Adenosine triphosphate (ATP) has well-characterized roles in providing energy for biochemical reactions within cells. Patel et al. find that ATP may also enhance protein solubility, which could help explain why such high concentrations of ATP are maintained in cells (see the Perspective by Rice and Rosen). Protein concentrations in cells can exceed 100 mg/ml. The authors found that ATP at concentrations found in cells could act as a hydrotrope to help solubilize hydrophobic proteins. The results raise the possibility that ATP concentrations could influence processes such as protein aggregation that occur in disease or liquid-liquid phase separations that occur within cells.
Women who have given birth seem to have hallmarks of faster biological ageing than those that don't – and the difference is equivalent to around 11 years. That's what Anna Pollack and her colleagues at George Mason University, Virginia, found when they looked at one measure of biological ageing. The team looked at the length of telomeres – chunks of DNA that cap the ends of chromosomes.