It is the efficient use of resources expected from an exam scheduling application. There are various criteria for efficient use of resources and for all tests to be carried out at minimum cost in the shortest possible time. It is aimed that educational institutions with such criteria successfully carry out central examination organizations. In the study, a two-stage genetic algorithm was developed. In the first stage, the assignment of courses to sessions was carried out. In the second stage, the students who participated in the test session were assigned to examination rooms. Purposes of the study are increasing the number of joint students participating in sessions, using the minimum number of buildings in the same session, and reducing the number of supervisors using the minimum number of classrooms possible. In this study, a general purpose exam scheduling solution for educational institutions was presented. The developed system can be used in different central examinations to create originality. Given the results of the sample application, it is seen that the proposed genetic algorithm gives successful results.1

Staff scheduling is a universal problem that can be encountered in many organizations, such as call centers, educational institution, industry, hospital, and any other public services. It is one of the most important aspects of workforce management strategy and the one that is most prone to errors or issues as there are many entities should be considered, such as the staff turnover, employee availability, time between rotations, unusual periods of activity, and even the last-minute shift changes. The nurse scheduling problem is a variant of staff scheduling problems which appoints nurses to shifts as well as rooms per day taking both hard constraints, i.e., hospital requirements, and soft constraints, i.e., nurse preferences, into account. Most algorithms used for scheduling problems fall short when it comes to the number of inputs they can handle. In this paper, constraint programming was developed to solve the nurse scheduling problem. The developed constraint programming model was then implemented using python programming language.

In this paper, we take a first step towards generalizing a recently proposed method for dealing with the problem of convergence to incorrect equilibrium points of distance-based formation controllers. Specifically, we introduce a distance and area-based scheme for the formation control of $n$-agent systems in two dimensions using directed graphs and the single-integrator model. We show that under certain conditions on the edge lengths of the triangulated desired formation, the control ensures almost-global convergence to the correct formation.

Digital Adherence Technologies (DATs) are an increasingly popular method for verifying patient adherence to many medications. We analyze data from one city served by 99DOTS, a phone-call-based DAT deployed for Tuberculosis (TB) treatment in India where nearly 3 million people are afflicted with the disease each year. The data contains nearly 17,000 patients and 2.1M phone calls. We lay the groundwork for learning from this real-world data, including a method for avoiding the effects of unobserved interventions in training data used for machine learning. We then construct a deep learning model, demonstrate its interpretability, and show how it can be adapted and trained in three different clinical scenarios to better target and improve patient care. In the real-time risk prediction setting our model could be used to proactively intervene with 21% more patients and before 76% more missed doses than current heuristic baselines. For outcome prediction, our model performs 40% better than baseline methods, allowing cities to target more resources to clinics with a heavier burden of patients at risk of failure. Finally, we present a case study demonstrating how our model can be trained in an end-to-end decision focused learning setting to achieve 15% better solution quality in an example decision problem faced by health workers.

The field of precision medicine aims to tailor treatment based on patient-specific factors in a reproducible way. To this end, estimating an optimal individualized treatment regime (ITR) that recommends treatment decisions based on patient characteristics to maximize the mean of a pre-specified outcome is of particular interest. Several methods have been proposed for estimating an optimal ITR from clinical trial data in the parallel group setting where each subject is randomized to a single intervention. However, little work has been done in the area of estimating the optimal ITR from crossover study designs. Such designs naturally lend themselves to precision medicine, because they allow for observing the response to multiple treatments for each patient. In this paper, we introduce a method for estimating the optimal ITR using data from a 2x2 crossover study with or without carryover effects. The proposed method is similar to policy search methods such as outcome weighted learning; however, we take advantage of the crossover design by using the difference in responses under each treatment as the observed reward. We establish Fisher and global consistency, present numerical experiments, and analyze data from a feeding trial to demonstrate the improved performance of the proposed method compared to standard methods for a parallel study design.

Motivation: Prediction of the interaction affinity between proteins and compounds is a major challenge in the drug discovery process. WideDTA is a deep-learning based prediction model that employs chemical and biological textual sequence information to predict binding affinity. Results: WideDTA uses four text-based information sources, namely the protein sequence, ligand SMILES, protein domains and motifs, and maximum common substructure words to predict binding affinity. WideDTA outperformed one of the state of the art deep learning methods for drug-target binding affinity prediction, DeepDTA on the KIBA dataset with a statistical significance. This indicates that the word-based sequence representation adapted by WideDTA is a promising alternative to the character-based sequence representation approach in deep learning models for binding affinity prediction, such as the one used in DeepDTA. In addition, the results showed that, given the protein sequence and ligand SMILES, the inclusion of protein domain and motif information as well as ligand maximum common substructure words do not provide additional useful information for the deep learning model. Interestingly, however, using only domain and motif information to represent proteins achieved similar performance to using the full protein sequence, suggesting that important binding relevant information is contained within the protein motifs and domains.

Energy disaggregation in a non-intrusive way estimates appliance level electricity consumption from a single meter that measures the whole house electricity demand. Recently, with the ongoing increment of energy data, there are many data-driven deep learning architectures being applied to solve the non-intrusive energy disaggregation problem. However, most proposed methods try to estimate the on-off state or the power consumption of appliance, which need not only large amount of parameters, but also hyper-parameter optimization prior to training and even preprocessing of energy data for a specified appliance. In this paper, instead of estimating on-off state or power consumption, we adapt a neural network to estimate the operational state change of appliance. Our proposed solution is more feasible across various appliances and lower complexity comparing to previous methods. The simulated experiments in the low sample rate dataset REDD show the competitive performance of the designed method, with respect to other two benchmark methods, Hidden Markov Model-based and Graph Signal processing-based approaches.

Attention is an increasingly popular mechanism used in a wide range of neural architectures. Because of the fast-paced advances in this domain, a systematic overview of attention is still missing. In this article, we define a unified model for attention architectures for natural language processing, with a focus on architectures designed to work with vector representation of the textual data. We discuss the dimensions along which proposals differ, the possible uses of attention, and chart the major research activities and open challenges in the area.

Voice activity detection (VAD), used as the front end of speech enhancement, speech and speaker recognition algorithms, determines the overall accuracy and efficiency of the algorithms. Therefore, a VAD with low complexity and high accuracy is highly desirable for speech processing applications. In this paper, we propose a novel training method on large dataset for supervised learning-based VAD system using support vector machine (SVM). Despite of high classification accuracy of support vector machines (SVM), trivial SVM is not suitable for classification of large data sets needed for a good VAD system because of high training complexity. To overcome this problem, a novel ensemble-based approach using SVM has been proposed in this paper.The performance of the proposed ensemble structure has been compared with a feedforward neural network (NN). Although NN performs better than single SVM-based VAD trained on a small portion of the training data, ensemble SVM gives accuracy comparable to neural network-based VAD. Ensemble SVM and NN give 88.74% and 86.28% accuracy respectively whereas the stand-alone SVM shows 57.05% accuracy on average on the test dataset.

Perturbative GAN, which replaces convolution layers of existing convolutional GANs (DCGAN, WGAN-GP, BIGGAN, etc.) with perturbation layers that adds a fixed noise mask, is proposed. Compared with the convolu-tional GANs, the number of parameters to be trained is smaller, the convergence of training is faster, the incep-tion score of generated images is higher, and the overall training cost is reduced. Algorithmic generation of the noise masks is also proposed, with which the training, as well as the generation, can be boosted with hardware acceleration. Perturbative GAN is evaluated using con-ventional datasets (CIFAR10, LSUN, ImageNet), both in the cases when a perturbation layer is adopted only for Generators and when it is introduced to both Generator and Discriminator.