Check your subscription status, update your details and more. Drug development must change too. In this New Scientist CoLab podcast, experts from global life sciences leader Cytiva explain the hidden, high-stakes science of purification that is required to close the gap between drug discovery and the pharmacy shelf. Artificial intelligence and big data are flooding discovery pipelines with high-potential drug candidates, but this rapid innovation has created a new challenge. Simply put, our capability to design miracle molecules is vastly outstripping our technology to mass-manufacture them safely for the global public.

Check your subscription status, update your details and more. Can you guess the origin of 7 tiny species on a fictional archipelago? Late last year, between one news event and another (honestly, who can remember?), Feedback was delighted to discover the Journal of Imaginary Research . This is an online magazine publishing "short works of fiction", but only if they take the form of "imaginary research abstracts".

Check your subscription status, update your details and more. The controversial idea that consciousness has a quantum origin is facing a new challenge, after a mathematical analysis appears to show that a long-known law of physics makes it impossible. What physical process makes us conscious, and whether we could observe and analyse it, is one of the great open questions of modern science. In the 1990s, mathematician Roger Penrose and anesthesiologist Stuart Hameroff proposed that classical physics can't explain consciousness alone and so it must arise in the quantum realm. The idea was received with scepticism and remains controversial, but attempts to bring quantumness into explanations of consciousness have persisted since.

Check your subscription status, update your details and more. Powerful artificial intelligence models built by Chinese companies have gone from inducing widespread panic to being met with a shrug of the shoulders - what changed? When Chinese company DeepSeek released its open-source R1 model in January 2025, it made headlines around the world. The large language model (LLM) was reported to rival some of the most powerful AIs from US companies, but it was completely free for anyone to download. A trillion dollars was wiped off the value of US tech companies and US lawmakers immediately proposed banning it on government devices.

Mathematicians put AI to work on Fermat's last theorem At an event in London, mathematicians have made unexpectedly fast progress on formalising Fermat's last theorem using AI In the lobby of a central London hotel, tourists are bracing themselves for a day of sightseeing in a heatwave. Meanwhile, staff are resetting the dining room after breakfast. And in a windowless meeting room, assembled academics are contemplating whether humans have a role to play in the future of mathematics, now that AI can prove theorems by itself. The general mood in the room is one of bewilderment at the recent jump in computer intelligence and excitement about the potential it unlocks - and perhaps a slight unease about what the future holds for them personally. Twenty-five researchers from diverse fields and countries are here to spend a week working on formalising Fermat's last theorem with cutting-edge AI models.

From AI with Hannah Fry to David Attenborough's early days, these are the five must-watch science documentaries of the year to date, says Bethan Ackerley In 2015, an amateur trophy hunter from the US shot and killed the largest lion in Africa. The vitriol unleashed after Cecil's death isn't surprising (or entirely unwarranted), but what is remarkable is how this delicately-crafted film uses the case as a locus for all sorts of arguments about conservation. A symbol in life and in death, Cecil and other large, charismatic animals exist in a complex balance with humans who, one way or another, invariably stake a claim on them. Almost everyone in the world now needs to have some knowledge of how AI technologies work, from all the chatbots they encounter to driverless cars and more. Mathematician Hannah Fry is an excellent person to impart such knowledge: across three episodes, she guides us through recent cases where AI has become entangled with very human problems.

Occam's razor has lost its edge. Can we sharpen our search for truth? Seeking out the simplest, most elegant explanations has served scientists well for centuries, but cognitive scientist Marina Dubova's experiments are revealing better ways to uncover reality Limited by the knowledge of his time, the ancient Greek astronomer Ptolemy imagined that the planets and sun of our solar system orbited Earth. Every new observation that pushed against this image required a slight tweak to that theory, until centuries later Nicolaus Copernicus's reimagining toppled it once and for all. A more elegant explanation proposed that all the planets orbited the sun, kicking off a scientific revolution that changed our understanding of the entire universe.

Peter Shor's algorithm could break the internet - but he's not worried Few people have invented an algorithm with the potential to spark a worldwide crisis, so why is quantum computing pioneer Peter Shor so unconcerned? "So, he's the Beyoncé of this event?" a young woman standing behind me says to a colleague. The three of us are standing, looking at the back of a crowd, whose members are all looking at a bearded man in an orange sweater. Getting a look at him is like trying to see the - only fleeting glimpses are possible. "His algorithm is the algorithm that will break everything," the colleague says, as I briefly catch sight of people posing for selfies and getting their conference badges signed.

Does time come from the entire universe running computations? Explaining the passage of time has been a gnarly problem in physics basically forever, but physicist and computer scientist Stephen Wolfram has a radical proposal for where it comes from. What if the universe is just one big computer? My colleagues and I have a running joke: time isn't real. Oh, you thought that deadline was tomorrow, but it's actually today?

Bees seem to show when they are pleased and like something, rather than just needing it, in one of the strongest signs yet that insects have subjective experiences. In recent decades, it has become clear that bees are capable of more complex behaviours than we previously thought, such as counting and demonstrating a sense of rhythm . But discerning whether they have inner states akin to our emotions is more difficult. For one thing, insects don't have the flexible facial musculature of mammals, which we use to communicate our feelings. "How can we get any behavioural readout of these insects with a hard body and their mask of a face," asks Andrew Barron at Macquarie University in Sydney, Australia.