A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online Dec. 12 in the Journal of the American Medical Association.
A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online December 12 in the Journal of the American Medical Association.
Interpretability is a key factor in the design of automatic classifiers for medical diagnosis. Deep learning models have been proven to be a very effective classification algorithm when trained in a supervised way with enough data. The main concern is the difficulty of inferring rationale interpretations from them. Different attempts have been done in last years in order to convert deep learning classifiers from high confidence statistical black box machines into self-explanatory models. In this paper we go forward into the generation of explanations by identifying the independent causes that use a deep learning model for classifying an image into a certain class. We use a combination of Independent Component Analysis with a Score Visualization technique. In this paper we study the medical problem of classifying an eye fundus image into 5 levels of Diabetic Retinopathy. We conclude that only 3 independent components are enough for the differentiation and correct classification between the 5 disease standard classes. We propose a method for visualizing them and detecting lesions from the generated visual maps.
In this work, we provide a new formulation for Graph Convolutional Neural Networks (GCNNs) for link prediction on graph data that addresses common challenges for biomedical knowledge graphs (KGs). We introduce a regularized attention mechanism to GCNNs that not only improves performance on clean datasets, but also favorably accommodates noise in KGs, a pervasive issue in real-world applications. Further, we explore new visualization methods for interpretable modelling and to illustrate how the learned representation can be exploited to automate dataset denoising. The results are demonstrated on a synthetic dataset, the common benchmark dataset FB15k-237, and a large biomedical knowledge graph derived from a combination of noisy and clean data sources. Using these improvements, we visualize a learned model's representation of the disease cystic fibrosis and demonstrate how to interrogate a neural network to show the potential of PPARG as a candidate therapeutic target for rheumatoid arthritis.