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Evaluating the Effectiveness of Artificial Intelligence in Predicting Adverse Drug Reactions among Cancer Patients: A Systematic Review and Meta-Analysis

arXiv.org Artificial Intelligence

Adverse drug reactions considerably impact patient outcomes and healthcare costs in cancer therapy. Using artificial intelligence to predict adverse drug reactions in real time could revolutionize oncology treatment. This study aims to assess the performance of artificial intelligence models in predicting adverse drug reactions in patients with cancer. This is the first systematic review and meta-analysis. Scopus, PubMed, IEEE Xplore, and ACM Digital Library databases were searched for studies in English, French, and Arabic from January 1, 2018, to August 20, 2023. The inclusion criteria were: (1) peer-reviewed research articles; (2) use of artificial intelligence algorithms (machine learning, deep learning, knowledge graphs); (3) study aimed to predict adverse drug reactions (cardiotoxicity, neutropenia, nephrotoxicity, hepatotoxicity); (4) study was on cancer patients. The data were extracted and evaluated by three reviewers for study quality. Of the 332 screened articles, 17 studies (5%) involving 93,248 oncology patients from 17 countries were included in the systematic review, of which ten studies synthesized the meta-analysis. A random-effects model was created to pool the sensitivity, specificity, and AUC of the included studies. The pooled results were 0.82 (95% CI:0.69, 0.9), 0.84 (95% CI:0.75, 0.9), and 0.83 (95% CI:0.77, 0.87) for sensitivity, specificity, and AUC, respectively, of ADR predictive models. Biomarkers proved their effectiveness in predicting ADRs, yet they were adopted by only half of the reviewed studies. The use of AI in cancer treatment shows great potential, with models demonstrating high specificity and sensitivity in predicting ADRs. However, standardized research and multicenter studies are needed to improve the quality of evidence. AI can enhance cancer patient care by bridging the gap between data-driven insights and clinical expertise.


Soft-Prompting with Graph-of-Thought for Multi-modal Representation Learning

arXiv.org Artificial Intelligence

The chain-of-thought technique has been received well in multi-modal tasks. It is a step-by-step linear reasoning process that adjusts the length of the chain to improve the performance of generated prompts. However, human thought processes are predominantly non-linear, as they encompass multiple aspects simultaneously and employ dynamic adjustment and updating mechanisms. Therefore, we propose a novel Aggregation-Graph-of-Thought (AGoT) mechanism for soft-prompt tuning in multi-modal representation learning. The proposed AGoT models the human thought process not only as a chain but also models each step as a reasoning aggregation graph to cope with the overlooked multiple aspects of thinking in single-step reasoning. This turns the entire reasoning process into prompt aggregation and prompt flow operations. Experiments show that our multi-modal model enhanced with AGoT soft-prompting achieves good results in several tasks such as text-image retrieval, visual question answering, and image recognition. In addition, we demonstrate that it has good domain generalization performance due to better reasoning.


Multilingual Brain Surgeon: Large Language Models Can be Compressed Leaving No Language Behind

arXiv.org Artificial Intelligence

Large Language Models (LLMs) have ushered in a new era in Natural Language Processing, but their massive size demands effective compression techniques for practicality. Although numerous model compression techniques have been investigated, they typically rely on a calibration set that overlooks the multilingual context and results in significant accuracy degradation for low-resource languages. This paper introduces Multilingual Brain Surgeon (MBS), a novel calibration data sampling method for multilingual LLMs compression. MBS overcomes the English-centric limitations of existing methods by sampling calibration data from various languages proportionally to the language distribution of the model training datasets. Our experiments, conducted on the BLOOM multilingual LLM, demonstrate that MBS improves the performance of existing English-centric compression methods, especially for low-resource languages. We also uncover the dynamics of language interaction during compression, revealing that the larger the proportion of a language in the training set and the more similar the language is to the calibration language, the better performance the language retains after compression. In conclusion, MBS presents an innovative approach to compressing multilingual LLMs, addressing the performance disparities and improving the language inclusivity of existing compression techniques.


Sentiment Analysis of Citations in Scientific Articles Using ChatGPT: Identifying Potential Biases and Conflicts of Interest

arXiv.org Artificial Intelligence

Scientific articles play a crucial role in advancing knowledge and informing research directions. One key aspect of evaluating scientific articles is the analysis of citations, which provides insights into the impact and reception of the cited works. This article introduces the innovative use of large language models, particularly ChatGPT, for comprehensive sentiment analysis of citations within scientific articles. By leveraging advanced natural language processing (NLP) techniques, ChatGPT can discern the nuanced positivity or negativity of citations, offering insights into the reception and impact of cited works. Furthermore, ChatGPT's capabilities extend to detecting potential biases and conflicts of interest in citations, enhancing the objectivity and reliability of scientific literature evaluation. This study showcases the transformative potential of artificial intelligence (AI)-powered tools in enhancing citation analysis and promoting integrity in scholarly research.


The Identification and Categorization of Anemia Through Artificial Neural Networks: A Comparative Analysis of Three Models

arXiv.org Artificial Intelligence

This paper presents different neural network-based classifier algorithms for diagnosing and classifying Anemia. The study compares these classifiers with established models such as Feed Forward Neural Network (FFNN), Elman network, and Non-linear Auto-Regressive Exogenous model (NARX). Experimental evaluations were conducted using data from clinical laboratory test results for 230 patients. The proposed neural network features nine inputs (age, gender, RBC, HGB, HCT, MCV, MCH, MCHC, WBCs) and one output. The simulation outcomes for diverse patients demonstrate that the suggested artificial neural network rapidly and accurately detects the presence of the disease. Consequently, the network could be seamlessly integrated into clinical laboratories for automatic generation of Anemia patients' reports Additionally, the suggested method is affordable and can be deployed on hardware at low costs.


What Happens When Small Is Made Smaller? Exploring the Impact of Compression on Small Data Pretrained Language Models

arXiv.org Artificial Intelligence

Compression techniques have been crucial in advancing machine learning by enabling efficient training and deployment of large-scale language models. However, these techniques have received limited attention in the context of low-resource language models, which are trained on even smaller amounts of data and under computational constraints, a scenario known as the "low-resource double-bind." This paper investigates the effectiveness of pruning, knowledge distillation, and quantization on an exclusively low-resourced, small-data language model, AfriBERTa. Through a battery of experiments, we assess the effects of compression on performance across several metrics beyond accuracy. Our study provides evidence that compression techniques significantly improve the efficiency and effectiveness of small-data language models, confirming that the prevailing beliefs regarding the effects of compression on large, heavily parameterized models hold true for less-parameterized, small-data models.


Automatic Alignment of Discourse Relations of Different Discourse Annotation Frameworks

arXiv.org Artificial Intelligence

Existing discourse corpora are annotated based on different frameworks, which show significant dissimilarities in definitions of arguments and relations and structural constraints. Despite surface differences, these frameworks share basic understandings of discourse relations. The relationship between these frameworks has been an open research question, especially the correlation between relation inventories utilized in different frameworks. Better understanding of this question is helpful for integrating discourse theories and enabling interoperability of discourse corpora annotated under different frameworks. However, studies that explore correlations between discourse relation inventories are hindered by different criteria of discourse segmentation, and expert knowledge and manual examination are typically needed. Some semi-automatic methods have been proposed, but they rely on corpora annotated in multiple frameworks in parallel. In this paper, we introduce a fully automatic approach to address the challenges. Specifically, we extend the label-anchored contrastive learning method introduced by Zhang et al. (2022b) to learn label embeddings during a classification task. These embeddings are then utilized to map discourse relations from different frameworks. We show experimental results on RST-DT (Carlson et al., 2001) and PDTB 3.0 (Prasad et al., 2018).


PoLLMgraph: Unraveling Hallucinations in Large Language Models via State Transition Dynamics

arXiv.org Artificial Intelligence

Despite tremendous advancements in large language models (LLMs) over recent years, a notably urgent challenge for their practical deployment is the phenomenon of hallucination, where the model fabricates facts and produces non-factual statements. In response, we propose PoLLMgraph, a Polygraph for LLMs, as an effective model-based white-box detection and forecasting approach. PoLLMgraph distinctly differs from the large body of existing research that concentrates on addressing such challenges through black-box evaluations. In particular, we demonstrate that hallucination can be effectively detected by analyzing the LLM's internal state transition dynamics during generation via tractable probabilistic models. Experimental results on various open-source LLMs confirm the efficacy of PoLLMgraph, outperforming state-of-the-art methods by a considerable margin, evidenced by over 20% improvement in AUC-ROC on common benchmarking datasets like TruthfulQA. Our work paves a new way for model-based white-box analysis of LLMs, motivating the research community to further explore, understand, and refine the intricate dynamics of LLM behaviors.


Multilingual Pretraining and Instruction Tuning Improve Cross-Lingual Knowledge Alignment, But Only Shallowly

arXiv.org Artificial Intelligence

Despite their strong ability to retrieve knowledge in English, current large language models show imbalance abilities in different languages. Two approaches are proposed to address this, i.e., multilingual pretraining and multilingual instruction tuning. However, whether and how do such methods contribute to the cross-lingual knowledge alignment inside the models is unknown. In this paper, we propose CLiKA, a systematic framework to assess the cross-lingual knowledge alignment of LLMs in the Performance, Consistency and Conductivity levels, and explored the effect of multilingual pretraining and instruction tuning on the degree of alignment. Results show that: while both multilingual pretraining and instruction tuning are beneficial for cross-lingual knowledge alignment, the training strategy needs to be carefully designed. Namely, continued pretraining improves the alignment of the target language at the cost of other languages, while mixed pretraining affect other languages less. Also, the overall cross-lingual knowledge alignment, especially in the conductivity level, is unsatisfactory for all tested LLMs, and neither multilingual pretraining nor instruction tuning can substantially improve the cross-lingual knowledge conductivity.


Denmark's top military chief dismissed after incident involving ship deployed to Red Sea

FOX News

Fox News chief national security correspondent Jennifer Griffin reports on how autonomous weapons used in Ukraine have transformed the battlefield on'Special Report.' A series of scandals has blighted Denmark's Armed Forces at a time when the Scandinavian country and member of the NATO alliance is building up its defenses, chiefly as a response to Russia's invasion of Ukraine. The events have so far led to the dismissal this week of Denmark's top military chief, Gen. Flemming Lentfer, who failed to inform the defense minister about an incident on the frigate HDMS Iver Huitfeldt last month while deployed to the Red Sea, where it was part of a U.S.-led operation to defend commercial shipping against Houthi militants. On Thursday, a technical error onboard its sister ship, the frigate HDMS Niels Juel that was docked in a Danish harbor, led to the air space and maritime route being briefly closed due to fears a navy missile might launch unintentionally -- but not explode -- and send fragments falling into the busy shipping lane between the islands of Zeeland, where Copenhagen sits, and Funen. The Iver Huitfeldt, which returned from its Red Sea mission on Thursday, ahead of schedule, reportedly experienced a half-hour long malfunction of its missile and radar systems during a drone attack on March 9, according to the specialist defense news website Olfi.