Martingales are indispensable in studying the temporal dynamics of stochastic processes arising in a multitude of fields [10, 14]. Particularly when such processes have complex long-range dependences, it is often of interest to concentrate martingales uniformly over time. On the theoretical side, a fundamental limit to such concentration is expressed by the law of the iterated logarithm (LIL). However, this only concerns asymptotic behavior. In many applications, it is more natural to instead consider concentration that holds uniformly over all finite times. This manuscript presents such bounds for the large classes of martingales which are addressed by Hoeffding [11] and Bernstein [8] inequalities. These new results are optimal within small constants, and can be viewed as finite-time generalizations of the upper half of the LIL.

The understanding of the type of inhibitory interaction plays an important role in drug design. Therefore, researchers are interested to know whether a drug has competitive or non-competitive interaction to particular protein targets. Method: to analyze the interaction types we propose factorization method Macau which allows us to combine different measurement types into a single tensor together with proteins and compounds. The compounds are characterized by high dimensional 2D ECFP fingerprints. The novelty of the proposed method is that using a specially designed noise injection MCMC sampler it can incorporate high dimensional side information, i.e., millions of unique 2D ECFP compound features, even for large scale datasets of millions of compounds. Without the side information, in this case, the tensor factorization would be practically futile. Results: using public IC50 and Ki data from ChEMBL we trained a model from where we can identify the latent subspace separating the two measurement types (IC50 and Ki). The results suggest the proposed method can detect the competitive inhibitory activity between compounds and proteins.

This paper proposes a distributionally robust approach to logistic regression. We use the Wasserstein distance to construct a ball in the space of probability distributions centered at the uniform distribution on the training samples. If the radius of this ball is chosen judiciously, we can guarantee that it contains the unknown data-generating distribution with high confidence. We then formulate a distributionally robust logistic regression model that minimizes a worst-case expected logloss function, where the worst case is taken over all distributions in the Wasserstein ball. We prove that this optimization problem admits a tractable reformulation and encapsulates the classical as well as the popular regularized logistic regression problems as special cases. We further propose a distributionally robust approach based on Wasserstein balls to compute upper and lower confidence bounds on the misclassification probability of the resulting classifier. These bounds are given by the optimal values of two highly tractable linear programs. We validate our theoretical out-of-sample guarantees through simulated and empirical experiments.

The Support Vector Machine (SVM) has been used in a wide variety of classification problems. The original SVM uses the hinge loss function, which is non-differentiable and makes the problem difficult to solve in particular for regularized SVMs, such as with $\ell_1$-regularization. This paper considers the Huberized SVM (HSVM), which uses a differentiable approximation of the hinge loss function. We first explore the use of the Proximal Gradient (PG) method to solving binary-class HSVM (B-HSVM) and then generalize it to multi-class HSVM (M-HSVM). Under strong convexity assumptions, we show that our algorithm converges linearly. In addition, we give a finite convergence result about the support of the solution, based on which we further accelerate the algorithm by a two-stage method. We present extensive numerical experiments on both synthetic and real datasets which demonstrate the superiority of our methods over some state-of-the-art methods for both binary- and multi-class SVMs.

Analysis of non-asymptotic estimation error and structured statistical recovery based on norm regularized regression, such as Lasso, needs to consider four aspects: the norm, the loss function, the design matrix, and the noise model. This paper presents generalizations of such estimation error analysis on all four aspects compared to the existing literature. We characterize the restricted error set where the estimation error vector lies, establish relations between error sets for the constrained and regularized problems, and present an estimation error bound applicable to any norm. Precise characterizations of the bound is presented for isotropic as well as anisotropic subGaussian design matrices, subGaussian noise models, and convex loss functions, including least squares and generalized linear models. Generic chaining and associated results play an important role in the analysis. A key result from the analysis is that the sample complexity of all such estimators depends on the Gaussian width of a spherical cap corresponding to the restricted error set. Further, once the number of samples $n$ crosses the required sample complexity, the estimation error decreases as $\frac{c}{\sqrt{n}}$, where $c$ depends on the Gaussian width of the unit norm ball.

Most ethical work is done at a low level of formality. This makes practical moral questions inaccessible to formal and natural sciences and can lead to misunderstandings in ethical discussion. In this paper, we use Bayesian inference to introduce a formalization of preference utilitarianism in physical world models, specifically cellular automata. Even though our formalization is not immediately applicable, it is a first step in providing ethics and ultimately the question of how to "make the world better" with a formal basis.

Automated sentiment analysis and opinion mining is a complex process concerning the extraction of useful subjective information from text. The explosion of user generated content on the Web, especially the fact that millions of users, on a daily basis, express their opinions on products and services to blogs, wikis, social networks, message boards, etc., render the reliable, automated export of sentiments and opinions from unstructured text crucial for several commercial applications. In this paper, we present a novel hybrid vectorization approach for textual resources that combines a weighted variant of the popular Word2Vec representation (based on Term Frequency-Inverse Document Frequency) representation and with a Bag- of-Words representation and a vector of lexicon-based sentiment values. The proposed text representation approach is assessed through the application of several machine learning classification algorithms on a dataset that is used extensively in literature for sentiment detection. The classification accuracy derived through the proposed hybrid vectorization approach is higher than when its individual components are used for text represenation, and comparable with state-of-the-art sentiment detection methodologies.

In this paper, we present a board game: Square War. The game definition of Square War is similar to the classic Chinese board game Go. Then we propose a mathematical problem of the game Square War. Finally, we show that the problem can be solved by using a method of mixed mathematics and computer science.

The $k$-nearest neighbour ($k$-NN) classifier is one of the oldest and most important supervised learning algorithms for classifying datasets. Traditionally the Euclidean norm is used as the distance for the $k$-NN classifier. In this thesis we investigate the use of alternative distances for the $k$-NN classifier. We start by introducing some background notions in statistical machine learning. We define the $k$-NN classifier and discuss Stone's theorem and the proof that $k$-NN is universally consistent on the normed space $R^d$. We then prove that $k$-NN is universally consistent if we take a sequence of random norms (that are independent of the sample and the query) from a family of norms that satisfies a particular boundedness condition. We extend this result by replacing norms with distances based on uniformly locally Lipschitz functions that satisfy certain conditions. We discuss the limitations of Stone's lemma and Stone's theorem, particularly with respect to quasinorms and adaptively choosing a distance for $k$-NN based on the labelled sample. We show the universal consistency of a two stage $k$-NN type classifier where we select the distance adaptively based on a split labelled sample and the query. We conclude by giving some examples of improvements of the accuracy of classifying various datasets using the above techniques.

We demonstrate that, in the classical non-stochastic regret minimization problem with $d$ decisions, gains and losses to be respectively maximized or minimized are fundamentally different. Indeed, by considering the additional sparsity assumption (at each stage, at most $s$ decisions incur a nonzero outcome), we derive optimal regret bounds of different orders. Specifically, with gains, we obtain an optimal regret guarantee after $T$ stages of order $\sqrt{T\log s}$, so the classical dependency in the dimension is replaced by the sparsity size. With losses, we provide matching upper and lower bounds of order $\sqrt{Ts\log(d)/d}$, which is decreasing in $d$. Eventually, we also study the bandit setting, and obtain an upper bound of order $\sqrt{Ts\log (d/s)}$ when outcomes are losses. This bound is proven to be optimal up to the logarithmic factor $\sqrt{\log(d/s)}$.