Europe
A Human-in-the-Loop Bayesian Optimization Framework for Constraint-Aware Bioprocess Development
Stricker, Samuel, Wirnsperger, Claus, Butté, Alessandro, Helleckes, Laura, Gosálbez, Gonzalo Guillén, Chanona, Antonio del Rio, Mercangöz, Mehmet
This work presents an extension to Pareto Front Guided Sampling (PFGS), a Human-in-the-Loop (HitL) Bayesian Optimization (BO) framework in which Gaussian process (GP) surrogate-derived quantities are reformulated as objectives of a multi-objective optimization problem, and the resulting Pareto front is exposed to a domain expert for interactive candidate selection rather than returning a single automated recommendation. The framework is extended in two directions: constrained optimization is addressed by incorporating the posterior probability of satisfying output specification limits as an explicit Pareto objective, computed analytically from the GP posterior distribution; robust optimization is addressed by a Monte Carlo sampling strategy that estimates expected lower-confidence performance over a user-defined variability of input perturbations, capturing performance degradation under likely implementation deviations. The resulting multi-dimensional Pareto representation renders trade-offs between predicted performance, model uncertainty, probabilistic constraint satisfaction, and input robustness simultaneously visible through pairwise two-dimensional projections on an interactive dashboard, enabling selection criteria to be iteratively refined as the surrogate model improves and development objectives evolve. The framework is showcased on an eight-dimensional fed-batch Chinese Hamster Ovary (CHO) cell culture simulator demonstrating systematic identification of high-performing, feasibility-compliant, and perturbation-resilient operating conditions, and illustrating how expert-defined requirements provide a principled stopping criterion and support informed allocation of experimental resources.
Optimal score function estimation via derivatives constraints
Bonis, Thomas, Ngoc, Thanh Mai Pham, Tran, Viet Chi
We consider the problem of score function estimation via empirical risk minimization. We first start with the question of inferring the score function of a probability measure $μ$ with density on the flat torus from a sample of distribution $μ$. We show that constraining the hypothesis space to a Sobolev ball is sufficient to prevent overfitting and obtaining minimax estimation rates. We then consider the problem of score function estimation in the context of score-based generative modeling. Again, under a conjecture tying the score estimation rates to the quality of the output of a score-based generative model, we obtain minimax rates for such an approach using score function estimators obtained by constraining the hypothesis class to a Sobolev ball.
Improved Algorithms for Overlapping and Robust Clustering of Edge-Colored Hypergraphs: An LP-Based Combinatorial Approach
Clustering is a fundamental task in both machine learning and data mining. Among various methods, edge-colored clustering (ECC) has emerged as a useful approach for handling categorical data. Given a hypergraph with (hyper)edges labeled by colors, ECC aims to assign vertex colors to minimize the number of edges where the vertex color differs from the edge's color. However, traditional ECC has inherent limitations, as it enforces a nonoverlapping and exhaustive clustering. To tackle these limitations, three versions of ECC have been studied: LOCALECC and GLOBALECC, which allow overlapping clusters, and ROBUSTECC, which accounts for vertex outliers.
ChartSketcher Reasoning with Feedback and Reflection for Chart Understanding
Charts are high-density visualization carriers for complex data, serving as a crucial medium for information extraction and analysis. Automated chart understanding poses significant challenges to existing multimodal large language models (MLLMs) due to the need for precise and complex visual reasoning. Current step-by-step reasoning models primarily focus on text-based logical reasoning for chart understanding. However, they struggle to refine or correct their reasoning when errors stem from flawed visual understanding, as they lack the ability to leverage multimodal interaction for deeper comprehension. Inspired by human cognitive behavior, we propose ChartSketcher, a multimodal feedback-driven stepby-step reasoning method designed to address these limitations. ChartSketcher is a chart understanding model that employs Sketch-CoT, enabling MLLMs to annotate intermediate reasoning steps directly onto charts using a programmatic sketching library, iteratively feeding these visual annotations back into the reasoning process. This mechanism enables the model to visually ground its reasoning and refine its understanding over multiple steps. We employ a two-stage training strategy: a cold start phase to learn sketch-based reasoning patterns, followed by off-policy reinforcement learning to enhance reflection and generalization. Experiments demonstrate that ChartSketcher achieves promising performance on chart understanding benchmarks and general vision tasks, providing an interactive and interpretable approach to chart comprehension.
ChatGPT can be made to generate sexualised and violent images, researchers find
The latest public version of ChatGPT can be made to generate sexualised images or depict scenes of graphic violence with a simple prompt, researchers have told the BBC. British AI security startup Mindgard figured out how to make ChatGPT create graphic pictures by slightly altering a widely-shared instruction, or prompt, which was originally designed to produce humorous results. After being contacted by the BBC, ChatGPT's maker OpenAI said it had taken action to stop the chatbot responding with those types of images. After investigating this trend, we've introduced additional safeguards against this type of prompt, it said in a statement. It also said it has multiple layers of protection to prevent users making content which breaches its terms and conditions.
'We had to get out of the way': The backlash over delivery robots
'We had to get out of the way': The backlash over delivery robots The first time Chicago resident John Roberts saw a delivery robot trundling down the sidewalk on his street he was impressed. I actually thought they were kind of neat - it felt futuristic, he says. But his attitude started to change when, soon after, he was out for a walk with his family. As another robot approached, they found themselves having to dodge it. To us it felt a little off - the fact that we were on the one strip reserved for walking, and we were having to get out of the way, says Roberts.
Stop the Nonconsensual Use of Nude Images in Research
In order to train, test, and evaluate nudity detection models, machine learning researchers typically rely on nude images scraped from the Internet. Our research finds that this content is collected and, in some cases, subsequently distributed by researchers without consent, leading to potential misuse and exacerbating harm against the subjects depicted. This position paper argues that the distribution of nonconsensually collected nude images by researchers perpetuates imagebased sexual abuse and that the machine learning community should stop the nonconsensual use of nude images in research. To characterize the scope and nature of this problem, we conducted a systematic review of papers published in computing venues that collect and use nude images. Our results paint a grim reality: norms around the usage of nude images are sparse, leading to a litany of problematic practices like distributing and publishing nude images with uncensored faces, and intentionally collecting and sharing abusive content. We conclude with a call-to-action for publishing venues and a vision for research in nudity detection that balances user agency with concrete research objectives.
Markov Persuasion Processes: Learning to Persuade From Scratch
In Bayesian persuasion, an informed sender strategically discloses information to a receiver so as to persuade them to undertake desirable actions. Recently, Markov persuasion processes (MPPs) have been introduced to capture sequential scenarios where a sender faces a stream of myopic receivers in a Markovian environment. The MPPs studied so far in the literature suffer from issues that prevent them from being fully operational in practice, e.g., they assume that the sender knows receivers' rewards. We fix such issues by addressing MPPs where the sender has no knowledge about the environment.
Fast Projection-Free Approach (without Optimization Oracle) for Optimization over Compact Convex Set
Projection-free first-order methods, e.g., the celebrated Frank-Wolfe (FW) algorithms, have emerged as powerful tools for optimization over simple convex sets such as polyhedra, because of their scalability, fast convergence, and iteration-wise feasibility without costly projections. However, extending these methods effectively to general compact convex sets remains challenging and largely open, as FW methods rely on expensive linear optimization oracles (LOO), while penalty-based methods often struggle with poor feasibility. We tackle this open challenge by presenting Hom-PGD, a novel projection-free method without expensive (optimization) oracles. Our method constructs a homeomorphism between the convex constraint set and a unit ball, transforming the original problem into an equivalent ball-constrained formulation, thus enabling efficient gradient-based optimization while preserving the original problem structure. We prove that Hom-PGD attains optimal convergence rates matching gradient descent with constant step-size to find an ϵ-approximate (stationary) solution: O(log(1/ϵ))for strongly convex objectives, O(ϵ 1) for convex objectives, and O(ϵ 2) for non-convex objectives. Meanwhile, Hom-PGD enjoys a low per-iteration complexity of O(n2), without expensive oracles like LOO or projection, where nis the input size. Our framework further extends to certain non-convex sets, broadening its applicability in practical optimization scenarios with complex constraints. Extensive numerical experiments demonstrate that Hom-PGD achieves comparable convergence rates to state-of-theart projection-free methods, while significantly reducing per-iteration runtime (up to 5 orders of magnitude faster) and thus the total problem-solving time.
Direct Alignment with Heterogeneous Preferences
Alignment with human preferences is commonly framed using a universal reward function, even though human preferences are inherently heterogeneous. We formalize this heterogeneity by introducing user types and examine the limits of the homogeneity assumption. We show that aligning to heterogeneous preferences with a single policy is best achieved using the average reward across user types. However, this requires additional information about annotators. We examine improvements under different information settings, focusing on direct alignment methods. We find that minimal information can yield first-order improvements, while full feedback from each user type leads to consistent learning of the optimal policy. Surprisingly, however, no sample-efficient consistent direct loss exists in this latter setting. These results reveal a fundamental tension between consistency and sample efficiency in direct policy alignment.