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Artificial intelligence reveals current drugs that may help combat Alzheimer's disease

#artificialintelligence

Independent validation of the nominated drug targets could provide new insights into the mechanisms behind Alzheimer's disease and lead to novel therapies. BOSTON – New treatments for Alzheimer's disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence–based method to screen currently available medications as possible treatments for Alzheimer's disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action.


AI reveals current drugs that may help combat Alzheimer's disease

#artificialintelligence

New treatments for Alzheimer's disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence based method to screen currently available medications as possible treatments for Alzheimer's disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action. "Repurposing FDA-approved drugs for Alzheimer's disease is an attractive idea that can help accelerate the arrival of effective treatment - but unfortunately, even for previously approved drugs, clinical trials require substantial resources, making it impossible to evaluate every drug in patients with Alzheimer's disease," explains Artem Sokolov, PhD, director of Informatics and Modeling at the Laboratory of Systems Pharmacology at HMS. "We therefore built a framework for prioritizing drugs, helping clinical studies to focus on the most promising ones."


Artificial intelligence reveals current drugs that may help combat Alzheimer's disease

#artificialintelligence

New treatments for Alzheimer's disease are desperately needed, but numerous clinical trials of investigational drugs have failed to generate promising options. Now a team at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS) has developed an artificial intelligence-based method to screen currently available medications as possible treatments for Alzheimer's disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action. "Repurposing FDA-approved drugs for Alzheimer's disease is an attractive idea that can help accelerate the arrival of effective treatment--but unfortunately, even for previously approved drugs, clinical trials require substantial resources, making it impossible to evaluate every drug in patients with Alzheimer's disease," explains Artem Sokolov, Ph.D., director of Informatics and Modeling at the Laboratory of Systems Pharmacology at HMS. "We therefore built a framework for prioritizing drugs, helping clinical studies to focus on the most promising ones."


AI-based method used to screen for Alzheimer's disease drugs

#artificialintelligence

Researchers have used artificial intelligence to screen 80 FDA-approved drugs and reveal which could be used as Alzheimer's treatments. A team at Massachusetts General Hospital (MGH) and Harvard Medical School (HMS), both US, has developed an artificial intelligence (AI)-based method to screen currently available medications as possible treatments for Alzheimer's disease. According to the researchers, the method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for the neurodegenerative condition. It could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action. "Repurposing US Food and Drug Administration (FDA)-approved drugs for Alzheimer's disease is an attractive idea that can help accelerate the arrival of effective treatment – but unfortunately, even for previously approved drugs, clinical trials require substantial resources, making it impossible to evaluate every drug in patients with Alzheimer's disease," explained Dr Artem Sokolov, at HMS. "We therefore built a framework for prioritising drugs, helping clinical studies to focus on the most promising ones."


AI reveals current drugs that may help combat Alzheimer's

#artificialintelligence

New York, March 7 (IANS) Researchers have developed a method based on Artificial Intelligence (AI) that rapidly identifies currently available medications that may treat Alzheimer's disease. The method could represent a rapid and inexpensive way to repurpose existing therapies into new treatments for this progressive, debilitating neurodegenerative condition. Importantly, it could also help reveal new, unexplored targets for therapy by pointing to mechanisms of drug action. "Repurposing FDA-approved drugs for Alzheimer's disease is an attractive idea that can help accelerate the arrival of effective treatment -- but unfortunately, even for previously approved drugs, clinical trials require substantial resources, making it impossible to evaluate every drug in patients with Alzheimer's disease," said researcher Artem Sokolov from Harvard Medical School. "We therefore built a framework for prioritising drugs, helping clinical studies to focus on the most promising ones," Sokolov added.