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Alchemab Therapeutics Ltd hiring Machine Learning Scientist in Babraham, England, United Kingdom

#artificialintelligence

The candidate will work within the technology team to develop, apply, and design novel machine learning (ML) algorithms with the ultimate aim of discovering therapeutic antibodies from next-generation sequencing (NGS) datasets. The candidate will be involved in multiple projects spanning our oncology, neuroscience, and infectious disease programmes. You will be responsible for the growth and development of our ML product roadmap. This will initially focus on exploiting methods in natural language processing for antibody discovery and patient stratification, and exploring the latest advances in ML (in areas such as self-supervised learning) to extend our capabilities. You will contribute new algorithms and strategies to increase accuracy, explainability, and/or automation of our technology platform.


Forecasting: theory and practice

arXiv.org Machine Learning

Forecasting has always been at the forefront of decision making and planning. The uncertainty that surrounds the future is both exciting and challenging, with individuals and organisations seeking to minimise risks and maximise utilities. The large number of forecasting applications calls for a diverse set of forecasting methods to tackle real-life challenges. This article provides a non-systematic review of the theory and the practice of forecasting. We provide an overview of a wide range of theoretical, state-of-the-art models, methods, principles, and approaches to prepare, produce, organise, and evaluate forecasts. We then demonstrate how such theoretical concepts are applied in a variety of real-life contexts. We do not claim that this review is an exhaustive list of methods and applications. However, we wish that our encyclopedic presentation will offer a point of reference for the rich work that has been undertaken over the last decades, with some key insights for the future of forecasting theory and practice. Given its encyclopedic nature, the intended mode of reading is non-linear. We offer cross-references to allow the readers to navigate through the various topics. We complement the theoretical concepts and applications covered by large lists of free or open-source software implementations and publicly-available databases.


New model improves accuracy of machine learning in COVID-19 diagnosis while preserving privacy

#artificialintelligence

Researchers in the UK and China have developed an artificial intelligence (AI) model that can diagnose COVID-19 as well as a panel of professional radiologists, while preserving the privacy of patient data. The international team, led by the University of Cambridge and the Huazhong University of Science and Technology, used a technique called federated learning to build their model. Using federated learning, an AI model in one hospital or country can be independently trained and verified using a dataset from another hospital or country, without data sharing. The researchers based their model on more than 9,000 CT scans from approximately 3,300 patients in 23 hospitals in the UK and China. Their results, reported in the journal Nature Machine Intelligence, provide a framework where AI techniques can be made more trustworthy and accurate, especially in areas such as medical diagnosis where privacy is vital.


NLP Methods for Extraction of Symptoms from Unstructured Data for Use in Prognostic COVID-19 Analytic Models

Journal of Artificial Intelligence Research

Statistical modeling of outcomes based on a patient's presenting symptoms (symptomatology) can help deliver high quality care and allocate essential resources, which is especially important during the COVID-19 pandemic. Patient symptoms are typically found in unstructured notes, and thus not readily available for clinical decision making. In an attempt to fill this gap, this study compared two methods for symptom extraction from Emergency Department (ED) admission notes. Both methods utilized a lexicon derived by expanding The Center for Disease Control and Prevention's (CDC) Symptoms of Coronavirus list. The first method utilized a word2vec model to expand the lexicon using a dictionary mapping to the Uni ed Medical Language System (UMLS). The second method utilized the expanded lexicon as a rule-based gazetteer and the UMLS. These methods were evaluated against a manually annotated reference (f1-score of 0.87 for UMLS-based ensemble; and 0.85 for rule-based gazetteer with UMLS). Through analyses of associations of extracted symptoms used as features against various outcomes, salient risks among the population of COVID-19 patients, including increased risk of in-hospital mortality (OR 1.85, p-value < 0.001), were identified for patients presenting with dyspnea. Disparities between English and non-English speaking patients were also identified, the most salient being a concerning finding of opposing risk signals between fatigue and in-hospital mortality (non-English: OR 1.95, p-value = 0.02; English: OR 0.63, p-value = 0.01). While use of symptomatology for modeling of outcomes is not unique, unlike previous studies this study showed that models built using symptoms with the outcome of in-hospital mortality were not significantly different from models using data collected during an in-patient encounter (AUC of 0.9 with 95% CI of [0.88, 0.91] using only vital signs; AUC of 0.87 with 95% CI of [0.85, 0.88] using only symptoms). These findings indicate that prognostic models based on symptomatology could aid in extending COVID-19 patient care through telemedicine, replacing the need for in-person options. The methods presented in this study have potential for use in development of symptomatology-based models for other diseases, including for the study of Post-Acute Sequelae of COVID-19 (PASC).


Anticipating Safety Issues in E2E Conversational AI: Framework and Tooling

arXiv.org Artificial Intelligence

Over the last several years, end-to-end neural conversational agents have vastly improved in their ability to carry a chit-chat conversation with humans. However, these models are often trained on large datasets from the internet, and as a result, may learn undesirable behaviors from this data, such as toxic or otherwise harmful language. Researchers must thus wrestle with the issue of how and when to release these models. In this paper, we survey the problem landscape for safety for end-to-end conversational AI and discuss recent and related work. We highlight tensions between values, potential positive impact and potential harms, and provide a framework for making decisions about whether and how to release these models, following the tenets of value-sensitive design. We additionally provide a suite of tools to enable researchers to make better-informed decisions about training and releasing end-to-end conversational AI models.


MOAI: A methodology for evaluating the impact of indoor airflow in the transmission of COVID-19

arXiv.org Machine Learning

Epidemiology models play a key role in understanding and responding to the COVID-19 pandemic. In order to build those models, scientists need to understand contributing factors and their relative importance. A large strand of literature has identified the importance of airflow to mitigate droplets and far-field aerosol transmission risks. However, the specific factors contributing to higher or lower contamination in various settings have not been clearly defined and quantified. As part of the MOAI project (https://moaiapp.com), we are developing a privacy-preserving test and trace app to enable infection cluster investigators to get in touch with patients without having to know their identity. This approach allows involving users in the fight against the pandemic by contributing additional information in the form of anonymous research questionnaires. We first describe how the questionnaire was designed, and the synthetic data was generated based on a review we carried out on the latest available literature. We then present a model to evaluate the risk exposition of a user for a given setting. We finally propose a temporal addition to the model to evaluate the risk exposure over time for a given user.


"Thought I'd Share First": An Analysis of COVID-19 Conspiracy Theories and Misinformation Spread on Twitter

arXiv.org Machine Learning

Background: Misinformation spread through social media is a growing problem, and the emergence of COVID-19 has caused an explosion in new activity and renewed focus on the resulting threat to public health. Given this increased visibility, in-depth analysis of COVID-19 misinformation spread is critical to understanding the evolution of ideas with potential negative public health impact. Methods: Using a curated data set of COVID-19 tweets (N ~120 million tweets) spanning late January to early May 2020, we applied methods including regular expression filtering, supervised machine learning, sentiment analysis, geospatial analysis, and dynamic topic modeling to trace the spread of misinformation and to characterize novel features of COVID-19 conspiracy theories. Results: Random forest models for four major misinformation topics provided mixed results, with narrowly-defined conspiracy theories achieving F1 scores of 0.804 and 0.857, while more broad theories performed measurably worse, with scores of 0.654 and 0.347. Despite this, analysis using model-labeled data was beneficial for increasing the proportion of data matching misinformation indicators. We were able to identify distinct increases in negative sentiment, theory-specific trends in geospatial spread, and the evolution of conspiracy theory topics and subtopics over time. Conclusions: COVID-19 related conspiracy theories show that history frequently repeats itself, with the same conspiracy theories being recycled for new situations. We use a combination of supervised learning, unsupervised learning, and natural language processing techniques to look at the evolution of theories over the first four months of the COVID-19 outbreak, how these theories intertwine, and to hypothesize on more effective public health messaging to combat misinformation in online spaces.


Graph-based Topic Extraction from Vector Embeddings of Text Documents: Application to a Corpus of News Articles

arXiv.org Artificial Intelligence

Production of news content is growing at an astonishing rate. To help manage and monitor the sheer amount of text, there is an increasing need to develop efficient methods that can provide insights into emerging content areas, and stratify unstructured corpora of text into `topics' that stem intrinsically from content similarity. Here we present an unsupervised framework that brings together powerful vector embeddings from natural language processing with tools from multiscale graph partitioning that can reveal natural partitions at different resolutions without making a priori assumptions about the number of clusters in the corpus. We show the advantages of graph-based clustering through end-to-end comparisons with other popular clustering and topic modelling methods, and also evaluate different text vector embeddings, from classic Bag-of-Words to Doc2Vec to the recent transformers based model Bert. This comparative work is showcased through an analysis of a corpus of US news coverage during the presidential election year of 2016.


Machine learning for COVID-19 detection and prognostication using chest radiographs and CT scans: a systematic methodological review

arXiv.org Machine Learning

Background: Machine learning methods offer great potential for fast and accurate detection and prognostication of COVID-19 from standard-of-care chest radiographs (CXR) and computed tomography (CT) images. In this systematic review we critically evaluate the machine learning methodologies employed in the rapidly growing literature. Methods: In this systematic review we reviewed EMBASE via OVID, MEDLINE via PubMed, bioRxiv, medRxiv and arXiv for published papers and preprints uploaded from Jan 1, 2020 to June 24, 2020. Studies which consider machine learning models for the diagnosis or prognosis of COVID-19 from CXR or CT images were included. A methodology quality review of each paper was performed against established benchmarks to ensure the review focusses only on high-quality reproducible papers. This study is registered with PROSPERO [CRD42020188887]. Interpretation: Our review finds that none of the developed models discussed are of potential clinical use due to methodological flaws and underlying biases. This is a major weakness, given the urgency with which validated COVID-19 models are needed. Typically, we find that the documentation of a model's development is not sufficient to make the results reproducible and therefore of 168 candidate papers only 29 are deemed to be reproducible and subsequently considered in this review. We therefore encourage authors to use established machine learning checklists to ensure sufficient documentation is made available, and to follow the PROBAST (prediction model risk of bias assessment tool) framework to determine the underlying biases in their model development process and to mitigate these where possible. This is key to safe clinical implementation which is urgently needed.


GPT-3 Creative Fiction

#artificialintelligence

What if I told a story here, how would that story start?" Thus, the summarization prompt: "My second grader asked me what this passage means: …" When a given prompt isn't working and GPT-3 keeps pivoting into other modes of completion, that may mean that one hasn't constrained it enough by imitating a correct output, and one needs to go further; writing the first few words or sentence of the target output may be necessary.