Epidemic outbreaks can cause critical health concerns and severe global economic crises. For countries or regions with new infectious disease outbreaks, it is essential to generate preventive strategies by learning lessons from others with similar risk profiles. A Strategy Transfer and Decision Support Approach (STDSA) is proposed based on the profile similarity evaluation. There are four steps in this method: (1) The similarity evaluation indicators are determined from three dimensions, i.e., the Basis of National Epidemic Prevention & Control, Social Resilience, and Infection Situation. (2) The data related to the indicators are collected and preprocessed. (3) The first round of screening on the preprocessed dataset is conducted through an improved collaborative filtering algorithm to calculate the preliminary similarity result from the perspective of the infection situation. (4) Finally, the K-Means model is used for the second round of screening to obtain the final similarity values. The approach will be applied to decision-making support in the context of COVID-19. Our results demonstrate that the recommendations generated by the STDSA model are more accurate and aligned better with the actual situation than those produced by pure K-means models. This study will provide new insights into preventing and controlling epidemics in regions that lack experience.

As we make tremendous advances in machine learning and artificial intelligence technosciences, there is a renewed understanding in the AI community that we must ensure that humans being are at the center of our deliberations so that we don't end in technology-induced dystopias. As strongly argued by Green in his book Smart Enough City, the incorporation of technology in city environs does not automatically translate into prosperity, wellbeing, urban livability, or social justice. There is a great need to deliberate on the future of the cities worth living and designing. There are philosophical and ethical questions involved along with various challenges that relate to the security, safety, and interpretability of AI algorithms that will form the technological bedrock of future cities. Several research institutes on human centered AI have been established at top international universities. Globally there are calls for technology to be made more humane and human-compatible. For example, Stuart Russell has a book called Human Compatible AI. The Center for Humane Technology advocates for regulators and technology companies to avoid business models and product features that contribute to social problems such as extremism, polarization, misinformation, and Internet addiction. In this paper, we analyze and explore key challenges including security, robustness, interpretability, and ethical challenges to a successful deployment of AI or ML in human-centric applications, with a particular emphasis on the convergence of these challenges. We provide a detailed review of existing literature on these key challenges and analyze how one of these challenges may lead to others or help in solving other challenges. The paper also advises on the current limitations, pitfalls, and future directions of research in these domains, and how it can fill the current gaps and lead to better solutions.

Accurately determining a change in protein binding affinity upon mutations is important for the discovery and design of novel therapeutics and to assist mutagenesis studies. Determination of change in binding affinity upon mutations requires sophisticated, expensive, and time-consuming wet-lab experiments that can be aided with computational methods. Most of the computational prediction techniques require protein structures that limit their applicability to protein complexes with known structures. In this work, we explore the sequence-based prediction of change in protein binding affinity upon mutation. We have used protein sequence information instead of protein structures along with machine learning techniques to accurately predict the change in protein binding affinity upon mutation. Our proposed sequence-based novel change in protein binding affinity predictor called PANDA gives better accuracy than existing methods over the same validation set as well as on an external independent test dataset. On an external test dataset, our proposed method gives a maximum Pearson correlation coefficient of 0.52 in comparison to the state-of-the-art existing protein structure-based method called MutaBind which gives a maximum Pearson correlation coefficient of 0.59. Our proposed protein sequence-based method, to predict a change in binding affinity upon mutations, has wide applicability and comparable performance in comparison to existing protein structure-based methods.