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Researchers at Uppsala University have used computer modeling to study how brain tumors arise. Instead of almost exclusively using different biological models, like cells, today large-scale statistical analyses are increasingly used to understand tumor diseases and find new therapies. In the study the researchers used aSICS to interpret data from brain tumors and they could identify a new mechanism behind mesenchymal glioblastoma, an extra aggressive brain tumor type. "According to the computer model, mesenchymal glioblastoma is partly caused by alterations in a gene called Annexin A2.