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Machine Learning and Artificial Intelligence Advancing Mineral Exploration

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Machine learning and artificial intelligence are becoming key components of mineral exploration programs as companies set exploration targets. Machine learning and artificial intelligence (AI) have the ability to solve two of the mining industry's biggest challenges: rising exploration costs and a lack of new discoveries. After a heavy downturn in the past few years, the mining and mineral exploration sector is finally starting to recover, but deep challenges remain. In an industry that thrives on new discoveries, today's resource companies are finding it harder and more expensive to locate new deposits. Gold provides one of the greatest examples of this dearth of new discoveries in the face of rising exploration costs.


How Can AI Help in the Pharma Industry?

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Expansion in size as well as in medicine datasets is amongst a few factors that have contributed to the development of AI in the pharmaceutical industry. FREMONT, CA: Artificial Intelligence (AI) is considered to be the growing technology that discovers its application in almost every aspect of life and industry. Similarly, the pharmaceutical industry is introducing innovative methods to make use of persuasive techniques to determine the challenges faced by pharma in the present time. Exploring AI in pharma can include three major divisions, which are innovation, growth, and commercialization. It is significant to remember that AI is best suited to perform recurring tasks wherever there is a lack of efficiency.


Discovering and designing drugs with artificial intelligence

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The first drug designed using artificial intelligence (AI) has moved into its Phase I trial. Professor Andrew Hopkins of Exscientia explains how an algorithm was used to achieve this milestone. In a landmark development, the first drug created using artificial intelligence (AI) has moved into its Phase I trial. Named DSP-1181, the compound was created in a joint venture between Exscientia and Sumitomo Dainippon Pharma for the treatment of obsessive-compulsive disorder (OCD). Speaking with Drug Target Review's Victoria Rees, Professor Andrew Hopkins, Chief Executive Officer of Exscientia, explained how the drug was discovered and optimised in only 12 months.


Supercomputers On The Hunt For Middle Molecules

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Called the Program to Industrialize an Innovative Middle Molecule Drug Discovery Flow through Fusion of Computational Drug Design and Chemical Synthesis Technology, the partnership will see both sides jointly conduct R&D and construct infrastructure. Conventional drug discovery mainly consists of synthesizing small molecules with a molecular weight under 500 daltons (Da), a strategy known as small molecule drug discovery. In recent years, drug discovery has turned to large molecules such as antibodies that have therapeutic properties. However, industrial synthesis of large molecules is difficult and poses numerous issues such as the extremely high cost incurred for creation using animal cells under advanced control conditions. On the other hand, middle molecules--peptides, nucleic acids and other molecules with a molecular weight of about 500 to 30,000 Da--can be chemically synthesized and may offer benefits that are similar to large molecules.


The importance of synthetic chemistry in the pharmaceutical industry

Science

Over the past century, innovations in synthetic methods have changed the way scientists think about designing and building molecules, enabling access to more expansive chemical space and to molecules possessing the essential biological activity needed in future investigational drugs. In order for the pharmaceutical industry to continue to produce breakthrough therapies that address global health needs, there remains a critical need for invention of synthetic transformations that can continue to drive new drug discovery. Toward this end, investment in research directed toward synthetic methods innovation, furthering the nexus of synthetic chemistry and biomolecules, and developing new technologies to accelerate methods discovery is essential. One powerful example of an emerging, transformative synthetic method is the recent discovery of photoredox catalysis, which allows one to harness the energy of visible light to accomplish synthetic transformations on drug-like molecules that were previously unachievable. Furthermore, recent breakthroughs in molecular biology, bioinformatics, and protein engineering are driving rapid identification of biocatalysts that possess desirable stability, unique activity, and exquisite selectivity needed to accelerate drug discovery.