Blind source separation, i.e. the extraction of unknown sources from a set of given signals, is relevant for many applications. A special case of this problem is dimension reduction, where the goal is to approximate a given set of signals by superpositions of a minimal number of sources. Since in this case the signals outnumber the sources the problem is over-determined. Most popular approaches for addressing this problem are based on purely linear mixing models. However, many applications like the modeling of acoustic signals, EMG signals, or movement trajectories, require temporal shift-invariance of the extracted components. This case has only rarely been treated in the computational literature, and specifically for the case of dimension reduction almost no algorithms have been proposed. We present a new algorithm for the solution of this problem, which is based on a timefrequency transformation (Wigner-Ville distribution) of the generative model. We show that this algorithm outperforms classical source separation algorithms for linear mixtures, and also a related method for mixtures with delays. In addition, applying the new algorithm to trajectories of human gaits, we demonstrate that it is suitable for the extraction of spatiotemporal components that are easier to interpret than components extracted with other classical algorithms.

This work presents a method for estimating human facial attractiveness, based on supervised learning techniques. Numerous facial features that describe facial geometry, color and texture, combined with an average human attractiveness score for each facial image, are used to train various predictors. Facial attractiveness ratings produced by the final predictor are found to be highly correlated with human ratings, markedly improving previous machine learning achievements. Simulated psychophysical experiments with virtually manipulated images reveal preferences in the machine's judgments which are remarkably similar to those of humans. These experiments shed new light on existing theories of facial attractiveness such as the averageness, smoothness and symmetry hypotheses. It is intriguing to find that a machine trained explicitly to capture an operational performance criteria such as attractiveness rating, implicitly captures basic human psychophysical biases characterizing the perception of facial attractiveness in general.

In previous studies, quadratic modelling of natural images has resulted in cell models that react strongly to edges and bars. Here we apply quadratic Independent Component Analysis to natural image patches, and show that up to a small approximation error, the estimated components are computing conjunctions of two linear features. These conjunctive features appear to represent not only edges and bars, but also inherently two-dimensional stimuli, such as corners. In addition, we show that for many of the components, the underlying linear features have essentially V1 simple cell receptive field characteristics. Our results indicate that the development of the V2 cells preferring angles and corners may be partly explainable by the principle of unsupervised sparse coding of natural images.

We propose a novel framework for the classification of single trial ElectroEncephaloGraphy (EEG), based on regularized logistic regression. Framed in this robust statistical framework no prior feature extraction or outlier removal is required.

Up to now even subjects that are experts in the use of machine learning based BCI systems still have to undergo a calibration session of about 20-30 min. From this data their (movement) intentions are so far infered. We now propose a new paradigm that allows to completely omit such calibration and instead transfer knowledge from prior sessions. To achieve this goal we first define normalized CSP features and distances in-between. Second, we derive prototypical features across sessions: (a) by clustering or (b) by feature concatenation methods. Finally, we construct a classifier based on these individualized prototypes and show that, indeed, classifiers can be successfully transferred to a new session for a number of subjects.

Starting with the work of Jaakkola and Haussler, a variety of approaches have been proposed for coupling domain-specific generative models with statistical learning methods. The link is established by a kernel function which provides a similarity measure based inherently on the underlying model. In computational biology, the full promise of this framework has rarely ever been exploited, as most kernels are derived from very generic models, such as sequence profiles or hidden Markov models. Here, we introduce the MTreeMix kernel, which is based on a generative model tailored to the underlying biological mechanism.

Many neural areas, notably, the hippocampus, show structured, dynamical, population behavior such as coordinated oscillations. It has long been observed that such oscillations provide a substrate for representing analog information in the firing phases of neurons relative to the underlying population rhythm. However, it has become increasingly clear that it is essential for neural populations to represent uncertainty about the information they capture, and the substantial recent work on neural codes for uncertainty has omitted any analysis of oscillatory systems. Here, we observe that, since neurons in an oscillatory network need not only fire once in each cycle (or even at all), uncertainty about the analog quantities each neuron represents by its firing phase might naturally be reported through the degree of concentration of the spikes that it fires. We apply this theory to memory in a model of oscillatory associative recall in hippocampal area CA3. Although it is not well treated in the literature, representing and manipulating uncertainty is fundamental to competent memory; our theory enables us to view CA3 as an effective uncertainty-aware, retrieval system.

The performance of EEGbased Brain-Computer-Interfaces (BCIs) critically depends on the extraction of features from the EEG carrying information relevant for the classification of different mental states. For BCIs employing imaginary movements of different limbs, the method of Common Spatial Patterns (CSP) has been shown to achieve excellent classification results. The CSP-algorithm however suffers from a lack of robustness, requiring training data without artifacts for good performance. To overcome this lack of robustness, we propose an adaptive spatial filter that replaces the training data in the CSP approach by a-priori information. More specifically, we design an adaptive spatial filter that maximizes the ratio of the variance of the electric field originating in a predefined region of interest (ROI) and the overall variance of the measured EEG. Since it is known that the component of the EEG used for discriminating imaginary movements originates in the motor cortex, we design two adaptive spatial filters with the ROIs centered in the hand areas of the left and right motor cortex. We then use these to classify EEG data recorded during imaginary movements of the right and left hand of three subjects, and show that the adaptive spatial filters outperform the CSP-algorithm, enabling classification rates of up to 94.7 % without artifact rejection.

We consider the problem of constructing a function whose zero set is to represent a surface, given sample points with surface normal vectors. The contributions include a novel means of regularising multi-scale compactly supported basis functions that leads to the desirable properties previously only associated with fully supported bases, and show equivalence to a Gaussian process with modified covariance function. We also provide a regularisation framework for simpler and more direct treatment of surface normals, along with a corresponding generalisation of the representer theorem. We demonstrate the techniques on 3D problems of up to 14 million data points, as well as 4D time series data.

We describe Hidden Semi-Markov Support Vector Machines (SHM SVMs), an extension of HM SVMs to semi-Markov chains. This allows us to predict segmentations of sequences based on segment-based features measuring properties such as the length of the segment. We propose a novel technique to partition the problem into sub-problems. The independently obtained partial solutions can then be recombined in an efficient way, which allows us to solve label sequence learning problems with several thousands of labeled sequences. We have tested our algorithm for predicting gene structures, an important problem in computational biology. Results on a well-known model organism illustrate the great potential of SHM SVMs in computational biology.