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New Way of Defining Alzheimer's Aims to Find Disease Sooner

U.S. News

Another problem: as many as 30 percent of people enrolled in Alzheimer's studies based on symptoms didn't actually have the disease -- they had other forms of dementia or even other medical conditions. That doesn't give an accurate picture of whether a potential treatment might help, and the new definition aims to improve patient selection by using brain scans and other tests.


A unifying concept in vascular health and disease

Science

Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. But is this really the case? An evaluation of the literature suggests that unresolved vascular remodeling may be a key element of virtually all vascular diseases. This commonality raises the possibility of unifying principles that govern vascular remodeling and the possibility that methods to restore normal remodeling could effectively treat multiple disease states.


'They thought he was too young for heart disease'

BBC News

A mother whose son died from heart disease has urged parents to know the signs and trust their instincts if they think their child is seriously ill. Jordan Simon was diagnosed with dilated cardiomyopathy at the age of 16 after several trips to hospital, was given a heart transplant and managed to live his dream of being a holiday park entertainer before his death in November, aged 25. His mum Sarah Tustin, from March in Cambridgeshire, said she did not blame doctors for missed opportunities to diagnose him sooner but that he would have died "within hours" if she had not been persistent. She said: "Because he was young, the doctors couldn't possibly think he had heart disease. If there's parents out there that have got teenagers that are having the same symptoms, breathless, lethargic, do not accept the first diagnosis from the hospital or doctors."


Infographic: Measles: Deadly Disease Makes a Comeback

#artificialintelligence

In 2014, the WHO annual measles update was titled "Measles deaths reach record lows with fragile gains toward global elimination." It's safe to say that these headlines are a thing of the past since the organization had worse news this time around. In 2018, the WHO estimates that 140,000 people died of measles worldwide, the highest number since 2013. In 2000, as many as 562,000 people were dying of the disease. This number was significantly reduced by vaccination programs.


Despite some progress, pharmaceutical firms' Alzheimer's fight falling flat

The Japan Times

PARIS – It's a devastating disease driving a dementia epidemic ruining tens of millions of lives, but with no new medical treatment since the turn of the century the fight against Alzheimer's is foundering. Despite decades of research and hundreds of millions of dollars, the precise cause of the neurodegenerative disease -- which leaves victims suffering from memory loss, disorientation and behavioral problems -- remains poorly understood. "It's a bit like solving a jigsaw puzzle without knowing what the end result needs to look like," said Pierre Tariot, director of the Banner Alzheimer's Institute in Phoenix, Arizona. This year alone, pharmaceutical giants -- including Lundbeck, Takeda, Merck & Co., Janssen Biotech, AstraZeneca and Eli Lilly -- have either halted or failed in their search for a new Alzheimer's drug. U.S. drug giant Pfizer said in January it was abandoning all research into the disease.