Existing automatic music generation approaches that feature deep learning can be broadly classified into two types: raw audio models and symbolic models. Symbolic models, which train and generate at the note level, are currently the more prevalent approach; these models can capture long-range dependencies of melodic structure, but fail to grasp the nuances and richness of raw audio generations. Raw audio models, such as DeepMind's WaveNet, train directly on sampled audio waveforms, allowing them to produce realistic-sounding, albeit unstructured music. In this paper, we propose an automatic music generation methodology combining both of these approaches to create structured, realistic-sounding compositions. We consider a Long Short Term Memory network to learn the melodic structure of different styles of music, and then use the unique symbolic generations from this model as a conditioning input to a WaveNet-based raw audio generator, creating a model for automatic, novel music. We then evaluate this approach by showcasing results of this work.

This paper addresses the problem of multi-agent inverse reinforcement learning (MIRL) in a two-player general-sum stochastic game framework. Five variants of MIRL are considered: uCS-MIRL, advE-MIRL, cooE-MIRL, uCE-MIRL, and uNE-MIRL, each distinguished by its solution concept. Problem uCS-MIRL is a cooperative game in which the agents employ cooperative strategies that aim to maximize the total game value. In problem uCE-MIRL, agents are assumed to follow strategies that constitute a correlated equilibrium while maximizing total game value. Problem uNE-MIRL is similar to uCE-MIRL in total game value maximization, but it is assumed that the agents are playing a Nash equilibrium. Problems advE-MIRL and cooE-MIRL assume agents are playing an adversarial equilibrium and a coordination equilibrium, respectively. We propose novel approaches to address these five problems under the assumption that the game observer either knows or is able to accurate estimate the policies and solution concepts for players. For uCS-MIRL, we first develop a characteristic set of solutions ensuring that the observed bi-policy is a uCS and then apply a Bayesian inverse learning method. For uCE-MIRL, we develop a linear programming problem subject to constraints that define necessary and sufficient conditions for the observed policies to be correlated equilibria. The objective is to choose a solution that not only minimizes the total game value difference between the observed bi-policy and a local uCS, but also maximizes the scale of the solution. We apply a similar treatment to the problem of uNE-MIRL. The remaining two problems can be solved efficiently by taking advantage of solution uniqueness and setting up a convex optimization problem. Results are validated on various benchmark grid-world games.

Mining relationships between treatment(s) and medical problem(s) is vital in the biomedical domain. This helps in various applications, such as decision support system, safety surveillance, and new treatment discovery. We propose a deep learning approach that utilizes both word level and sentence-level representations to extract the relationships between treatment and problem. While deep learning techniques demand a large amount of data for training, we make use of a rule-based system particularly for relationship classes with fewer samples. Our final relations are derived by jointly combining the results from deep learning and rule-based models. Our system achieved a promising performance on the relationship classes of I2b2 2010 relation extraction task.

The most widely used activation functions in current deep feed-forward neural networks are rectified linear units (ReLU), and many alternatives have been successfully applied, as well. However, none of the alternatives have managed to consistently outperform the rest and there is no unified theory connecting properties of the task and network with properties of activation functions for most efficient training. A possible solution is to have the network learn its preferred activation functions. In this work, we introduce Adaptive Blending Units (ABUs), a trainable linear combination of a set of activation functions. Since ABUs learn the shape, as well as the overall scaling of the activation function, we also analyze the effects of adaptive scaling in common activation functions. We experimentally demonstrate advantages of both adaptive scaling and ABUs over common activation functions across a set of systematically varied network specifications. We further show that adaptive scaling works by mitigating covariate shifts during training, and that the observed advantages in performance of ABUs likewise rely largely on the activation function's ability to adapt over the course of training.

Budgeted Stochastic Gradient Descent (BSGD) is a state-of-the-art technique for training large-scale kernelized support vector machines. The budget constraint is maintained incrementally by merging two points whenever the pre-defined budget is exceeded. The process of finding suitable merge partners is costly; it can account for up to 45% of the total training time. In this paper we investigate computationally more efficient schemes that merge more than two points at once. We obtain significant speed-ups without sacrificing accuracy.

Although timely sepsis diagnosis and prompt interventions in Intensive Care Unit (ICU) patients are associated with reduced mortality, early clinical recognition is frequently impeded by nonspecific signs of infection and failure to detect signs of sepsis-induced organ dysfunction in a constellation of dynamically changing physiological data. The goal of this work is to identify patient at risk of life-threatening sepsis utilizing a data-centered and machine learning-driven approach. We derive a mortality risk predictive dynamic Bayesian network (DBN) guided by a customized sepsis knowledgebase and compare the predictive accuracy of the derived DBN with the Sepsis-related Organ Failure Assessment (SOFA) score, the Quick SOFA (qSOFA) score, the Simplified Acute Physiological Score (SAPS-II) and the Modified Early Warning Score (MEWS) tools. A customized sepsis ontology was used to derive the DBN node structure and semantically characterize temporal features derived from both structured physiological data and unstructured clinical notes. We assessed the performance in predicting mortality risk of the DBN predictive model and compared performance to other models using Receiver Operating Characteristic (ROC) curves, area under curve (AUROC), calibration curves, and risk distributions. The derived dataset consists of 24,506 ICU stays from 19,623 patients with evidence of suspected infection, with 2,829 patients deceased at discharge. The DBN AUROC was found to be 0.91, which outperformed the SOFA (0.843), qSOFA (0.66), MEWS (0.729), and SAPS-II (0.766) scoring tools. Continuous Net Reclassification Index and Integrated Discrimination Improvement analysis supported the superiority DBN with respect to SOFA, qSOFA, MEWS, and SAPS-II. Compared with conventional rule-based risk scoring tools, the sepsis knowledgebase-driven DBN algorithm offers improved performance for predicting mortality of infected patients in intensive care units.

Support Vector Machines (SVMs) introduced by [5] are popular machine learning methods, in particular for binary classification. They are supported by learning-theoretical guarantees [14], and they exhibit excellent generalization performance in many applications in science and technology [1, 16, 29, 23, 22, 3, 18, 19, 10]. They belong to the family of kernel methods, applying a linear algorithm in a feature space defined implicitly by a kernel function. Training an SVM corresponds to solving a large-scale optimization problem, which can be cast into a quadratic program (QP). The primal problem can be solved directly with stochastic gradient descent (SGD) and accelerated variants [21, 8], while the dual QP is solved with subspace ascent, see [2] and references therein.

Limiting the model size of a kernel support vector machine to a pre-defined budget is a well-established technique that allows to scale SVM learning and prediction to large-scale data. Its core addition to simple stochastic gradient training is budget maintenance through merging of support vectors. This requires solving an inner optimization problem with an iterative method many times per gradient step. In this paper we replace the iterative procedure with a fast lookup. We manage to reduce the merging time by up to 65% and the total training time by 44% without any loss of accuracy.

Interpretable deep learning is a fundamental building block towards safer AI, especially when the deployment possibilities of deep learning-based computer-aided medical diagnostic systems are so eminent. However, without a computational formulation of black-box interpretation, general interpretability research rely heavily on subjective bias. Clear decision structure of the medical diagnostics lets us approximate the decision process of a radiologist as a model - removed from subjective bias. We define the process of interpretation as a finite communication between a known model and a black-box model to optimally map the black box's decision process in the known model. Consequently, we define interpretability as maximal information gain over the initial uncertainty about the black-box's decision within finite communication. We relax this definition based on the observation that diagnostic interpretation is typically achieved by a process of minimal querying. We derive an algorithm to calculate diagnostic interpretability. The usual question of accuracy-interpretability tradeoff, i.e. whether a black-box model's prediction accuracy is dependent on its ability to be interpreted by a known source model, does not arise in this theory. With multiple example simulation experiments of various complexity levels, we demonstrate the working of such a theoretical model in synthetic supervised classification scenarios.

It is widely believed that the backpropagation algorithm is essential for learning good feature detectors in early layers of artificial neural networks, so that these detectors are useful for the task performed by the higher layers of that neural network. At the same time, the traditional form of backpropagation is biologically implausible. In the present paper we propose an unusual learning rule, which has a degree of biological plausibility, and which is motivated by Hebb's idea that change of the synapse strength should be local - i.e. should depend only on the activities of the pre and post synaptic neurons. We design a learning algorithm that utilizes global inhibition in the hidden layer, and is capable of learning early feature detectors in a completely unsupervised way. These learned lower layer feature detectors can be used to train higher layer weights in a usual supervised way so that the performance of the full network is comparable to the performance of standard feedforward networks trained end-to-end with a backpropagation algorithm.