising from the stochastic nature of voltage-dependent ionic channels (K and Na) and synaptic noise due to spontaneous background activity. We assess the efficacy of information transfer using a signal detection paradigm where the objective is to detect the presence/absence of a presynaptic spike from the post-synaptic membrane voltage. This allows us to analytically assess the role of each of these noise sources in information transfer. For our choice of parameters, we find that the synaptic noise is the dominant noise source which limits the maximum length over which information be reliably transmitted. 1 Introduction This is a continuation of our efforts (Manwani and Koch, 1998) to understand the information capacityofa neuronal link (in terms of the specific nature of neural "hardware") by a systematic study of information processing at different biophysical stages in a model of a single neuron. Here we investigate how the presence of neuronal noise sources influences the information transmission capabilities of a simplified model of a weakly-active dendrite. The noise sources we include are, thermal noise, channel noise arising from the stochastic nature of voltage-dependent channels (K and Na) and synaptic noise due to spontaneous background activity. We characterize the noise sources using analytical expressions of their current power spectral densities and compare their magnitudes for dendritic parameters reported inliterature (Mainen and Sejnowski, 1998).

For example, a'Hebbian' (Hebb 1949) learning rule which is driven by the correlations between presynaptic and postsynaptic rates may be used to generate neuronal receptive fields (e.g., Linsker 1986, MacKay and Miller 1990, Wimbauer et al. 1997) with properties similar to those of real neurons. A rate-based description, however, neglects effects which are due to the pulse structure of neuronal signals.

Using a recurrent neural network of excitatory spiking neurons with adapting synapses we show that both effects could be explained by a fast and a slow component inthe synaptic adaptation.

On 30 October 1998, Mihaela Sabin and I ran the Constraint Problem Reformulation Workshop in conjunction with the Fourth International Conference on the Principles and Practices of Constraint Programming held in Pisa, Italy. The goals of the workshop were to discuss the nature of constraint problem reformulation and the benefits and difficulties in reformulating constraint problems and to summarize and understand the recent work in this area.