Home care agencies might want to think twice about how they handle workers who are chronically late to client visits. "When we started Honor, we thought, clearly, if a care pro is late, that's terrible," Seth Sternberg, CEO of the San Francisco-based company, told Home Health Care News. "And then we learned that's not true." That counterintuitive lesson about late workers came from analyzing data gathered through Honor's proprietary technology platform. About three years after launching, Honor now is looking closely at its data and adjusting operations accordingly, in a variety of ways.
Josef von Sternberg was not only one of the great directors of the 1920s and '30s, he was also an art collector in the circle of the enterprising dealer Galka Scheyer. She's the subject of the current "The Maven of Modernism" exhibit at the Norton Simon in Pasadena, and that enterprising museum is showing some of Von Sternberg's films along with it. Closing the series is 1932's "Shanghai Express," a stunning black-and-white extravaganza starring Von Sternberg's muse Marlene Dietrich as the enigmatic Shanghai Lily. "It took more than one man," she states enigmatically, "to change my name to Shanghai Lily."
CRISPR genome editing technology is revolutionising biology, but it could soon become even powerful. Two teams have developed new variants of the method based on "jumping genes" that might make it much easier to add pieces of DNA to cells. "I think we will see a flurry of excitement around this," says Samuel Sternberg of Columbia University in New York, who leads one of the teams. For everything from treating many genetic diseases to creating genetically modified organisms, adding DNA to the genomes of cells is a key step. But none of the existing methods work particularly well.
For years, scientists have used a tool something like a pair of scissors for the complex task of gene-editing, but a newly discovered technique using "jumping genes" could offer a seamless, safer alternative. Gene-editing is the process of altering a part of DNA -- the code that governs much about how an organism develops and behaves. A key tool for editing is the CRISPR-Cas9 process, which uses CRISPRs -- a part of the immune defense system in bacteria -- to locate a target in the DNA, and the protein Cas9 to "snip" the DNA strand. The DNA then repairs itself, sometimes guided by a template that is inserted during the editing process. But the process is not always effective -- sometimes the repairs are incomplete or incorrect, and the damage response prompted by the cutting can have negative side effects.
The rise of the great movie stars is almost always a story of collaboration with great directors. The film career of Marlene Dietrich burst into enduring prominence in 1930, with Josef von Sternberg's "The Blue Angel," and they made six more films together, including "Dishonored" (which I discuss in this clip), from 1931, in which Dietrich's onscreen persona became refined to a degree of breathtaking precision, and expanded to a historical--even a philosophical--scope. "Dishonored," set during the First World War, is a story of danger and death; it's a war film in which the crucial battles are psychological ones that are fought in back rooms. Dietrich plays a spy, or, rather, a prostitute who becomes a spy--Agent X-27, to be specific; she boldly and slyly uses her powers of seduction to expose enemy spies and extract their secrets. It's also a sort of musical, in which Dietrich deploys the music-hall artistry that's essential to "The Blue Angel" and gives it a deliriously political angle. Sternberg, who was himself something of a directorial newcomer--he had made his first film in 1925, but he also had a rapid rise in the studio system, making some of the most notable films of the late silent era, including the gangster film "Underworld," which set the template for the genre, and the giddy drama "The Last Command," which blends an inside-Hollywood story with a Russian Revolution narrative.