Given unstructured text, Large Language Models (LLMs) are adept at answering simple (single-hop) questions. However, as the complexity of the questions increase, the performance of LLMs degrade. We believe this is due to the overhead associated with understanding the complex question followed by filtering and aggregating unstructured information in the raw text. Recent methods try to reduce this burden by integrating structured knowledge triples into the raw text, aiming to provide a structured overview that simplifies information processing. However, this simplistic approach is query-agnostic and the extracted facts are ambiguous as they lack context. To address these drawbacks and to enable LLMs to answer complex (multi-hop) questions with ease, we propose to use a knowledge graph (KG) that is context-aware and is distilled to contain query-relevant information. The use of our compressed distilled KG as input to the LLM results in our method utilizing up to $67\%$ fewer tokens to represent the query relevant information present in the supporting documents, compared to the state-of-the-art (SoTA) method. Our experiments show consistent improvements over the SoTA across several metrics (EM, F1, BERTScore, and Human Eval) on two popular benchmark datasets (HotpotQA and MuSiQue).

Semantic information is vital for human interaction, and decoding it from brain activity enables non-invasive clinical augmentative and alternative communication. While there has been significant progress in reconstructing visual images, few studies have focused on the language aspect. To address this gap, leveraging the powerful capabilities of the decoder-based vision-language pretrained model CoCa, this paper proposes BrainChat, a simple yet effective generative framework aimed at rapidly accomplishing semantic information decoding tasks from brain activity, including fMRI question answering and fMRI captioning. BrainChat employs the self-supervised approach of Masked Brain Modeling to encode sparse fMRI data, obtaining a more compact embedding representation in the latent space. Subsequently, BrainChat bridges the gap between modalities by applying contrastive loss, resulting in aligned representations of fMRI, image, and text embeddings. Furthermore, the fMRI embeddings are mapped to the generative Brain Decoder via cross-attention layers, where they guide the generation of textual content about fMRI in a regressive manner by minimizing caption loss. Empirically, BrainChat exceeds the performance of existing state-of-the-art methods in the fMRI captioning task and, for the first time, implements fMRI question answering. Additionally, BrainChat is highly flexible and can achieve high performance without image data, making it better suited for real-world scenarios with limited data.

Instruction-finetuned code language models (LMs) have shown promise in various programming tasks. They are trained, using a language modeling objective, on natural language instructions and gold code snippet pairs. Recent evidence suggests that these models, never exposed to incorrect solutions during training, often struggle to distinguish between correct and incorrect solutions. This observation raises our inquiry: Can preference learning, which trains models to prefer correct solutions over incorrect ones, help push the boundaries of code LMs even further? We propose PLUM, a novel \textbf{p}reference \textbf{l}earning framework a\textbf{u}gmented with test cases tailored for code L\textbf{M}s.PLUM aims to investigate the key success factors and potential benefits of preference learning in code LMs, which remain elusive despite its success in aligning LMs with human values. PLUM consists of three stages: (1) Generating test cases for natural language instructions, (2) sampling candidate solutions from the policy and evaluating them against the test cases to create a preference dataset, which is then used to (3) train the policy with a preference learning algorithm. Experiments demonstrate that PLUM substantially improves the performance of existing code LMs on established code generation benchmarks such as HumanEval (+) and MBPP (+), even for the state-of-the-art open-source language model CodeQwen-1.5-7B-Chat. PLUM complements the supervised fine-tuning (SFT) stage, demonstrating synergistic effects.

Question answering systems (QA) utilizing Large Language Models (LLMs) heavily depend on the retrieval component to provide them with domain-specific information and reduce the risk of generating inaccurate responses or hallucinations. Although the evaluation of retrievers dates back to the early research in Information Retrieval, assessing their performance within LLM-based chatbots remains a challenge. This study proposes a straightforward baseline for evaluating retrievers in Retrieval-Augmented Generation (RAG)-based chatbots. Our findings demonstrate that this evaluation framework provides a better image of how the retriever performs and is more aligned with the overall performance of the QA system. Although conventional metrics such as precision, recall, and F1 score may not fully capture LLMs' capabilities - as they can yield accurate responses despite imperfect retrievers - our method considers LLMs' strengths to ignore irrelevant contexts, as well as potential errors and hallucinations in their responses.

Over 85 million computed tomography (CT) scans are performed annually in the US, of which approximately one quarter focus on the abdomen. Given the current radiologist shortage, there is a large impetus to use artificial intelligence to alleviate the burden of interpreting these complex imaging studies. Prior state-of-the-art approaches for automated medical image interpretation leverage vision language models (VLMs). However, current medical VLMs are generally limited to 2D images and short reports, and do not leverage electronic health record (EHR) data for supervision. We introduce Merlin - a 3D VLM that we train using paired CT scans (6+ million images from 15,331 CTs), EHR diagnosis codes (1.8+ million codes), and radiology reports (6+ million tokens). We evaluate Merlin on 6 task types and 752 individual tasks. The non-adapted (off-the-shelf) tasks include zero-shot findings classification (31 findings), phenotype classification (692 phenotypes), and zero-shot cross-modal retrieval (image to findings and image to impressions), while model adapted tasks include 5-year disease prediction (6 diseases), radiology report generation, and 3D semantic segmentation (20 organs). We perform internal validation on a test set of 5,137 CTs, and external validation on 7,000 clinical CTs and on two public CT datasets (VerSe, TotalSegmentator). Beyond these clinically-relevant evaluations, we assess the efficacy of various network architectures and training strategies to depict that Merlin has favorable performance to existing task-specific baselines. We derive data scaling laws to empirically assess training data needs for requisite downstream task performance. Furthermore, unlike conventional VLMs that require hundreds of GPUs for training, we perform all training on a single GPU.

Federated learning is a machine learning approach where multiple devices collaboratively learn with the help of a parameter server by sharing only their local updates. While gradient-based optimization techniques are widely adopted in this domain, the curvature information that second-order methods exhibit is crucial to guide and speed up the convergence. This paper introduces a scalable second-order method, allowing the adoption of curvature information in federated large models. Our method, coined Fed-Sophia, combines a weighted moving average of the gradient with a clipping operation to find the descent direction. In addition to that, a lightweight estimation of the Hessian's diagonal is used to incorporate the curvature information. Numerical evaluation shows the superiority, robustness, and scalability of the proposed Fed-Sophia scheme compared to first and second-order baselines.

Probabilistic integral circuits (PICs) have been recently introduced as probabilistic models enjoying the key ingredient behind expressive generative models: continuous latent variables (LVs). PICs are symbolic computational graphs defining continuous LV models as hierarchies of functions that are summed and multiplied together, or integrated over some LVs. They are tractable if LVs can be analytically integrated out, otherwise they can be approximated by tractable probabilistic circuits (PC) encoding a hierarchical numerical quadrature process, called QPCs. So far, only tree-shaped PICs have been explored, and training them via numerical quadrature requires memory-intensive processing at scale. In this paper, we address these issues, and present: (i) a pipeline for building DAG-shaped PICs out of arbitrary variable decompositions, (ii) a procedure for training PICs using tensorized circuit architectures, and (iii) neural functional sharing techniques to allow scalable training.

Developing therapeutics is a lengthy and expensive process that requires the satisfaction of many different criteria, and AI models capable of expediting the process would be invaluable. However, the majority of current AI approaches address only a narrowly defined set of tasks, often circumscribed within a particular domain. To bridge this gap, we introduce Tx-LLM, a generalist large language model (LLM) fine-tuned from PaLM-2 which encodes knowledge about diverse therapeutic modalities. Tx-LLM is trained using a collection of 709 datasets that target 66 tasks spanning various stages of the drug discovery pipeline. Using a single set of weights, Tx-LLM simultaneously processes a wide variety of chemical or biological entities(small molecules, proteins, nucleic acids, cell lines, diseases) interleaved with free-text, allowing it to predict a broad range of associated properties, achieving competitive with state-of-the-art (SOTA) performance on 43 out of 66 tasks and exceeding SOTA on 22. Among these, Tx-LLM is particularly powerful and exceeds best-in-class performance on average for tasks combining molecular SMILES representations with text such as cell line names or disease names, likely due to context learned during pretraining. We observe evidence of positive transfer between tasks with diverse drug types (e.g.,tasks involving small molecules and tasks involving proteins), and we study the impact of model size, domain finetuning, and prompting strategies on performance. We believe Tx-LLM represents an important step towards LLMs encoding biochemical knowledge and could have a future role as an end-to-end tool across the drug discovery development pipeline.

Amid growing concerns over AI's societal risks--ranging from civilizational collapse to misinformation and systemic bias--this study explores the perceptions of AI experts and the general US registered voters on the likelihood and impact of 18 specific AI risks, alongside their policy preferences for managing these risks. While both groups favor international oversight over national or corporate governance, our survey reveals a discrepancy: voters perceive AI risks as both more likely and more impactful than experts, and also advocate for slower AI development. Specifically, our findings indicate that policy interventions may best assuage collective concerns if they attempt to more carefully balance mitigation efforts across all classes of societal-scale risks, effectively nullifying the near-vs-long-term debate over AI risks. More broadly, our results will serve not only to enable more substantive policy discussions for preventing and mitigating AI risks, but also to underscore the challenge of consensus building for effective policy implementation.

Cognitive systems generally require a human to translate a problem definition into some specification that the cognitive system can use to attempt to solve the problem or perform the task. In this paper, we illustrate that large language models (LLMs) can be utilized to map a problem class, defined in natural language, into a semi-formal specification that can then be utilized by an existing reasoning and learning system to solve instances from the problem class. We present the design of LLM-enabled cognitive task analyst agent(s). Implemented with LLM agents, this system produces a definition of problem spaces for tasks specified in natural language. LLM prompts are derived from the definition of problem spaces in the AI literature and general problem-solving strategies (Polya's How to Solve It). A cognitive system can then use the problem-space specification, applying domain-general problem solving strategies ("weak methods" such as search), to solve multiple instances of problems from the problem class. This result, while preliminary, suggests the potential for speeding cognitive systems research via disintermediation of problem formulation while also retaining core capabilities of cognitive systems, such as robust inference and online learning.