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Artificial Intelligence Model Identifies 'Amazing' Antibiotic Candidate

#artificialintelligence

Researchers at Massachusetts Institute of Technology (MIT) have harnessed a machine-learning algorithm to identify a new antibiotic compound that, in laboratory tests, killed many of the world's most challenging disease-causing bacteria, including some strains that are resistant to all known antibiotics. The new antibiotic candidate, which has been given the name halicin--after the fictional artificial intelligence system from "2001: A Space Odyssey,"--was discovered in the Drug Repurposing Hub, and is structurally different to conventional antibiotics. Initial in vivo experiments showed that halicin was effective against Clostridium difficile and pan-resistant Acinetobacter baumannii infections in two mouse models. "We wanted to develop a platform that would allow us to harness the power of artificial intelligence to usher in a new age of antibiotic drug discovery," said James Collins, PhD, the Termeer professor of medical engineering and science in MIT's Institute for Medical Engineering and Science (IMES) and department of biological engineering. "Our approach revealed this amazing molecule which is arguably one of the more powerful antibiotics that has been discovered."


MIT Uses Artificial Intelligence to Identify Powerful New Antibiotic

#artificialintelligence

MIT researchers have identified a powerful new antibiotic compound using a machine-learning algorithm. A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria. Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models.


Artificial intelligence yields new antibiotic

#artificialintelligence

Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models. The computer model, which can screen more than a hundred million chemical compounds in a matter of days, is designed to pick out potential antibiotics that kill bacteria using different mechanisms than those of existing drugs. "We wanted to develop a platform that would allow us to harness the power of artificial intelligence to usher in a new age of antibiotic drug discovery," says James Collins, the Termeer Professor of Medical Engineering and Science in MIT's Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering.


Artificial intelligence yields new antibiotic

#artificialintelligence

Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models. The computer model, which can screen more than a hundred million chemical compounds in a matter of days, is designed to pick out potential antibiotics that kill bacteria using different mechanisms than those of existing drugs. "We wanted to develop a platform that would allow us to harness the power of artificial intelligence to usher in a new age of antibiotic drug discovery," says James Collins, the Termeer Professor of Medical Engineering and Science in MIT's Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering.


Artificial intelligence yields new antibiotic: A deep-learning model identifies a powerful new drug that can kill many species of antibiotic-resistant bacteria

#artificialintelligence

The computer model, which can screen more than a hundred million chemical compounds in a matter of days, is designed to pick out potential antibiotics that kill bacteria using different mechanisms than those of existing drugs. "We wanted to develop a platform that would allow us to harness the power of artificial intelligence to usher in a new age of antibiotic drug discovery," says James Collins, the Termeer Professor of Medical Engineering and Science in MIT's Institute for Medical Engineering and Science (IMES) and Department of Biological Engineering. "Our approach revealed this amazing molecule which is arguably one of the more powerful antibiotics that has been discovered." In their new study, the researchers also identified several other promising antibiotic candidates, which they plan to test further. They believe the model could also be used to design new drugs, based on what it has learned about chemical structures that enable drugs to kill bacteria.