The online dating app profile picture has become something of an art form, with everything from carefully lit shots to hugging tigers becoming commonplace. However, researchers have now revealed that men might be wasting their time. Experts from the University of Oxford Internet Institute commissioned by dating site eHarmony found that in fact, looking average could be the better option. Experts from the University of Oxford Internet Institute commissioned by dating site eHarmony found that in fact, looking average could be the better option for men. Researchers analysed ten years of data from the site, and found men who rate their looks as five or six out of 10 receive more messages than men who give themselves a 10 out of 10 rating.

The clinical management of several cardiovascular conditions, such as pulmonary hypertension, require the assessment of the right ventricular (RV) function. This work addresses the fully automatic and robust access to one of the key RV biomarkers, its ejection fraction, from the gold standard imaging modality, MRI. The problem becomes the accurate segmentation of the RV blood pool from cine MRI sequences. This work proposes a solution based on Fully Convolutional Neural Networks (FCNN), where our first contribution is the optimal combination of three concepts (the convolution Gated Recurrent Units (GRU), the Generative Adversarial Networks (GAN), and the L1 loss function) that achieves an improvement of 0.05 and 3.49 mm in Dice Index and Hausdorff Distance respectively with respect to the baseline FCNN. This improvement is then doubled by our second contribution, the ROI-GAN, that sets two GANs to cooperate working at two fields of view of the image, its full resolution and the region of interest (ROI). Our rationale here is to better guide the FCNN learning by combining global (full resolution) and local Region Of Interest (ROI) features. The study is conducted in a large in-house dataset of $\sim$ 23.000 segmented MRI slices, and its generality is verified in a publicly available dataset.

Advanced video classification systems decode video frames to derive the necessary texture and motion representations for ingestion and analysis by spatio-temporal deep convolutional neural networks (CNNs). However, when considering visual Internet-of-Things applications, surveillance systems and semantic crawlers of large video repositories, the video capture and the CNN-based semantic analysis parts do not tend to be co-located. This necessitates the transport of compressed video over networks and incurs significant overhead in bandwidth and energy consumption, thereby significantly undermining the deployment potential of such systems. In this paper, we investigate the trade-off between the encoding bitrate and the achievable accuracy of CNN-based video classification models that directly ingest AVC/H.264 and HEVC encoded videos. Instead of retaining entire compressed video bitstreams and applying complex optical flow calculations prior to CNN processing, we only retain motion vector and select texture information at significantly-reduced bitrates and apply no additional processing prior to CNN ingestion. Based on three CNN architectures and two action recognition datasets, we achieve 11%-94% saving in bitrate with marginal effect on classification accuracy. A model-based selection between multiple CNNs increases these savings further, to the point where, if up to 7% loss of accuracy can be tolerated, video classification can take place with as little as 3 kbps for the transport of the required compressed video information to the system implementing the CNN models.

Online class imbalance learning constitutes a new problem and an emerging research topic that focusses on the challenges of online learning under class imbalance and concept drift. Class imbalance deals with data streams that have very skewed distributions while concept drift deals with changes in the class imbalance status. Little work exists that addresses these challenges and in this paper we introduce queue-based resampling, a novel algorithm that successfully addresses the co-existence of class imbalance and concept drift. The central idea of the proposed resampling algorithm is to selectively include in the training set a subset of the examples that appeared in the past. Results on two popular benchmark datasets demonstrate the effectiveness of queue-based resampling over state-of-the-art methods in terms of learning speed and quality.

We present an operational component of a real-world patient triage system. Given a specific patient presentation, the system is able to assess the level of medical urgency and issue the most appropriate recommendation in terms of best point of care and time to treat. We use an attention-based convolutional neural network architecture trained on 600,000 doctor notes in German. We compare two approaches, one that uses the full text of the medical notes and one that uses only a selected list of medical entities extracted from the text. These approaches achieve 79% and 66% precision, respectively, but on a confidence threshold of 0.6, precision increases to 85% and 75%, respectively. In addition, a method to detect warning symptoms is implemented to render the classification task transparent from a medical perspective. The method is based on the learning of attention scores and a method of automatic validation using the same data.

The accuracy of probability distributions inferred using machine-learning algorithms heavily depends on data availability and quality. In practical applications it is therefore fundamental to investigate the robustness of a statistical model to misspecification of some of its underlying probabilities. In the context of graphical models, investigations of robustness fall under the notion of sensitivity analyses. These analyses consist in varying some of the model's probabilities or parameters and then assessing how far apart the original and the varied distributions are. However, for Gaussian graphical models, such variations usually make the original graph an incoherent representation of the model's conditional independence structure. Here we develop an approach to sensitivity analysis which guarantees the original graph remains valid after any probability variation and we quantify the effect of such variations using different measures. To achieve this we take advantage of algebraic techniques to both concisely represent conditional independence and to provide a straightforward way of checking the validity of such relationships. Our methods are demonstrated to be robust and comparable to standard ones, which break the conditional independence structure of the model, using an artificial example and a medical real-world application.

Revealing latent structure in data is an active field of research, having brought exciting new models such as variational autoencoders and generative adversarial networks, and is essential to push machine learning towards unsupervised knowledge discovery. However, a major challenge is the lack of suitable benchmarks for an objective and quantitative evaluation of learned representations. To address this issue we introduce Morpho-MNIST. We extend the popular MNIST dataset by adding a morphometric analysis enabling quantitative comparison of different models, identification of the roles of latent variables, and characterisation of sample diversity. We further propose a set of quantifiable perturbations to assess the performance of unsupervised and supervised methods on challenging tasks such as outlier detection and domain adaptation. A key factor for progress in machine learning has been the availability of well curated, easy-to-use, standardised and sufficiently large annotated datasets for benchmarking different algorithms and models. This has led to major advances in speech recognition, computer vision, and natural language processing. A commonality between these tasks is their natural formulation as supervised learning tasks, wherein performance can be measured in terms of accuracy on a test set. The general problem of representation learning (i.e. to reveal latent structure in data) is more difficult to assess due the lack of suitable benchmarks.

We propose a method to efficiently learn diverse strategies in reinforcement learning for query reformulation in the tasks of document retrieval and question answering. In the proposed framework an agent consists of multiple specialized sub-agents and a meta-agent that learns to aggregate the answers from sub-agents to produce a final answer. Sub-agents are trained on disjoint partitions of the training data, while the meta-agent is trained on the full training set. Our method makes learning faster, because it is highly parallelizable, and has better generalization performance than strong baselines, such as an ensemble of agents trained on the full data. We show that the improved performance is due to the increased diversity of reformulation strategies.

Classical models describe primary visual cortex (V1) as a filter bank of orientation-selective linear-nonlinear (LN) or energy models, but these models fail to predict neural responses to natural stimuli accurately. Recent work shows that models based on convolutional neural networks (CNNs) lead to much more accurate predictions, but it remains unclear which features are extracted by V1 neurons beyond orientation selectivity and phase invariance. Here we work towards systematically studying V1 computations by categorizing neurons into groups that perform similar computations. We present a framework to identify common features independent of individual neurons' orientation selectivity by using a rotation-equivariant convolutional neural network, which automatically extracts every feature at multiple different orientations. We fit this model to responses of a population of 6000 neurons to natural images recorded in mouse primary visual cortex using two-photon imaging. We show that our rotation-equivariant network not only outperforms a regular CNN with the same number of feature maps, but also reveals a number of common features shared by many V1 neurons, which deviate from the typical textbook idea of V1 as a bank of Gabor filters. Our findings are a first step towards a powerful new tool to study the nonlinear computations in V1.

This document is designed to be a first-year graduate-level introduction to probabilistic programming. It not only provides a thorough background for anyone wishing to use a probabilistic programming system, but also introduces the techniques needed to design and build these systems. It is aimed at people who have an undergraduate-level understanding of either or, ideally, both probabilistic machine learning and programming languages. We start with a discussion of model-based reasoning and explain why conditioning as a foundational computation is central to the fields of probabilistic machine learning and artificial intelligence. We then introduce a simple first-order probabilistic programming language (PPL) whose programs define static-computation-graph, finite-variable-cardinality models. In the context of this restricted PPL we introduce fundamental inference algorithms and describe how they can be implemented in the context of models denoted by probabilistic programs. In the second part of this document, we introduce a higher-order probabilistic programming language, with a functionality analogous to that of established programming languages. This affords the opportunity to define models with dynamic computation graphs, at the cost of requiring inference methods that generate samples by repeatedly executing the program. Foundational inference algorithms for this kind of probabilistic programming language are explained in the context of an interface between program executions and an inference controller. This document closes with a chapter on advanced topics which we believe to be, at the time of writing, interesting directions for probabilistic programming research; directions that point towards a tight integration with deep neural network research and the development of systems for next-generation artificial intelligence applications.