On Wednesday, Anthropic released a report detailing how Claude was misused during March. It revealed some surprising and novel trends in how threat actors and chatbot abuse are evolving and the increasing risks that generative AI poses, even with proper safety testing. In one case, Anthropic found that a "sophisticated actor" had used Claude to help scrape leaked credentials "associated with security cameras" to access the devices, the company noted in the announcement. In another case, an individual with "limited technical skills" could develop malware that normally required more expertise. Claude helped this individual take an open-source kit from doing just the basics to more advanced software functions, like facial recognition and the ability to scan the dark web.

Computational phenotyping is essential for biomedical research but often requires significant time and resources, especially since traditional methods typically involve extensive manual data review. While machine learning and natural language processing advancements have helped, further improvements are needed. Few studies have explored using Large Language Models (LLMs) for these tasks despite known advantages of LLMs for text-based tasks. T o facilitate further research in this area, we developed an evaluation framework, Evaluation of PHEnotyping for Observational Health Data (PHEONA), that outlines context-specific considerations. W e applied and demonstrated PHEONA on concept classification, a specific task within a broader phenotyping process for Acute Respiratory Failure (ARF) respiratory support therapies. From the sample concepts tested, we achieved high classification accuracy, suggesting the potential for LLM-based methods to improve computational phenotyping processes.

The Model Context Protocol (MCP) is a standardized interface designed to enable seamless interaction between AI models and external tools and resources, breaking down data silos and facilitating interoperability across diverse systems. This paper provides a comprehensive overview of MCP, focusing on its core components, workflow, and the lifecycle of MCP servers, which consists of three key phases: creation, operation, and update. We analyze the security and privacy risks associated with each phase and propose strategies to mitigate potential threats. The paper also examines the current MCP landscape, including its adoption by industry leaders and various use cases, as well as the tools and platforms supporting its integration. We explore future directions for MCP, highlighting the challenges and opportunities that will influence its adoption and evolution within the broader AI ecosystem. Finally, we offer recommendations for MCP stakeholders to ensure its secure and sustainable development as the AI landscape continues to evolve.

There is great interest in agentic LLMs, large language models that act as agents. We review the growing body of work in this area and provide a research agenda. Agentic LLMs are LLMs that (1) reason, (2) act, and (3) interact. We organize the literature according to these three categories. The research in the first category focuses on reasoning, reflection, and retrieval, aiming to improve decision making; the second category focuses on action models, robots, and tools, aiming for agents that act as useful assistants; the third category focuses on multi-agent systems, aiming for collaborative task solving and simulating interaction to study emergent social behavior. We find that works mutually benefit from results in other categories: retrieval enables tool use, reflection improves multi-agent collaboration, and reasoning benefits all categories. We discuss applications of agentic LLMs and provide an agenda for further research. Important applications are in medical diagnosis, logistics and financial market analysis. Meanwhile, self-reflective agents playing roles and interacting with one another augment the process of scientific research itself. Further, agentic LLMs may provide a solution for the problem of LLMs running out of training data: inference-time behavior generates new training states, such that LLMs can keep learning without needing ever larger datasets. We note that there is risk associated with LLM assistants taking action in the real world, while agentic LLMs are also likely to benefit society.

Out-of-Distribution (OOD) detection is a critical task in machine learning, particularly in safety-sensitive applications where model failures can have serious consequences. However, current OOD detection methods often suffer from restrictive distributional assumptions, limited scalability, and a lack of interpretability. To address these challenges, we propose STOOD-X, a two-stage methodology that combines a Statistical nonparametric Test for OOD Detection with eXplainability enhancements. In the first stage, STOOD-X uses feature-space distances and a Wilcoxon-Mann-Whitney test to identify OOD samples without assuming a specific feature distribution. In the second stage, it generates user-friendly, concept-based visual explanations that reveal the features driving each decision, aligning with the BLUE XAI paradigm. Through extensive experiments on benchmark datasets and multiple architectures, STOOD-X achieves competitive performance against state-of-the-art post hoc OOD detectors, particularly in high-dimensional and complex settings. In addition, its explainability framework enables human oversight, bias detection, and model debugging, fostering trust and collaboration between humans and AI systems. The STOOD-X methodology therefore offers a robust, explainable, and scalable solution for real-world OOD detection tasks.

Starting in February 2024, the HKUST Library further extended the scope of AI literacy to AI utilization, which focuses on fostering student involvement in utilizing state-of-the-art technologies in the projects that initiated by the Library, named "Digital Scholarship (DS) CoLab". A key focus of the DS CoLab scheme has been on cultivating talents and enabling students to utilize advanced technologies in practical context. It aims to reinforce the library's role as a catalyst and hub for fostering multidisciplinary collaboration and cultivate the "can do spirit" among university members. The Library offers 1-2 projects per year for students to engage with advanced technologies in practical contexts while supporting the Library in tackling challenges and streamlining operational tasks. The tool that introduced in this paper was mainly developed by two of the authors, Sherry Yip Sau Lai and Berry Han Liuruo, as part-time student helpers under one of our DS CoLab scheme in the 2024 Spring Semester (February to May 2024). This paper details the complete journey from ideation to implementation of developing a Chinese Named-Entity Recognition (NER) Tool from the group up within one semester, from the initial research and planning stages to execution and come up a viable product. The collaborative spirit fostered by this project, with students playing a central role, exemplifies the power and potential of innovative educational models that prioritize hands-on learning with student involvement.

Recent advancements in reasoning optimization have greatly enhanced the performance of large language models (LLMs). However, existing work fails to address the complexities of audio-visual scenarios, underscoring the need for further research. In this paper, we introduce AURELIA, a novel actor-critic based audio-visual (AV) reasoning framework that distills structured, step-by-step reasoning into AVLLMs at test time, improving their ability to process complex multi-modal inputs without additional training or fine-tuning. To further advance AVLLM reasoning skills, we present AVReasonBench, a challenging benchmark comprising 4500 audio-visual questions, each paired with detailed step-by-step reasoning. Our benchmark spans six distinct tasks, including AV-GeoIQ, which evaluates AV reasoning combined with geographical and cultural knowledge. Evaluating 18 AVLLMs on AVReasonBench reveals significant limitations in their multi-modal reasoning capabilities. Using AURELIA, we achieve up to a 100% relative improvement, demonstrating its effectiveness. This performance gain highlights the potential of reasoning-enhanced data generation for advancing AVLLMs in real-world applications. Our code and data will be publicly released at: https: //github.com/schowdhury671/aurelia.

Extracting medical history entities (MHEs) related to a patient's chief complaint (CC), history of present illness (HPI), and past, family, and social history (PFSH) helps structure free-text clinical notes into standardized EHRs, streamlining downstream tasks like continuity of care, medical coding, and quality metrics. Fine-tuned clinical large language models (cLLMs) can assist in this process while ensuring the protection of sensitive data via on-premises deployment. This study evaluates the performance of cLLMs in recognizing CC/HPI/PFSH-related MHEs and examines how note characteristics impact model accuracy. We annotated 1,449 MHEs across 61 outpatient-related clinical notes from the MTSamples repository. To recognize these entities, we fine-tuned seven state-of-the-art cLLMs. Additionally, we assessed the models' performance when enhanced by integrating, problems, tests, treatments, and other basic medical entities (BMEs). We compared the performance of these models against GPT-4o in a zero-shot setting. To further understand the textual characteristics affecting model accuracy, we conducted an error analysis focused on note length, entity length, and segmentation. The cLLMs showed potential in reducing the time required for extracting MHEs by over 20%. However, detecting many types of MHEs remained challenging due to their polysemous nature and the frequent involvement of non-medical vocabulary. Fine-tuned GatorTron and GatorTronS, two of the most extensively trained cLLMs, demonstrated the highest performance. Integrating pre-identified BME information improved model performance for certain entities. Regarding the impact of textual characteristics on model performance, we found that longer entities were harder to identify, note length did not correlate with a higher error rate, and well-organized segments with headings are beneficial for the extraction.

Electronic Health Records (EHR) have become a valuable resource for a wide range of predictive tasks in healthcare. However, existing approaches have largely focused on inter-visit event predictions, overlooking the importance of intra-visit nowcasting, which provides prompt clinical insights during an ongoing patient visit. To address this gap, we introduce the task of laboratory measurement prediction within a hospital visit. We study the laboratory data that, however, remained underexplored in previous work. We propose TRACE, a Transformer-based model designed for clinical event nowcasting by encoding patient trajectories. TRACE effectively handles long sequences and captures temporal dependencies through a novel timestamp embedding that integrates decay properties and periodic patterns of data. Additionally, we introduce a smoothed mask for denoising, improving the robustness of the model. Experiments on two large-scale electronic health record datasets demonstrate that the proposed model significantly outperforms previous methods, highlighting its potential for improving patient care through more accurate laboratory measurement nowcasting. The code is available at https://github.com/Amehi/TRACE.

Large Reasoning Models (LRMs) significantly improve the reasoning ability of Large Language Models (LLMs) by learning to reason, exhibiting promising performance in complex task-solving. However, their deliberative reasoning process leads to inefficiencies in token usage, memory consumption, and inference time. Thus, this survey provides a review of efficient inference methods designed specifically for LRMs, focusing on mitigating token inefficiency while preserving the reasoning quality. First, we introduce a taxonomy to group the recent methods into two main categories: (a) explicit compact Chain-of-Thought (CoT), which reduces tokens while keeping the explicit reasoning structure, and (b) implicit latent CoT, which encodes reasoning steps within hidden representations instead of explicit tokens. Meanwhile, we discuss their strengths and weaknesses. Then, we conduct empirical analyses on existing methods from performance and efficiency aspects. Besides, we present open challenges in this field, including human-centric controllable reasoning, trade-off between interpretability and efficiency of reasoning, ensuring safety of efficient reasoning, and broader applications of efficient reasoning. In addition, we highlight key insights for enhancing LRMs' inference efficiency via techniques such as model merging, new architectures, and agent routers. We hope this work serves as a valuable guide, helping researchers overcome challenges in this vibrant field\footnote{https://github.com/yueliu1999/Awesome-Efficient-Inference-for-LRMs}.