Collaborating Authors

Crowdsourcing a Comprehensive Clinical Trial Repository

AAAI Conferences

We present the open problem of building a comprehensive clinical trial repository to remove duplication of effort from the systematic review process. Arguing that no single organization has the resources to solve this problem, an approach based on crowdsourcing supplemented by automated data extraction appears to be the most promising. To determine the feasibility of this idea, we discuss the key challenges that need to be addressed.

New Federal Rules Aim for Clinical Trial Transparency

U.S. News

To safeguard volunteers' privacy, no individual information will be displayed, only data drawn from the entire study population or for certain defined groups. Researchers must report how they'll carry out the study and analyze the data, and must provide the demographics and health status of study participants, along with data on any side effects that occur – even mild ones – if they strike more than 5 percent of volunteers. Finally, all deaths from any cause must be reported, with breakdowns for each group being studied.

Landmark HIV Vaccine Approaches Clinical Trial

U.S. News

The vaccine uses cytomegalovirus, a common strain of herpes that infects up to 80 percent of Americans, to act as a sort of carrier of the HIV virus. Cytomegalovirus naturally puts T cells – the cells HIV attacks and kills – on alert, so introducing strains of cytomegalovirus into the body that have been engineered to look like HIV will train the body to attack HIV, Oregon Live reports.

Girl's 'miracle' treatment

FOX News

A South Carolina family who were under a self-imposed quarantine for two years to protect their 6-year-old daughter who has a rare, debilitating disease, is celebrating the beginning of a clinical trial that will allow them to return to the outside world. Eliza O'Neill of Columbia, South Carolina, was diagnosed with Sanfilippo syndrome when she was 3 years old, PEOPLE reported. The genetic disorder prevents the body from properly breaking down sugar and causes brain damage, blindness, nerve damage and death. The family, which includes dad Glenn, mom Cara and 9-year-old brother Beckham, set out to raise 2.5 million through their Cure Sanfilippo Foundation page in order to enroll Eliza in a clinical trial that could stop the disorder from regressing further. The trial does not offer a cure, but could prevent her from dying in her teens.