Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice

Science

During metastasis, malignant cells escape the primary tumor, intravasate lymphatic vessels, and reach draining sentinel lymph nodes before they colonize distant organs via the blood circulation. Although lymph node metastasis in cancer patients correlates with poor prognosis, evidence is lacking as to whether and how tumor cells enter the bloodstream via lymph nodes. To investigate this question, we delivered carcinoma cells into the lymph nodes of mice by microinfusing the cells into afferent lymphatic vessels. We found that tumor cells rapidly infiltrated the lymph node parenchyma, invaded blood vessels, and seeded lung metastases without involvement of the thoracic duct. These results suggest that the lymph node blood vessels can serve as an exit route for systemic dissemination of cancer cells in experimental mouse models.


Multi-scale Neural Networks for Retinal Blood Vessels Segmentation

arXiv.org Machine Learning

Existing supervised approaches didn't make use of the low-level features which are actually effective to this task. And another deficiency is that they didn't consider the relation between pixels, which means effective features are not extracted. In this paper, we proposed a novel convolutional neural network which make sufficient use of low-level features together with high-level features and involves atrous convolution to get multi-scale features which should be considered as effective features. Our model is tested on three standard benchmarks - DRIVE, STARE, and CHASE databases. The results presents that our model significantly outperforms existing approaches in terms of accuracy, sensitivity, specificity, the area under the ROC curve and the highest prediction speed. Our work provides evidence of the power of wide and deep neural networks in retinal blood vessels segmentation task which could be applied on other medical images tasks.


Researchers discover blood vessels in lab-grown mini-brains

Engadget

Growing brains in laboratories was just the start for scientists. By studying the naturally occurring capillaries discovered on the mini-brains, researchers from Brown University say that they will be able to conduct bigger investigations into things like strokes and concussions. After some three days of culturing the mini-brains, the scientists discovered that a majority of the samples had developed on their own. After inspecting the "tangles of spaghetti," the researchers found that said tangles had grown on their own and were comprised of the cells and proteins found in blood vessels, according to Eurekalert. Naturally, there wasn't any blood flowing through them but senior author of the study Diane Hoffman-Kim said she has a few ideas for how to make that happen.


Take a virtual trip inside the brain and watch white cells 'glue' broken ends of blood vessels

Daily Mail - Science & tech

As we get older, blood vessels in our brains start to stiffen and can rupture, in a process called'microbleeding'. This is related to diseases such as Parkinson's and Alzheimer's. Until now it was not known whether the brain could naturally repair itself after such a microbleed but researchers have seen, for the first time, how white blood cells kick in to fix the fault. In a breakthrough video, the cells are seen grabbing the broken ends of a blood vessel and'gluing' them back together after they have been damaged. To recreate what happens during a microbleed in a human brain, Professor Luo and his colleagues shot lasers into the brains of live zebrafish to rupture small blood vessels, to create a split in the tissue and left two broken ends.


Scientists grow 'perfect' human blood vessels in lab in breakthrough for heart disease research

Daily Mail - Science & tech

Scientists have managed to grow'perfect' human blood vessels in the lab for the first time. The breakthrough could have a dramatic effect on research into a host of vascular problems, including diabetes. It will allow researchers to study and test new drugs far more easily. A 3D reconstruction of one of the blood vessel'organoids' the team was able to grow from stem cells. 'Being able to build human blood vessels as organoids from stem cells is a game changer,' said the study's senior author Josef Penninger, director of the Life Sciences Institute at the University of British Columbia.