Herpes viruses in the brain linked to Alzheimer's disease

New Scientist

The most in-depth analysis of human brain tissue ever done in Alzheimer's disease has found evidence for the controversial theory that viruses play a role in the condition. If true, it could mean that some instances of Alzheimer's might be treated with anti-viral drugs. Alzheimer's is the most common cause of dementia, affecting some 47 million people worldwide.


A Framework for Individualizing Predictions of Disease Trajectories by Exploiting Multi-Resolution Structure

Neural Information Processing Systems

For many complex diseases, there is a wide variety of ways in which an individual can manifest the disease. The challenge of personalized medicine is to develop tools that can accurately predict the trajectory of an individual's disease, which can in turn enable clinicians to optimize treatments. We represent an individual's disease trajectory as a continuous-valued continuous-time function describing the severity of the disease over time. We propose a hierarchical latent variable model that individualizes predictions of disease trajectories. This model shares statistical strength across observations at different resolutions--the population, subpopulation and the individual level. We describe an algorithm for learning population and subpopulation parameters offline, and an online procedure for dynamically learning individual-specific parameters. Finally, we validate our model on the task of predicting the course of interstitial lung disease, a leading cause of death among patients with the autoimmune disease scleroderma. We compare our approach against state-of-the-art and demonstrate significant improvements in predictive accuracy.


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#artificialintelligence

Out of the total number, 48 were scans of people with the disease, while 48 were scans of people who suffered from mild cognitive impairment and eventually developed full-blown Alzheimer's. The AI was able to diagnose Alzheimer's 86 percent of the time. More importantly, it was able to detect mild cognitive impairment 84 percent of the time, making it a potentially effective tool for early diagnosis. With more samples and further development, though, the AI could become more accurate until it's reliable enough to be used as a non-invasive early detection system.


Alzheimer's Or NPH: Both Can Steal Your Identity, But You Can Come Back From One

Forbes - Tech

There are some things one can only achieve by a deliberate leap in the opposite direction. The first time it happened was in 1999. I was fast asleep when the phone next to my bed rang. Mom said one side of dad's face was drooping and he was confused. My dad didn't get confused.


People diagnosed with Alzheimer's share the memories they don't want to forget

Mashable

Cut Video asked six people, ages 51 to 70, recently diagnosed with Alzheimer's about some of their memories. Alzheimer's is a type of dementia that affects the memory, so of the many questions Cut Video asked, perhaps the most heartbreaking was what things the participants didn't ever want to forget. While each person answered differently, there was one common theme throughout: family. Watch comedian Marina Franklin's most hilarious stranded moments Conan O'Brien on Orlando shooting: 'Weapons of war have no place in civilian life' New'Pete's Dragon' trailer is packed with perfectly nostalgic whimsy