Recent experimental results suggest that dendritic and back-propagating spikes can influence synaptic plasticity in different ways [1]. In this study we investigate how these signals could temporally interact at dendrites leading to changing plasticity properties at local synapse clusters. Similar toa previous study [2], we employ a differential Hebbian plasticity rule to emulate spike-timing dependent plasticity. We use dendritic (D-) and back-propagating (BP-) spikes as post-synaptic signals in the learning ruleand investigate how their interaction will influence plasticity. We will analyze a situation where synapse plasticity characteristics change in the course of time, depending on the type of post-synaptic activity momentarily elicited.Starting with weak synapses, which only elicit local D-spikes, a slow, unspecific growth process is induced. As soon as the soma begins to spike this process is replaced by fast synaptic changes as the consequence of the much stronger and sharper BP-spike, which now dominates the plasticity rule. This way a winner-take-all-mechanism emerges in a two-stage process, enhancing the best-correlated inputs. These results suggest that synaptic plasticity is a temporal changing process bywhich the computational properties of dendrites or complete neurons canbe substantially augmented.

We present a probabilistic generative model of entity relationships and their attributes that simultaneously discovers groups among the entities and topics among the corresponding textual attributes. Block-models of relationship data have been studied in social network analysis for some time. Here we simultaneously cluster in several modalities at once, incorporating the attributes (here, words) associated with certain relationships. Significantly, joint inference allows the discovery of topics to be guided by the emerging groups, and vice-versa. We present experimental results on two large data sets: sixteen years of bills put before the U.S. Senate, comprising their corresponding text and voting records, and thirteen years of similar data from the United Nations. We show that in comparison with traditional, separate latent-variable models for words, or Block-structures for votes, the Group-Topic model's joint inference discovers more cohesive groups and improved topics.

Although nonparametric tests have already been proposed for that purpose, statisticalsignificance tests for nonstandard measures (different from the classification error) are less often used in the literature. This paper is an attempt at empirically verifying how these tests compare with more classical tests, on various conditions. More precisely, using a very large dataset to estimate the whole "population", we analyzed the behavior ofseveral statistical test, varying the class unbalance, the compared models, the performance measure, and the sample size. The main result isthat providing big enough evaluation sets nonparametric tests are relatively reliable in all conditions.

In this paper, we show that the hinge loss can be interpreted as the neg-log-likelihood of a semi-parametric model of posterior probabilities. From this point of view, SVMs represent the parametric component of a semi-parametric model fitted by a maximum a posteriori estimation procedure. Thisconnection enables to derive a mapping from SVM scores to estimated posterior probabilities. Unlike previous proposals, the suggested mappingis interval-valued, providing a set of posterior probabilities compatible with each SVM score. This framework offers a new way to adapt the SVM optimization problem to unbalanced classification, whendecisions result in unequal (asymmetric) losses. Experiments show improvements over state-of-the-art procedures.

Neurons can have rapidly changing spike train statistics dictated by the underlying network excitability or behavioural state of an animal. To estimate the time course of such state dynamics from single-or multiple neuronrecordings, we have developed an algorithm that maximizes the likelihood of observed spike trains by optimizing the state lifetimes and the state-conditional interspike-interval (ISI) distributions. Our nonparametric algorithmis free of time-binning and spike-counting problems and has the computational complexity of a Mixed-state Markov Model operating on a state sequence of length equal to the total number ofrecorded spikes. As an example, we fit a two-state model to paired recordings of premotor neurons in the sleeping songbird. We find that the two state-conditional ISI functions are highly similar to the ones measured duringwaking and singing, respectively.

We propose a new linear method for dimension reduction to identify non-Gaussian components in high dimensional data. Our method, NGCA (non-Gaussian component analysis), uses a very general semi-parametric framework. In contrast to existing projection methods we define what is uninteresting (Gaussian): by projecting out uninterestingness, we can estimate therelevant non-Gaussian subspace. We show that the estimation error of finding the non-Gaussian components tends to zero at a parametric rate.Once NGCA components are identified and extracted, various tasks can be applied in the data analysis process, like data visualization, clustering, denoising or classification. A numerical study demonstrates the usefulness of our method.

The network topology of neurons in the brain exhibits an abundance of feedback connections, but the computational function of these feedback connections is largely unknown. We present a computational theory that characterizes the gain in computational power achieved through feedback in dynamical systems with fading memory. It implies that many such systems acquire through feedback universal computational capabilities for analog computing with a non-fading memory. In particular, we show that feedback enables such systems to process time-varying input streams in diverse ways according to rules that are implemented through internal states of the dynamical system. In contrast to previous attractor-based computational models for neural networks, these flexible internal states are high-dimensional attractors of the circuit dynamics, that still allow the circuit state to absorb new information from online input streams. In this way one arrives at novel models for working memory, integration of evidence, and reward expectation in cortical circuits. We show that they are applicable to circuits of conductance-based Hodgkin-Huxley (HH) neurons with high levels of noise that reflect experimental data on invivo conditions.

We determine the asymptotic limit of the function computed by support vector machines (SVM) and related algorithms that minimize a regularized empiricalconvex loss function in the reproducing kernel Hilbert space of the Gaussian RBF kernel, in the situation where the number of examples tends to infinity, the bandwidth of the Gaussian kernel tends to 0, and the regularization parameter is held fixed.

We considered a gamma distribution of interspike intervals as a statistical modelfor neuronal spike generation. The model parameters consist of a time-dependent firing rate and a shape parameter that characterizes spiking irregularities of individual neurons. Because the environment changes with time, observed data are generated from the time-dependent firing rate, which is an unknown function. A statistical model with an unknown function is called a semiparametric model, which is one of the unsolved problem in statistics and is generally very difficult to solve. We used a novel method of estimating functions in information geometry to estimate the shape parameter without estimating the unknown function. We analytically obtained an optimal estimating function for the shape parameter independent of the functional form of the firing rate. This estimation is efficient without Fisher information loss and better than maximum likelihood estimation.

While classical kernel-based learning algorithms are based on a single kernel, in practice it is often desirable to use multiple kernels. Lankriet et al. (2004) considered conic combinations of kernel matrices for classification, leadingto a convex quadratically constraint quadratic program. We show that it can be rewritten as a semi-infinite linear program that can be efficiently solved by recycling the standard SVM implementations. Moreover,we generalize the formulation and our method to a larger class of problems, including regression and one-class classification. Experimentalresults show that the proposed algorithm helps for automatic model selection, improving the interpretability of the learning resultand works for hundred thousands of examples or hundreds of kernels to be combined.