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Crispr gene tool can cause hundreds of unplanned mutations

Daily Mail - Science & tech

Crispr-Cas9 gene editing technology has been hailed as humanity's route to'designer babies' who are tailored with desirable genetic traits. The technique, which can'cut and paste' small sections of DNA, means the next generation may benefit from powerful gene therapies that can delete or repair flawed genes. It could act as a golden bullet for diseases like cancer, HIV and genetic conditions such as Huntington's disease. But a new study has found that Crispr-Cas9, also known as'Crispr', can introduce hundreds of unintended and potentially harmful mutations into DNA. The finding could put a stop to clinical trials scheduled in the US for next year, as well as those currently underway in China.


Editing Human DNA With CRISPR Technology Causes Tons Of Gene Mutations

International Business Times

Messing with a person's DNA can have hundreds of unexpected consequences, causing genetic mutations that scientists cannot predict, researchers warn. In a new study in the journal Nature Methods, a group describes combing through the DNA of mice that had been modified with the CRISPR-Cas9 gene-editing tool, which allows scientists to remove and replace certain genes in a living thing's DNA. In the two mice, who had been cured of blindness with the treatment, there were about 1,700 small and unpredicted changes throughout their genomes -- affecting single nucleotides, which are the building blocks of DNA -- in places that the gene-editing tool had not been used to modify. There were also more than 100 larger changes found. Read: Does Evolution Favor Autism Genes?


Can AI Help With Personalized Medicine? Here's What To Know

#artificialintelligence

A Chinese genetic scientist recently caused an ethical outcry by claiming to have created the world's first gene-edited babies, using CRISPR to modify their DNA before birth to make them resistant to HIV. The procedure, which is effectively barred in most countries, highlights the far-reaching potential of gene editing and CRISPR as well as the ethical, moral and social implications of going too far. And quite understandably, the incident has reignited the conversation around AI and how gene editing should be regulated. CRISPR is a gene editing technology that can be used to precision target specific DNA sequences to deliberately activate or inhibit genes. Ever since it was introduced six years ago, much of the focus has been on CRISPR's potential to treat genetic diseases and its impact on drug discovery and development.


The Amazing Ways Artificial Intelligence Is Transforming Genomics and Gene Editing

#artificialintelligence

By 2021, consultant firm Frost & Sullivan expects that artificial intelligence (AI) systems will generate $6.7 billion in revenue from healthcare globally. One area that machine learning is significantly evolving is genomics--the study of the complete set of genes within an organism. While much attention has been paid to the implications for human health, genetic sequencing and analysis could also be ground-breaking for agriculture and animal husbandry. When researchers can sequence and analyze DNA, something that artificial intelligence systems make faster, cheaper and more accurate, they gain perspective on the particular genetic blueprint that orchestrates all activities of that organism. With this insight, they can make decisions about care, what an organism might be susceptible to in the future, what mutations might cause different diseases and how to prepare for the future.


The Wonderful Ways Artificial Intelligence Is Transforming Genomics and Gene Editing

#artificialintelligence

By 2021, consultant firm Frost & Sullivan expects that artificial intelligence (AI) systems will generate $6.7 billion in revenue from healthcare globally. One area that machine learning is significantly evolving is genomics--the study of the complete set of genes within an organism. While much attention has been paid to the implications for human health, genetic sequencing and analysis could also be ground-breaking for agriculture and animal husbandry. When researchers can sequence and analyze DNA, something that artificial intelligence systems make faster, cheaper and more accurate, they gain perspective on the particular genetic blueprint that orchestrates all activities of that organism. With this insight, they can make decisions about care, what an organism might be susceptible to in the future, what mutations might cause different diseases and how to prepare for the future.