"Artificial intelligence, or AI, is rapidly transforming the world of medicine. AI computers are diagnosing medical conditions at a rate equal to or better than humans, all while developing their own code and algorithms to do so. With the rise of AI, there are new issues of patentability, inventorship, and ownership that must be addressed." "Recruiting and hiring is the most common use of advanced data analytics and artificial intelligence, adopted by 49 percent of survey respondents." Be developed for the common good.

The task of drug-target interaction prediction holds significant importance in pharmacology and therapeutic drug design. In this paper, we present FRnet-DTI, an auto encoder and a convolutional classifier for feature manipulation and drug target interaction prediction. Two convolutional neural neworks are proposed where one model is used for feature manipulation and the other one for classification. Using the first method FRnet-1, we generate 4096 features for each of the instances in each of the datasets and use the second method, FRnet-2, to identify interaction probability employing those features. We have tested our method on four gold standard datasets exhaustively used by other researchers. Experimental results shows that our method significantly improves over the state-of-the-art method on three of the four drug-target interaction gold standard datasets on both area under curve for Receiver Operating Characteristic(auROC) and area under Precision Recall curve(auPR) metric. We also introduce twenty new potential drug-target pairs for interaction based on high prediction scores. Codes Available: https: // github. com/ farshidrayhanuiu/ FRnet-DTI/ Web Implementation: http: // farshidrayhan. pythonanywhere. com/ FRnet-DTI/

The optimization of expensive-to-evaluate black-box functions over combinatorial structures is an ubiquitous task in machine learning, engineering and the natural sciences. The combinatorial explosion of the search space and costly evaluations pose challenges for current techniques in discrete optimization and machine learning, and critically require new algorithmic ideas (NIPS BayesOpt 2017). This article proposes, to the best of our knowledge, the first algorithm to overcome these challenges, based on an adaptive, scalable model that identifies useful combinatorial structure even when data is scarce. Our acquisition function pioneers the use of semidefinite programming to achieve efficiency and scalability. Experimental evaluations demonstrate that this algorithm consistently outperforms other methods from combinatorial and Bayesian optimization.

Acute respiratory infections have epidemic and pandemic potential and thus are being studied worldwide, albeit in many different contexts and study formats. Predicting infection from symptom data is critical, though using symptom data from varied studies in aggregate is challenging because the data is collected in different ways. Accordingly, different symptom profiles could be more predictive in certain studies, or even symptoms of the same name could have different meanings in different contexts. We assess state-of-the-art transfer learning methods for improving prediction of infection from symptom data in multiple types of health care data ranging from clinical, to home-visit as well as crowdsourced studies. We show interesting characteristics regarding six different study types and their feature domains. Further, we demonstrate that it is possible to use data collected from one study to predict infection in another, at close to or better than using a single dataset for prediction on itself. We also investigate in which conditions specific transfer learning and domain adaptation methods may perform better on symptom data. This work has the potential for broad applicability as we show how it is possible to transfer learning from one public health study design to another, and data collected from one study may be used for prediction of labels for another, even collected through different study designs, populations and contexts.

We propose two algorithms that can find local minima faster than the state-of-the-art algorithms in both finite-sum and general stochastic nonconvex optimization. At the core of the proposed algorithms is $\text{One-epoch-SNVRG}^+$ using stochastic nested variance reduction (Zhou et al., 2018a), which outperforms the state-of-the-art variance reduction algorithms such as SCSG (Lei et al., 2017). In particular, for finite-sum optimization problems, the proposed $\text{SNVRG}^{+}+\text{Neon2}^{\text{finite}}$ algorithm achieves $\tilde{O}(n^{1/2}\epsilon^{-2}+n\epsilon_H^{-3}+n^{3/4}\epsilon_H^{-7/2})$ gradient complexity to converge to an $(\epsilon, \epsilon_H)$-second-order stationary point, which outperforms $\text{SVRG}+\text{Neon2}^{\text{finite}}$ (Allen-Zhu and Li, 2017) , the best existing algorithm, in a wide regime. For general stochastic optimization problems, the proposed $\text{SNVRG}^{+}+\text{Neon2}^{\text{online}}$ achieves $\tilde{O}(\epsilon^{-3}+\epsilon_H^{-5}+\epsilon^{-2}\epsilon_H^{-3})$ gradient complexity, which is better than both $\text{SVRG}+\text{Neon2}^{\text{online}}$ (Allen-Zhu and Li, 2017) and Natasha2 (Allen-Zhu, 2017) in certain regimes. Furthermore, we explore the acceleration brought by third-order smoothness of the objective function.

Recurrent neural networks (RNNs) have been drawing much attention with great success in many applications like speech recognition and neural machine translation. Long short-term memory (LSTM) is one of the most popular RNN units in deep learning applications. LSTM transforms the input and the previous hidden states to the next states with the affine transformation, multiplication operations and a nonlinear activation function, which makes a good data representation for a given task. The affine transformation includes rotation and reflection, which change the semantic or syntactic information of dimensions in the hidden states. However, considering that a model interprets the output sequence of LSTM over the whole input sequence, the dimensions of the states need to keep the same type of semantic or syntactic information regardless of the location in the sequence. In this paper, we propose a simple variant of the LSTM unit, persistent recurrent unit (PRU), where each dimension of hidden states keeps persistent information across time, so that the space keeps the same meaning over the whole sequence. In addition, to improve the nonlinear transformation power, we add a feedforward layer in the PRU structure. In the experiment, we evaluate our proposed methods with three different tasks, and the results confirm that our methods have better performance than the conventional LSTM.

This two-part work puts forth the idea of engaging power electronics to probe an electric grid to infer non-metered loads. Probing can be accomplished by commanding inverters to perturb their power injections and record the induced voltage response. Once a probing setup is deemed topologically observable by the tests of Part I, Part II provides a methodology for designing probing injections abiding by inverter and network constraints to improve load estimates. The task is challenging since system estimates depend on both probing injections and unknown loads in an implicit nonlinear fashion. The methodology first constructs a library of candidate probing vectors by sampling over the feasible set of inverter injections. Leveraging a linearized grid model and a robust approach, the candidate probing vectors violating voltage constraints for any anticipated load value are subsequently rejected. Among the qualified candidates, the design finally identifies the probing vectors yielding the most diverse system states. The probing task under noisy phasor and non-phasor data is tackled using a semidefinite-program (SDP) relaxation. Numerical tests using synthetic and real-world data on a benchmark feeder validate the conditions of Part I; the SDP-based solver; the importance of probing design; and the effects of probing duration and noise.

Stability is a key aspect of data analysis. In many applications, the natural notion of stability is geometric, as illustrated for example in computer vision. Scattering transforms construct deep convolutional representations which are certified stable to input deformations. This stability to deformations can be interpreted as stability with respect to changes in the metric structure of the domain. In this work, we show that scattering transforms can be generalized to non-Euclidean domains using diffusion wavelets, while preserving a notion of stability with respect to metric changes in the domain, measured with diffusion maps. The resulting representation is stable to metric perturbations of the domain while being able to capture "high-frequency" information, akin to the Euclidean Scattering.

Armed conflict has led to an unprecedented number of internally displaced persons (IDPs) - individuals who are forced out of their homes but remain within their country. IDPs often urgently require shelter, food, and healthcare, yet prediction of when large fluxes of IDPs will cross into an area remains a major challenge for aid delivery organizations. Accurate forecasting of IDP migration would empower humanitarian aid groups to more effectively allocate resources during conflicts. We show that monthly flow of IDPs from province to province in both Syria and Yemen can be accurately forecasted one month in advance, using publicly available data. We model monthly IDP flow using data on food price, fuel price, wage, geospatial, and news data. We find that machine learning approaches can more accurately forecast migration trends than baseline persistence models. Our findings thus potentially enable proactive aid allocation for IDPs in anticipation of forecasted arrivals.

This paper attempts to provide a state of the art in trend prediction using news headlines. We present the research done on predicting DJIA trends using Natural Language Processing. We will explain the different algorithms we have used as well as the various embedding techniques attempted. We rely on statistical and deep learning models in order to extract information from the corpuses.