Another problem: as many as 30 percent of people enrolled in Alzheimer's studies based on symptoms didn't actually have the disease -- they had other forms of dementia or even other medical conditions. That doesn't give an accurate picture of whether a potential treatment might help, and the new definition aims to improve patient selection by using brain scans and other tests.
Although deaths from cardiovascular disease have substantially dropped over the past 35 years in the United States, it is still the country's leading cause of death. But, new research highlights there's large differences in disease mortality rates for certain types of heart problems, depending on where you live. The study, published in JAMA, highlights the cardiovascular disease mortality rates across the country for the past few decades. The researchers found that the mortality rate for cardiovascular diseases decreased from 507 deaths to 253 deaths per 100,000 persons from 1980 to 2014. The researcher's findings are illustrated in the map below, which shows that mortality rates are especially high in some regions of the country and far greater than the national average.
Not unlike Tolstoy's remark about happy versus unhappy families, current wisdom in vascular biology holds that healthy blood vessels are mostly similar, whereas vessels in different vascular diseases are mostly different. But is this really the case? An evaluation of the literature suggests that unresolved vascular remodeling may be a key element of virtually all vascular diseases. This commonality raises the possibility of unifying principles that govern vascular remodeling and the possibility that methods to restore normal remodeling could effectively treat multiple disease states.
In 2014, the WHO annual measles update was titled "Measles deaths reach record lows with fragile gains toward global elimination." It's safe to say that these headlines are a thing of the past since the organization had worse news this time around. In 2018, the WHO estimates that 140,000 people died of measles worldwide, the highest number since 2013. In 2000, as many as 562,000 people were dying of the disease. This number was significantly reduced by vaccination programs.
PARIS – It's a devastating disease driving a dementia epidemic ruining tens of millions of lives, but with no new medical treatment since the turn of the century the fight against Alzheimer's is foundering. Despite decades of research and hundreds of millions of dollars, the precise cause of the neurodegenerative disease -- which leaves victims suffering from memory loss, disorientation and behavioral problems -- remains poorly understood. "It's a bit like solving a jigsaw puzzle without knowing what the end result needs to look like," said Pierre Tariot, director of the Banner Alzheimer's Institute in Phoenix, Arizona. This year alone, pharmaceutical giants -- including Lundbeck, Takeda, Merck & Co., Janssen Biotech, AstraZeneca and Eli Lilly -- have either halted or failed in their search for a new Alzheimer's drug. U.S. drug giant Pfizer said in January it was abandoning all research into the disease.