Fruehwirt, Wolfgang, Cobb, Adam D., Mairhofer, Martin, Weydemann, Leonard, Garn, Heinrich, Schmidt, Reinhold, Benke, Thomas, Dal-Bianco, Peter, Ransmayr, Gerhard, Waser, Markus, Grossegger, Dieter, Zhang, Pengfei, Dorffner, Georg, Roberts, Stephen
As societies around the world are ageing, the number of Alzheimer's disease (AD) patients is rapidly increasing. To date, no low-cost, non-invasive biomarkers have been established to advance the objectivization of AD diagnosis and progression assessment. Here, we utilize Bayesian neural networks to develop a multivariate predictor for AD severity using a wide range of quantitative EEG (QEEG) markers. The Bayesian treatment of neural networks both automatically controls model complexity and provides a predictive distribution over the target function, giving uncertainty bounds for our regression task. It is therefore well suited to clinical neuroscience, where data sets are typically sparse and practitioners require a precise assessment of the predictive uncertainty. We use data of one of the largest prospective AD EEG trials ever conducted to demonstrate the potential of Bayesian deep learning in this domain, while comparing two distinct Bayesian neural network approaches, i.e., Monte Carlo dropout and Hamiltonian Monte Carlo.
We trained and evaluated a localization-based deep CNN for breast cancer screening exam classification on over 200,000 exams (over 1,000,000 images). Our model achieves an AUC of 0.919 in predicting malignancy in patients undergoing breast cancer screening, reducing the error rate of the baseline (Wu et al., 2019a) by 23%. In addition, the models generates bounding boxes for benign and malignant findings, providing interpretable predictions.
Babak Ehteshami Bejnordi, from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues compared the performance of automated deep learning algorithms for detecting metastases in hematoxylin and eosin-stained tissue sections of lymph nodes of women with breast cancer with pathologists' diagnoses in a diagnostic setting. The researchers found that the area under the receiver operating characteristic curve (AUC) ranged from 0.556 to 0.994 for the algorithms. The lesion-level, true-positive fraction achieved for the top-performing algorithm was comparable to that of the pathologist without a time constraint at a mean of 0.0125 false-positives per normal whole-slide image. Daniel Shu Wei Ting, M.D., Ph.D., from the Singapore National Eye Center, and colleagues assessed the performance of a DLS for detecting referable diabetic retinopathy and related eye diseases using 494,661 retinal images. The researchers found that the AUC of the DLS for referable diabetic retinopathy was 0.936, and sensitivity and specificity were 90.5 and 91.6 percent, respectively.
In this paper, we present an experimental study for the classification of perceived human stress using non-invasive physiological signals. These include electroencephalography (EEG), galvanic skin response (GSR), and photoplethysmography (PPG). We conducted experiments consisting of steps including data acquisition, feature extraction, and perceived human stress classification. The physiological data of $28$ participants are acquired in an open eye condition for a duration of three minutes. Four different features are extracted in time domain from EEG, GSR and PPG signals and classification is performed using multiple classifiers including support vector machine, the Naive Bayes, and multi-layer perceptron (MLP). The best classification accuracy of 75% is achieved by using MLP classifier. Our experimental results have shown that our proposed scheme outperforms existing perceived stress classification methods, where no stress inducers are used.
A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online December 12 in the Journal of the American Medical Association.