Binary classification tasks with imbalanced classes pose significant challenges in machine learning. Traditional classifiers often struggle to accurately capture the characteristics of the minority class, resulting in biased models with subpar predictive performance. In this paper, we introduce a novel approach to tackle this issue by leveraging Universum points to support the minority class within quadratic twin support vector machine models. Unlike traditional classifiers, our models utilize quadratic surfaces instead of hyperplanes for binary classification, providing greater flexibility in modeling complex decision boundaries. By incorporating Universum points, our approach enhances classification accuracy and generalization performance on imbalanced datasets. We generated four artificial datasets to demonstrate the flexibility of the proposed methods. Additionally, we validated the effectiveness of our approach through empirical evaluations on benchmark datasets, showing superior performance compared to conventional classifiers and existing methods for imbalanced classification.

XAI refers to the techniques and methods for building AI applications which assist end users to interpret output and predictions of AI models. Black box AI applications in high-stakes decision-making situations, such as medical domain have increased the demand for transparency and explainability since wrong predictions may have severe consequences. Model explainability and interpretability are vital successful deployment of AI models in healthcare practices. AI applications' underlying reasoning needs to be transparent to clinicians in order to gain their trust. This paper presents a systematic review of XAI aspects and challenges in the healthcare domain. The primary goals of this study are to review various XAI methods, their challenges, and related machine learning models in healthcare. The methods are discussed under six categories: Features-oriented methods, global methods, concept models, surrogate models, local pixel-based methods, and human-centric methods. Most importantly, the paper explores XAI role in healthcare problems to clarify its necessity in safety-critical applications. The paper intends to establish a comprehensive understanding of XAI-related applications in the healthcare field by reviewing the related experimental results. To facilitate future research for filling research gaps, the importance of XAI models from different viewpoints and their limitations are investigated.

In addition to being a widely recognised novelist, Milan Kundera has also authored three pieces for theatre: The Owners of the Keys (Majitel\'e kl\'i\v{c}\r{u}, 1961), The Blunder (Pt\'akovina, 1967), and Jacques and his Master (Jakub a jeho p\'an, 1971). In recent years, however, the hypothesis has been raised that Kundera is the true author of a fourth play: Juro J\'ano\v{s}\'ik, first performed in a 1974 production under the name of Karel Steigerwald, who was Kundera's student at the time. In this study, we make use of supervised machine learning to settle the question of authorship attribution in the case of Juro J\'ano\v{s}\'ik, with results strongly supporting the hypothesis of Kundera's authorship.