### Artificial Intelligence Promising for Breast Cancer Metastases Detection

A deep learning algorithm can detect metastases in sections of lymph nodes from women with breast cancer; and a deep learning system (DLS) has high sensitivity and specificity for identifying diabetic retinopathy, according to two studies published online Dec. 12 in the Journal of the American Medical Association.

### Artificial intelligence promising for CA, retinopathy diagnoses

Babak Ehteshami Bejnordi, from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues compared the performance of automated deep learning algorithms for detecting metastases in hematoxylin and eosin-stained tissue sections of lymph nodes of women with breast cancer with pathologists' diagnoses in a diagnostic setting. The researchers found that the area under the receiver operating characteristic curve (AUC) ranged from 0.556 to 0.994 for the algorithms. The lesion-level, true-positive fraction achieved for the top-performing algorithm was comparable to that of the pathologist without a time constraint at a mean of 0.0125 false-positives per normal whole-slide image. Daniel Shu Wei Ting, M.D., Ph.D., from the Singapore National Eye Center, and colleagues assessed the performance of a DLS for detecting referable diabetic retinopathy and related eye diseases using 494,661 retinal images. The researchers found that the AUC of the DLS for referable diabetic retinopathy was 0.936, and sensitivity and specificity were 90.5 and 91.6 percent, respectively.

### Roche Study Shows AI Can Detect Severity of Diabetic Macular Edema BioSpace

A new study conducted by researchers from Genentech and Roche shows first-time proof that artificial intelligence can detect the severity of diabetic macular edema, which is a leading cause of blindness. On Monday, researchers from Genentech and its parent company Roche published the study, Deep Learning Predicts OCT Measures of Diabetic Macular Thickening From Color Fundus Photographs" in the journal, Investigative Ophthalmology & Visual Science. The study showed that artificial intelligence can be used to provide widespread, cost-effective eye screenings via telemedicine to assist ophthalmologists in improving vision outcomes for millions of people with diabetes who may not be getting regular eye exams. The article is the first to be published that is part of a Roche/Genentech's Ophthalmology Personalized Healthcare initiative. The initiative, Roche said in a statement, aims to combine meaningful large-scale data and AI technology to predict and prevent ocular conditions and ...

### HYPE: A High Performing NLP System for Automatically Detecting Hypoglycemia Events from Electronic Health Record Notes

Hypoglycemia is common and potentially dangerous among those treated for diabetes. Electronic health records (EHRs) are important resources for hypoglycemia surveillance. In this study, we report the development and evaluation of deep learning-based natural language processing systems to automatically detect hypoglycemia events from the EHR narratives. Experts in Public Health annotated 500 EHR notes from patients with diabetes. We used this annotated dataset to train and evaluate HYPE, supervised NLP systems for hypoglycemia detection. In our experiment, the convolutional neural network model yielded promising performance $Precision=0.96 \pm 0.03, Recall=0.86 \pm 0.03, F1=0.91 \pm 0.03$ in a 10-fold cross-validation setting. Despite the annotated data is highly imbalanced, our CNN-based HYPE system still achieved a high performance for hypoglycemia detection. HYPE could be used for EHR-based hypoglycemia surveillance and to facilitate clinicians for timely treatment of high-risk patients.