This paper presents an improved forward-backward splitting algorithm with two inertial parameters. It aims to find a point in the real Hilbert space at which the sum of a co-coercive operator and a maximal monotone operator vanishes. Under standard assumptions, our proposed algorithm demonstrates weak convergence. We present numerous experimental results to demonstrate the behavior of the developed algorithm by comparing it with existing algorithms in the literature for regression and data classification problems. Furthermore, these implementations suggest our proposed algorithm yields superior outcomes when benchmarked against other relevant algorithms in existing literature.

Quantitative mass spectrometry has revolutionized proteomics by enabling simultaneous quantification of thousands of proteins. Pooling patient-derived data from multiple institutions enhances statistical power but raises significant privacy concerns. Here we introduce FedProt, the first privacy-preserving tool for collaborative differential protein abundance analysis of distributed data, which utilizes federated learning and additive secret sharing. In the absence of a multicenter patient-derived dataset for evaluation, we created two, one at five centers from LFQ E.coli experiments and one at three centers from TMT human serum. Evaluations using these datasets confirm that FedProt achieves accuracy equivalent to DEqMS applied to pooled data, with completely negligible absolute differences no greater than $\text{$4 \times 10^{-12}$}$. In contrast, -log10(p-values) computed by the most accurate meta-analysis methods diverged from the centralized analysis results by up to 25-27. FedProt is available as a web tool with detailed documentation as a FeatureCloud App.

Selective labels occur when label observations are subject to a decision-making process; e.g., diagnoses that depend on the administration of laboratory tests. We study a clinically-inspired selective label problem called disparate censorship, where labeling biases vary across subgroups and unlabeled individuals are imputed as "negative" (i.e., no diagnostic test = no illness). Machine learning models naively trained on such labels could amplify labeling bias. Inspired by causal models of selective labels, we propose Disparate Censorship Expectation-Maximization (DCEM), an algorithm for learning in the presence of disparate censorship. We theoretically analyze how DCEM mitigates the effects of disparate censorship on model performance. We validate DCEM on synthetic data, showing that it improves bias mitigation (area between ROC curves) without sacrificing discriminative performance (AUC) compared to baselines. We achieve similar results in a sepsis classification task using clinical data.

Traffic accidents pose a severe global public health issue, leading to 1.19 million fatalities annually, with the greatest impact on individuals aged 5 to 29 years old. This paper addresses the critical need for advanced predictive methods in road safety by conducting a comprehensive review of recent advancements in applying machine learning (ML) techniques to traffic accident analysis and prediction. It examines 191 studies from the last five years, focusing on predicting accident risk, frequency, severity, duration, as well as general statistical analysis of accident data. To our knowledge, this study is the first to provide such a comprehensive review, covering the state-of-the-art across a wide range of domains related to accident analysis and prediction. The review highlights the effectiveness of integrating diverse data sources and advanced ML techniques to improve prediction accuracy and handle the complexities of traffic data. By mapping the current landscape and identifying gaps in the literature, this study aims to guide future research towards significantly reducing traffic-related deaths and injuries by 2030, aligning with the World Health Organization (WHO) targets.

Kurdish libraries have many historical publications that were printed back in the early days when printing devices were brought to Kurdistan. Having a good Optical Character Recognition (OCR) to help process these publications and contribute to the Kurdish languages resources which is crucial as Kurdish is considered a low-resource language. Current OCR systems are unable to extract text from historical documents as they have many issues, including being damaged, very fragile, having many marks left on them, and often written in non-standard fonts and more. This is a massive obstacle in processing these documents as currently processing them requires manual typing which is very time-consuming. In this study, we adopt an open-source OCR framework by Google, Tesseract version 5.0, that has been used to extract text for various languages. Currently, there is no public dataset, and we developed our own by collecting historical documents from Zheen Center for Documentation and Research, which were printed before 1950 and resulted in a dataset of 1233 images of lines with transcription of each. Then we used the Arabic model as our base model and trained the model using the dataset. We used different methods to evaluate our model, Tesseracts built-in evaluator lstmeval indicated a Character Error Rate (CER) of 0.755%. Additionally, Ocreval demonstrated an average character accuracy of 84.02%. Finally, we developed a web application to provide an easy- to-use interface for end-users, allowing them to interact with the model by inputting an image of a page and extracting the text. Having an extensive dataset is crucial to develop OCR systems with reasonable accuracy, as currently, no public datasets are available for historical Kurdish documents; this posed a significant challenge in our work. Additionally, the unaligned spaces between characters and words proved another challenge with our work.

An arrhythmia, also known as a dysrhythmia, refers to an irregular heartbeat. There are various types of arrhythmias that can originate from different areas of the heart, resulting in either a rapid, slow, or irregular heartbeat. An electrocardiogram (ECG) is a vital diagnostic tool used to detect heart irregularities and abnormalities, allowing experts to analyze the heart's electrical signals to identify intricate patterns and deviations from the norm. Over the past few decades, numerous studies have been conducted to develop automated methods for classifying heartbeats based on ECG data. In recent years, deep learning has demonstrated exceptional capabilities in tackling various medical challenges, particularly with transformers as a model architecture for sequence processing. By leveraging the transformers, we developed the ECGformer model for the classification of various arrhythmias present in electrocardiogram data. We assessed the suggested approach using the MIT-BIH and PTB datasets. ECG heartbeat arrhythmia classification results show that the proposed method is highly effective.

Abstract-- Alzheimer's is a brain disease that gets worse over AD is a neurodegenerative disorder caused by abnormal protein deposits in the brain, causing nerve cells to degenerate The Transformer architecture, which dominates natural and eventually die. This leads to diminished cognitive language processing [8], has gained popularity in computer function, altered mood, and behavior [1], [2]. Alzheimer's vision due to its impressive results in tasks like image disease has no known cure, but treatments can manage classification, object detection, and semantic segmentation. Common symptoms include ViT, based on Transformers, has been applied to images with memory loss, difficulty with tasks, language difficulties, minimal modifications and has shown superior performance disorientation, poor judgment, abstract thought issues, object in many computer-vision tasks, making it a viable alternative misplacement, mood changes, and motivation loss. CNNs gradually collect Alzheimer's disease begins in the preclinical stage, where features from local to global using convolutional layers.

Discontinuities can be fairly arbitrary but also cause a significant impact on outcomes in larger systems. Indeed, their arbitrariness is why they have been used to infer causal relationships among variables in numerous settings. Regression discontinuity from econometrics assumes the existence of a discontinuous variable that splits the population into distinct partitions to estimate the causal effects of a given phenomenon. Here we consider the design of partitions for a given discontinuous variable to optimize a certain effect previously studied using regression discontinuity. To do so, we propose a quantization-theoretic approach to optimize the effect of interest, first learning the causal effect size of a given discontinuous variable and then applying dynamic programming for optimal quantization design of discontinuities to balance the gain and loss in that effect size. We also develop a computationally-efficient reinforcement learning algorithm for the dynamic programming formulation of optimal quantization. We demonstrate our approach by designing optimal time zone borders for counterfactuals of social capital, social mobility, and health. This is based on regression discontinuity analyses we perform on novel data, which may be of independent empirical interest.

Machine learning models are often trained to predict the outcome resulting from a human decision. For example, if a doctor decides to test a patient for disease, will the patient test positive? A challenge is that the human decision censors the outcome data: we only observe test outcomes for patients doctors historically tested. Untested patients, for whom outcomes are unobserved, may differ from tested patients along observed and unobserved dimensions. We propose a Bayesian model class which captures this setting. The purpose of the model is to accurately estimate risk for both tested and untested patients. Estimating this model is challenging due to the wide range of possibilities for untested patients. To address this, we propose two domain constraints which are plausible in health settings: a prevalence constraint, where the overall disease prevalence is known, and an expertise constraint, where the human decision-maker deviates from purely risk-based decision-making only along a constrained feature set. We show theoretically and on synthetic data that domain constraints improve parameter inference. We apply our model to a case study of cancer risk prediction, showing that the model's inferred risk predicts cancer diagnoses, its inferred testing policy captures known public health policies, and it can identify suboptimalities in test allocation. Though our case study is in healthcare, our analysis reveals a general class of domain constraints which can improve model estimation in many settings.

In the face of rapidly accumulating genomic data, our understanding of the RNA regulatory code remains incomplete. Recent self-supervised methods in other domains have demonstrated the ability to learn rules underlying the data-generating process such as sentence structure in language. Inspired by this, we extend contrastive learning techniques to genomic data by utilizing functional similarities between sequences generated through alternative splicing and gene duplication. Our novel dataset and contrastive objective enable the learning of generalized RNA isoform representations. We validate their utility on downstream tasks such as RNA half-life and mean ribosome load prediction. Our pre-training strategy yields competitive results using linear probing on both tasks, along with up to a two-fold increase in Pearson correlation in low-data conditions. Importantly, our exploration of the learned latent space reveals that our contrastive objective yields semantically meaningful representations, underscoring its potential as a valuable initialization technique for RNA property prediction. Mature RNAs are molecules that encode genetic information and are thoroughly regulated by the cell to control protein expression and other functions. Many aspects of this regulation are determined by the RNA sequence. Experimental procedures measuring these properties have been instrumental in understanding cellular function and disease impact. However, experiments are often high-cost and time-consuming. Supervised learning models trained on genetic sequences to predict cellular function provide effective, low-cost tools.