A growing number of Americans are seeing their job security erode in the face of automation and it's undermining their health, according to a new study. The report, conducted by three Ball State University researchers with the school's Center for Business and Economic Research, shows that a 10 percentage point increase in automation risk increases average per-county costs related to medical expenses and lost productivity. "People who live and work in areas where automation is taking place are sickened by the thought of losing their jobs and having no way of providing for themselves or their families," said Michael Hicks, the center's director, who helped conduct the research. Costs associated with an increase in poor or fair health rise by $24 million to $174 million, costs related to increased physical distress rise by $6 million to $40 million and costs linked to mental distress increase by $7 million to $47 million. "This should give us pause about thinking through the benefits and costs of these technologies," Hicks said.

On August 8th, 2021, Spanish police and customs agents intercepted the cargo ship NATALIA on suspicion of narcotics trafficking. The ship was en route from Lebanon via Iskenderun, Turkey, to Lagos, Nigeria, and hidden on board was nearly 20 tons of hashish worth $470 million. That may sound like the opening scene of an action flick, but it's the kind of occurrence that happens more frequently than you might expect on the high seas. Drug smuggling, illegal fishing, and piracy are constant threats. Following a number of recent piracy incidents in the Gulf of Aden, Iran, Russia, and China recently began naval and air drills seeking to counter maritime piracy.

Histological staining is the gold standard for tissue examination in clinical pathology and life-science research, which visualizes the tissue and cellular structures using chromatic dyes or fluorescence labels to aid the microscopic assessment of tissue. However, the current histological staining workflow requires tedious sample preparation steps, specialized laboratory infrastructure, and trained histotechnologists, making it expensive, time-consuming, and not accessible in resource-limited settings. Deep learning techniques created new opportunities to revolutionize staining methods by digitally generating histological stains using trained neural networks, providing rapid, cost-effective, and accurate alternatives to standard chemical staining methods. These techniques, broadly referred to as virtual staining, were extensively explored by multiple research groups and demonstrated to be successful in generating various types of histological stains from label-free microscopic images of unstained samples; similar approaches were also used for transforming images of an already stained tissue sample into another type of stain, performing virtual stain-to-stain transformations. In this Review, we provide a comprehensive overview of the recent research advances in deep learning-enabled virtual histological staining techniques. The basic concepts and the typical workflow of virtual staining are introduced, followed by a discussion of representative works and their technical innovations. We also share our perspectives on the future of this emerging field, aiming to inspire readers from diverse scientific fields to further expand the scope of deep learning-enabled virtual histological staining techniques and their applications.

Pretrained language models (PLMs) have been shown to accumulate factual knowledge during pretrainingng (Petroni et al., 2019). Recent works probe PLMs for the extent of this knowledge through prompts either in discrete or continuous forms. However, these methods do not consider symmetry of the task: object prediction and subject prediction. In this work, we propose Symmetrical Prompt Enhancement (SPE), a continuous prompt-based method for factual probing in PLMs that leverages the symmetry of the task by constructing symmetrical prompts for subject and object prediction. Our results on a popular factual probing dataset, LAMA, show significant improvement of SPE over previous probing methods.

Conditional Independence (CI) graphs are a type of probabilistic graphical models that are primarily used to gain insights about feature relationships. Each edge represents the partial correlation between the connected features which gives information about their direct dependence. In this survey, we list out different methods and study the advances in techniques developed to recover CI graphs. We cover traditional optimization methods as well as recently developed deep learning architectures along with their recommended implementations. To facilitate wider adoption, we include preliminaries that consolidate associated operations, for example techniques to obtain covariance matrix for mixed datatypes. It is often beneficial to know which features are directly correlated to which other features. This can help us understand the input data better by giving a feature inter-dependence overview and also assist in taking system design decisions.

Statistical analysis of tensor-valued data has largely used the tensor-variate normal (TVN) distribution that may be inadequate when data comes from distributions with heavier or lighter tails. We study a general family of elliptically contoured (EC) tensor-variate distributions and derive its characterizations, moments, marginal and conditional distributions, and the EC Wishart distribution. We describe procedures for maximum likelihood estimation from data that are (1) uncorrelated draws from an EC distribution, (2) from a scale mixture of the TVN distribution, and (3) from an underlying but unknown EC distribution, where we extend Tyler's robust estimator. A detailed simulation study highlights the benefits of choosing an EC distribution over the TVN for heavier-tailed data. We develop tensor-variate classification rules using discriminant analysis and EC errors and show that they better predict cats and dogs from images in the Animal Faces-HQ dataset than the TVN-based rules. A novel tensor-on-tensor regression and tensor-variate analysis of variance (TANOVA) framework under EC errors is also demonstrated to better characterize gender, age and ethnic origin than the usual TVN-based TANOVA in the celebrated Labeled Faces of the Wild dataset.

This paper describes my participation in the SemEval-2022 Task 4: Patronizing and Condescending Language Detection. I participate in both subtasks: Patronizing and Condescending Language (PCL) Identification and Patronizing and Condescending Language Categorization, with the main focus put on subtask 1. The experiments compare pre-BERT neural network (NN) based systems against post-BERT pretrained language model RoBERTa. This research finds NN-based systems in the experiments perform worse on the task compared to the pretrained language models. The top-performing RoBERTa system is ranked 26 out of 78 teams (F1-score: 54.64) in subtask 1, and 23 out of 49 teams (F1-score: 30.03) in subtask 2.

Recently, prompt tuning (PT) has gained increasing attention as a parameter-efficient way of tuning pre-trained language models (PLMs). Despite extensively reducing the number of tunable parameters and achieving satisfying performance, PT is training-inefficient due to its slow convergence. To improve PT's training efficiency, we first make some novel observations about the prompt transferability of "partial PLMs", which are defined by compressing a PLM in depth or width. We observe that the soft prompts learned by different partial PLMs of various sizes are similar in the parameter space, implying that these soft prompts could potentially be transferred among partial PLMs. Inspired by these observations, we propose Fast Prompt Tuning (FPT), which starts by conducting PT using a small-scale partial PLM, and then progressively expands its depth and width until the full-model size. After each expansion, we recycle the previously learned soft prompts as initialization for the enlarged partial PLM and then proceed PT. We demonstrate the feasibility of FPT on 5 tasks and show that FPT could save over 30% training computations while achieving comparable performance.

Characterizing the differential excision of mRNA is critical for understanding the functional complexity of a cell or tissue, from normal developmental processes to disease pathogenesis. Most transcript reconstruction methods infer full-length transcripts from high-throughput sequencing data. However, this is a challenging task due to incomplete annotations and the differential expression of transcripts across cell-types, tissues, and experimental conditions. Several recent methods circumvent these difficulties by considering local splicing events, but these methods lose transcript-level splicing information and may conflate transcripts. We develop the first probabilistic model that reconciles the transcript and local splicing perspectives. First, we formalize the sequence of mRNA excisions (SME) reconstruction problem, which aims to assemble variable-length sequences of mRNA excisions from RNA-sequencing data. We then present a novel hierarchical Bayesian admixture model for the Reconstruction of Excised mRNA (BREM). BREM interpolates between local splicing events and full-length transcripts and thus focuses only on SMEs that have high posterior probability. We develop posterior inference algorithms based on Gibbs sampling and local search of independent sets and characterize differential SME usage using generalized linear models based on converged BREM model parameters. We show that BREM achieves higher F1 score for reconstruction tasks and improved accuracy and sensitivity in differential splicing when compared with four state-of-the-art transcript and local splicing methods on simulated data. Lastly, we evaluate BREM on both bulk and scRNA sequencing data based on transcript reconstruction, novelty of transcripts produced, model sensitivity to hyperparameters, and a functional analysis of differentially expressed SMEs, demonstrating that BREM captures relevant biological signal.

The subject of conversational mining has become of great interest recently due to the explosion of social and other online media. Supplementing this explosion of text is the advancement in pre-trained language models which have helped us to leverage these sources of information. An interesting domain to analyse is conversations in terms of complexity and value. Complexity arises due to the fact that a conversation can be asynchronous and can involve multiple parties. It is also computationally intensive to process. We use unsupervised methods in our work in order to develop a conversational pattern mining technique which does not require time consuming, knowledge demanding and resource intensive labelling exercises. The task of identifying repeating patterns in sequences is well researched in the Bioinformatics field. In our work, we adapt this to the field of Natural Language Processing and make several extensions to a motif detection algorithm. In order to demonstrate the application of the algorithm on a dynamic, real world data set; we extract motifs from an open-source film script data source. We run an exploratory investigation into the types of motifs we are able to mine.