Accuracy of a Deep Learning Algorithm for Detection of Diabetic Retinopathy

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Question How does the performance of an automated deep learning algorithm compare with manual grading by ophthalmologists for identifying diabetic retinopathy in retinal fundus photographs? Finding In 2 validation sets of 9963 images and 1748 images, at the operating point selected for high specificity, the algorithm had 90.3% and 87.0% sensitivity and 98.1% and 98.5% specificity for detecting referable diabetic retinopathy, defined as moderate or worse diabetic retinopathy or referable macular edema by the majority decision of a panel of at least 7 US board-certified ophthalmologists. At the operating point selected for high sensitivity, the algorithm had 97.5% and 96.1% sensitivity and 93.4% and 93.9% specificity in the 2 validation sets. Meaning Deep learning algorithms had high sensitivity and specificity for detecting diabetic retinopathy and macular edema in retinal fundus photographs. Importance Deep learning is a family of computational methods that allow an algorithm to program itself by learning from a large set of examples that demonstrate the desired behavior, removing the need to specify rules explicitly. Application of these methods to medical imaging requires further assessment and validation. Objective To apply deep learning to create an algorithm for automated detection of diabetic retinopathy and diabetic macular edema in retinal fundus photographs. Design and Setting A specific type of neural network optimized for image classification called a deep convolutional neural network was trained using a retrospective development data set of 128 175 retinal images, which were graded 3 to 7 times for diabetic retinopathy, diabetic macular edema, and image gradability by a panel of 54 US licensed ophthalmologists and ophthalmology senior residents between May and December 2015.


EyeArt Screening System Detects Diabetic Retinopathy

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Data on the effectiveness of the artificial intelligence screening system EyeArt was presented at the American Academy of Ophthalmology (AAO) 2019 Annual Meeting in San Francisco. Results of the study examining EyeArt revealed the system had the ability to accurately predict diabetic retinopathy 95.5% of the time, without the input of an ophthalmologist, and in less than a minute. With the diabetes epidemic continuing to plague patient populations in the US and across the globe--and 1 in 4 diabetics developing diabetic retinopathy--investigators sought to evaluate the effectiveness of the artificial intelligence screening system in a group of 893 patients. Led by Srinivas Sadda, MD, of the Doheny Eye Institute at UCLA, investigators conducted the study at 15 different centers across the US. For inclusion in the study, patients needed to have a diagnosis pf diabetes mellitus, be at least 18 years of age, and provide written informed consent.


Google working with Aravind Eye Hospital to train its AI in diabetic retinopathy screening FactorDaily

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India's largest eye care provider, Aravind Eye Hospital, has been quietly working for over four years with Google on a project to use artificial intelligence (AI) in ophthalmology. Aravind Eye Hospital, which has branches across India, is headquartered in Madurai, Tamil Nadu. Lily Peng, product manager at Google, who released a paper on the research a year ago, said at the 2017 WIRED Business Conference that Google had just finished a clinical study in India, and that work was underway to get the technology into routine use with patients. India, considered the diabetes capital of the world, has over 70 million diabetes patients who are at risk of blindness due to the disease. India's largest eye care provider, Aravind Eye Hospital, has been quietly working for over three to four years with Google on a project to use artificial intelligence in ophthalmology At the TensorFlow Dev Summit earlier this year, Peng had said that that Google's machine learning algorithm was very close to an ophthalmologist in terms of performance.


Study examines use of deep machine learning for detection of diabetic retinopathy

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In an evaluation of retinal photographs from adults with diabetes, an algorithm based on deep machine learning had high sensitivity and specificity for detecting referable diabetic retinopathy, according to a study published online by JAMA. Among individuals with diabetes, the prevalence of diabetic retinopathy is approximately 29 percent in the United States. Most guidelines recommend annual screening for those with no retinopathy or mild diabetic retinopathy and repeat examination in 6 months for moderate diabetic retinopathy. Retinal photography with manual interpretation is a widely accepted screening tool for diabetic retinopathy. Automated grading of diabetic retinopathy has potential benefits such as increasing efficiency and coverage of screening programs; reducing barriers to access; and improving patient outcomes by providing early detection and treatment.


This AI screening tool for diabetic retinopathy makes a decision, not a recommendation - MedCity News

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Artificial intelligence is a healthcare and technology buzzword right now, but IDx Founder and President Michael Abràmoff is not a Johnny-come-lately to this phenomenon. His journey and that of the company's lead product began over two decades ago in the Netherlands.