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MDistMult: A Multiple Scoring Functions Model for Link Prediction on Antiviral Drugs Knowledge Graph

arXiv.org Artificial Intelligence

Knowledge graphs (KGs) on COVID-19 have been constructed to accelerate the research process of COVID-19. However, KGs are always incomplete, especially the new constructed COVID-19 KGs. Link prediction task aims to predict missing entities for (e, r, t) or (h, r, e), where h and t are certain entities, e is an entity that needs to be predicted and r is a relation. This task also has the potential to solve COVID-19 related KGs' incomplete problem. Although various knowledge graph embedding (KGE) approaches have been proposed to the link prediction task, these existing methods suffer from the limitation of using a single scoring function, which fails to capture rich features of COVID-19 KGs. In this work, we propose the MDistMult model that leverages multiple scoring functions to extract more features from existing triples. We employ experiments on the CCKS2020 COVID-19 Antiviral Drugs Knowledge Graph (CADKG). The experimental results demonstrate that our MDistMult achieves state-of-the-art performance in link prediction task on the CADKG dataset


Construct A Biomedical Knowledge Graph With NLP

#artificialintelligence

I have already demonstrated how to create a knowledge graph out of a Wikipedia page. However, since the post got a lot of attention, I've decided to explore other domains where using NLP techniques to construct a knowledge graph makes sense. In my opinion, the biomedical field is a prime example where representing the data as a graph makes sense as you are often analyzing interactions and relations between genes, diseases, drugs, proteins, and more. In the above visualization, we have ascorbic acid, also known as vitamin C, and some of its relations to other concepts. For example, it shows that vitamin C could be used to treat chronic gastritis.


COVID-19 Literature Knowledge Graph Construction and Drug Repurposing Report Generation

arXiv.org Artificial Intelligence

To combat COVID-19, both clinicians and scientists need to digest the vast amount of relevant biomedical knowledge in literature to understand the disease mechanism and the related biological functions. We have developed a novel and comprehensive knowledge discovery framework, \textbf{COVID-KG} to extract fine-grained multimedia knowledge elements (entities, relations and events) from scientific literature. We then exploit the constructed multimedia knowledge graphs (KGs) for question answering and report generation, using drug repurposing as a case study. Our framework also provides detailed contextual sentences, subfigures and knowledge subgraphs as evidence. All of the data, KGs, reports, resources and shared services are publicly available.


Coronavirus Knowledge Graph: A Case Study

arXiv.org Artificial Intelligence

The emergence of the novel COVID-19 pandemic has had a significant impact on global healthcare and the economy over the past few months. The virus's rapid widespread has led to a proliferation in biomedical research addressing the pandemic and its related topics. One of the essential Knowledge Discovery tools that could help the biomedical research community understand and eventually find a cure for COVID-19 are Knowledge Graphs. The CORD-19 dataset is a collection of publicly available full-text research articles that have been recently published on COVID-19 and coronavirus topics. Here, we use several Machine Learning, Deep Learning, and Knowledge Graph construction and mining techniques to formalize and extract insights from the PubMed dataset and the CORD-19 dataset to identify COVID-19 related experts and bio-entities. Besides, we suggest possible techniques to predict related diseases, drug candidates, gene, gene mutations, and related compounds as part of a systematic effort to apply Knowledge Discovery methods to help biomedical researchers tackle the pandemic.