He collaborated with the professional songwriters and came up with Fight For Me during the annual Frank Brown International Songwriter's Festival in 2015. The large festival, which is more than 30 years old, has venues stretching from Gulf Shores, Alabama, through the Pensacola area. Last year, Chandler and fellow Pensacola veteran Janet Keiser worked with festival songwriters on another song, 22 A Day.
PORTLAND, Ore. – Two members of an Oregon church that shuns traditional medicine in favor of prayer and anointing the sick with oils were arrested Monday in the death of their premature baby. Sarah Mitchell, 24, and Travis Lee Mitchell, 21, are accused of murder and criminal mistreatment. They have been under investigation since March, when Sarah delivered twin girls at her grandparents' home. One of the babies had breathing problems and died a few hours later. The couple are members of the Followers of Christ Church, which embraces faith healing.
Human skin is coated with microorganisms, some of which can cause serious infection when the skin barrier is wounded. Microorganisms on all barrier surfaces are continually monitored by the host's various immune responses. Linehan et al. found that the skin-dwelling organism Staphylococcus epidermidis specifically prompts an ancient arm of the immune system (the major histocompatibility complex class 1b molecule H2-M3) to respond in a way that avoids inflammation--distinct from responses to pathogens. H2-M3 processes and presents S. epidermidis–derived N-formyl methionine peptides to CD8 T cells. These cells express immunoregulatory and tissue-repair gene signatures and accelerate skin wound healing. Hence, hosts and microbiota can interact in highly beneficial ways that may hold promise for therapeutic interventions.
Targeted oral delivery of therapeutics for the treatment of chronic bowel disease might alleviate some of the side effects caused by systemic delivery, but this route requires a means to prevent degradation of the drugs within the gastrointestinal tract. Li et al. devise a multicomponent drug delivery platform built around porous silicon nanoparticles. Surface functionalization with hyaluronic acid gives the particles a negative charge so that they do not adhere to intact mucosa. A hydrogel based on an active pharmaceutical agent and ascorbyl palmitate is loaded into the pores of the particles and releases the drug in the presence of specific enzymes. Furthermore, the entire construct is coated with hydroxypropyl methylcellulose acetate, which can be tuned to be soluble at a specific pH to provide protected delivery to the required location.