Given the ubiquity of modularity in biological systems, module-level regulation analysis is vital for understanding biological systems across various levels and their dynamics. Current statistical analysis on biological modules predominantly focuses on either detecting the functional modules in biological networks or sub-group regression on the biological features without using the network data. This paper proposes a novel network-based neighborhood regression framework whose regression functions depend on both the global community-level information and local connectivity structures among entities. An efficient community-wise least square optimization approach is developed to uncover the strength of regulation among the network modules while enabling asymptotic inference. With random graph theory, we derive non-asymptotic estimation error bounds for the proposed estimator, achieving exact minimax optimality. Unlike the root-n consistency typical in canonical linear regression, our model exhibits linear consistency in the number of nodes n, highlighting the advantage of incorporating neighborhood information. The effectiveness of the proposed framework is further supported by extensive numerical experiments. Application to whole-exome sequencing and RNA-sequencing Autism datasets demonstrates the usage of the proposed method in identifying the association between the gene modules of genetic variations and the gene modules of genomic differential expressions.

Hallucinations -- the generation of untrue claims -- pose a challenge to the application of large language models (LLMs) [1] thereby motivating the development of metrics to evaluate factual precision. We observe that popular metrics using the Decompose-Then-Verify framework, such as FActScore [2], can be manipulated by adding obvious or repetitive claims to artificially inflate scores. We expand the FActScore dataset to design and analyze factual precision metrics, demonstrating that models can be trained to achieve high scores under existing metrics through exploiting the issues we identify. This motivates our new customizable plug-and-play subclaim selection component called Core, which filters down individual subclaims according to their uniqueness and informativeness. Metrics augmented by Core are substantially more robust as shown in head-to-head comparisons. We release an evaluation framework supporting the modular use of Core (https://github.com/zipJiang/Core) and various decomposition strategies, and we suggest its adoption by the LLM community. [1] Hong et al., "The Hallucinations Leaderboard -- An Open Effort to Measure Hallucinations in Large Language Models", arXiv:2404.05904v2 [cs.CL]. [2] Min et al., "FActScore: Fine-grained Atomic Evaluation of Factual Precision in Long Form Text Generation", arXiv:2305.14251v2 [cs.CL].

Although engagement in self-directed wellness exercises typically declines over time, integrating social support such as coaching can sustain it. However, traditional forms of support are often inaccessible due to the high costs and complex coordination. Large Language Models (LLMs) show promise in providing human-like dialogues that could emulate social support. Yet, in-depth, in situ investigations of LLMs to support behavior change remain underexplored. We conducted two randomized experiments to assess the impact of LLM agents on user engagement with mindfulness exercises. First, a single-session study, involved 502 crowdworkers; second, a three-week study, included 54 participants. We explored two types of LLM agents: one providing information and another facilitating self-reflection. Both agents enhanced users' intentions to practice mindfulness. However, only the information-providing LLM, featuring a friendly persona, significantly improved engagement with the exercises. Our findings suggest that specific LLM agents may bridge the social support gap in digital health interventions.

While standard evaluation scores for generative models are mostly reference-based, a reference-dependent assessment of generative models could be generally difficult due to the unavailability of applicable reference datasets. Recently, the reference-free entropy scores, VENDI and RKE, have been proposed to evaluate the diversity of generated data. However, estimating these scores from data leads to significant computational costs for large-scale generative models. In this work, we leverage the random Fourier features framework to reduce the computational price and propose the Fourier-based Kernel Entropy Approximation (FKEA) method. We utilize FKEA's approximated eigenspectrum of the kernel matrix to efficiently estimate the mentioned entropy scores. Furthermore, we show the application of FKEA's proxy eigenvectors to reveal the method's identified modes in evaluating the diversity of produced samples. We provide a stochastic implementation of the FKEA assessment algorithm with a complexity $O(n)$ linearly growing with sample size $n$. We extensively evaluate FKEA's numerical performance in application to standard image, text, and video datasets. Our empirical results indicate the method's scalability and interpretability applied to large-scale generative models. The codebase is available at https://github.com/aziksh-ospanov/FKEA.

Large language models (LLMs) are used for long-form question answering (LFQA), which requires them to generate paragraph-length answers to complex questions. While LFQA has been well-studied in English, this research has not been extended to other languages. To bridge this gap, we introduce CaLMQA, a collection of 1.5K complex culturally specific questions spanning 23 languages and 51 culturally agnostic questions translated from English into 22 other languages. We define culturally specific questions as those uniquely or more likely to be asked by people from cultures associated with the question's language. We collect naturally-occurring questions from community web forums and hire native speakers to write questions to cover under-resourced, rarely-studied languages such as Fijian and Kirundi. Our dataset contains diverse, complex questions that reflect cultural topics (e.g. traditions, laws, news) and the language usage of native speakers. We automatically evaluate a suite of open- and closed-source models on CaLMQA by detecting incorrect language and token repetitions in answers, and observe that the quality of LLM-generated answers degrades significantly for some low-resource languages. Lastly, we perform human evaluation on a subset of models and languages. Manual evaluation reveals that model performance is significantly worse for culturally specific questions than for culturally agnostic questions. Our findings highlight the need for further research in non-English LFQA and provide an evaluation framework.

Pre-trained models produce strong generic representations that can be adapted via fine-tuning. The learned weight difference relative to the pre-trained model, known as a task vector, characterises the direction and stride of fine-tuning. The significance of task vectors is such that simple arithmetic operations on them can be used to combine diverse representations from different domains. This paper builds on these properties of task vectors and aims to answer (1) whether components of task vectors, particularly parameter blocks, exhibit similar characteristics, and (2) how such blocks can be used to enhance knowledge composition and transfer. To this end, we introduce aTLAS, an algorithm that linearly combines parameter blocks with different learned coefficients, resulting in anisotropic scaling at the task vector level. We show that such linear combinations explicitly exploit the low intrinsic dimensionality of pre-trained models, with only a few coefficients being the learnable parameters. Furthermore, composition of parameter blocks leverages the already learned representations, thereby reducing the dependency on large amounts of data. We demonstrate the effectiveness of our method in task arithmetic, few-shot recognition and test-time adaptation, with supervised or unsupervised objectives. In particular, we show that (1) learned anisotropic scaling allows task vectors to be more disentangled, causing less interference in composition; (2) task vector composition excels with scarce or no labeled data and is less prone to domain shift, thus leading to better generalisability; (3) mixing the most informative parameter blocks across different task vectors prior to training can reduce the memory footprint and improve the flexibility of knowledge transfer. Moreover, we show the potential of aTLAS as a PEFT method, particularly with less data, and demonstrate that its scalibility.

Recent work shows Large Language Models (LLMs) struggle to understand natural language constraints for various text generation tasks in zero- and few-shot settings. While, in the code domain, there is wide usage of constraints in code format to maintain the integrity of code written in Domain-Specific Languages (DSLs), yet there has been no work evaluating LLMs with these constraints. We propose two novel tasks to assess the controllability of LLMs using hard and soft constraints represented as code across five representations. Our findings suggest that LLMs struggle to comprehend constraints in all representations irrespective of their portions in the pre-training data. While models are better at comprehending constraints in JSON, YAML, and natural language representations, they struggle with constraints represented in XML and the resource-rich language Python.

Vision-Language Models (VLMs) demonstrate remarkable zero-shot generalization to unseen tasks, but fall short of the performance of supervised methods in generalizing to downstream tasks with limited data. Prompt learning is emerging as a parameter-efficient method for adapting VLMs, but state-of-the-art approaches require annotated samples. In this paper we propose a novel approach to prompt learning based on unsupervised knowledge distillation from more powerful models. Our approach, which we call Knowledge Distillation Prompt Learning (KDPL), can be integrated into existing prompt learning techniques and eliminates the need for labeled examples during adaptation. Our experiments on more than ten standard benchmark datasets demonstrate that KDPL is very effective at improving generalization of learned prompts for zero-shot domain generalization, zero-shot cross-dataset generalization, and zero-shot base-to-novel class generalization problems. KDPL requires no ground-truth labels for adaptation, and moreover we show that even in the absence of any knowledge of training class names it can be used to effectively transfer knowledge. The code is publicly available at https://github.com/miccunifi/KDPL.

Tool learning methods have enhanced the ability of large language models (LLMs) to interact with real-world applications. Many existing works fine-tune LLMs or design prompts to enable LLMs to select appropriate tools and correctly invoke them to meet user requirements. However, it is observed in previous works that the performance of tool learning varies from tasks, datasets, training settings, and algorithms. Without understanding the impact of these factors, it can lead to inconsistent results, inefficient model deployment, and suboptimal tool utilization, ultimately hindering the practical integration and scalability of LLMs in real-world scenarios. Therefore, in this paper, we explore the impact of both internal and external factors on the performance of tool learning frameworks. Through extensive experiments on two benchmark datasets, we find several insightful conclusions for future work, including the observation that LLMs can benefit significantly from increased trial and exploration. We believe our empirical study provides a new perspective for future tool learning research.

Is explainability a false promise? This debate has emerged from the insufficient evidence that explanations aid people in situations they are introduced for. More human-centered, application-grounded evaluations of explanations are needed to settle this. Yet, with no established guidelines for such studies in NLP, researchers accustomed to standardized proxy evaluations must discover appropriate measurements, tasks, datasets, and sensible models for human-AI teams in their studies. To help with this, we first review fitting existing metrics. We then establish requirements for datasets to be suitable for application-grounded evaluations. Among over 50 datasets available for explainability research in NLP, we find that 4 meet our criteria. By finetuning Flan-T5-3B, we demonstrate the importance of reassessing the state of the art to form and study human-AI teams. Finally, we present the exemplar studies of human-AI decision-making for one of the identified suitable tasks -- verifying the correctness of a legal claim given a contract.