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Robotic implant could help children with rare disorder eat again

New Scientist

Some children are born with their oesophagus in two segments, so the tube doesn't connect to their stomach. A new robotic implant might help treat this serious condition, known as oesophageal atresia. The robot consists of two steel rings, some sensors and a motor, all sealed in a protective waterproof skin. The device is attached to the outside of one section of the oesophagus and gently elongates it by moving the rings apart. Once the organ is long enough, the two segments can be stitched together.

Middle-aged people have MORE cancer-causing mutant cells than normal ones, shock study reveals

Daily Mail - Science & tech

Middle-aged people have more mutant cells than normal ones, researchers claim. Scientists found up to 80 per cent of cells contain mutations that could cause cancer - even if they seem healthy under a microscope. In their examination of the oesophageal tissue of dead people, they also discovered people in their twenties have a few hundred mutations in some cells. However, this can rise to more than 2,000 as they get older, leading to healthy tissue being'riddled with mutations'. Although not all of these will go on to cause cancer, the researchers hope the study will help experts better understand the disease's onset.

How to Implement a Ticket Triaging System with AI


Customer queries are the bane of most customer support teams, not because they don't like dealing with them, but because they don't have a proper process in place that lets them handle excessive ticket volumes easily and effectively. When a support ticket drops into a queue, or an agent receives an email with a customer issue, the ticket or email might pass through three different agents before finally landing in the correct hands to deal with the issue – leading to bottlenecks and bad customer experiences. Bugs, forgotten passwords, system errors, integration queries… There are so many different issues that agents have to deal with, so that the customer remains happy and the company retains them. And while customer support endeavors to respond to queries as quickly as possible, it's difficult when faced with huge volumes of tickets. On top of that, more and more customers expect immediate responses – 64% of consumers and 80% of business buyers said they expect companies to respond to and interact with them in real time.

[Report] Mechanistic basis for a molecular triage reaction


Newly synthesized proteins are triaged between biosynthesis and degradation to maintain cellular homeostasis, but the decision-making mechanisms are unclear. We reconstituted the core reactions for membrane targeting and ubiquitination of nascent tail-anchored membrane proteins to understand how their fate is determined. The central six-component triage system is divided into an uncommitted client-SGTA complex, a self-sufficient targeting module, and an embedded but self-sufficient quality control module. Client-SGTA engagement of the targeting module induces rapid, private, and committed client transfer to TRC40 for successful biosynthesis. Commitment to ubiquitination is dictated primarily by comparatively slower client dissociation from SGTA and nonprivate capture by the BAG6 subunit of the quality control module.

Very hot drinks 'probably' cause cancer of the oesophagus, world health chiefs warn

Daily Mail - Science & tech

Drinking very hot beverages'probably' causes cancer of the oesophagus, global health experts warned today. Gulping down anything very hot - over 65 C (150F) - including water, coffee, tea and other beverages - is linked to the disease, according The World Health Organisation's cancer agency. The theory is that cancer can be initiated by constant irritation of the lining of the mouth and throat by very hot water. '[New figures] suggest drinking very hot beverages is one probable cause of oesophageal cancer and that it is the temperature, rather than the drinks themselves, that appears to be responsible,' said Christopher Wild, director of the WHO's International Agency for Research on Cancer (IARC). However, it concluded it is safe if consumed at'normal serving temperatures' - i.e. 65 or under.