Having disrupted sleep leads to increase in brain proteins associated with Alzheimer's disease, results of a study showed Monday. "We were not surprised to find that tau levels didn't budge after just one night of disrupted sleep while amyloid levels did, because amyloid levels normally change more quickly than tau levels," Yo-El Ju, assistant professor of neurology and the lead study author, said in a statement. "I think that may lead to chronically elevated amyloid levels, which animal studies have shown lead to increased risk of amyloid plaques and Alzheimer's." "As Alzheimer's disease progresses, caregiving becomes very important," Christopher Taylor, a CDC epidemiologist who led the study team, told the news outlet at the time.
Just one night of bad sleep may lead to more of a protein linked to Alzheimer's disease building up in the brain. People with Alzheimer's disease tend to have sticky clumps of beta-amyloid protein in their brains, although the roll these plaques play in the condition is unclear. It's possible this protein helps cause the condition, or instead that the protein forms plaques in the brain in response to the disease. Now researchers have found that one night of poor sleep has a detectable effect on the levels of beta-amyloid in the brain. Ehsan Shokri-Kojori, at the National Institutes of Health in Maryland, and his team discovered this by using a radioactive tracer to measure beta-amyloid in the brains of 20 volunteers over the course of two nights.
Getting a solid night's sleep is crucial not only for feeling good the next day - there is increasing evidence that it may also protect against dementia, according to new research presented Tuesday at the Alzheimer's Association International Conference in London. Three studies by researchers at Wheaton College found significant connections between breathing disorders that interrupt sleep and the accumulation of biomarkers for Alzheimer's Disease. Treating the problems with dental appliances or CPAP machines that force air into airways could help lower the risk of dementia or slow its progress, the researchers said. People with sleep-disordered breathing experience repeated episodes of hypopnea (under breathing) and apnea (not breathing) during sleep. The most common form, Obstructive Sleep Apnea (OSA), occurs in around 3 in 10 men and 1 in 5 women, according to the Alzheimer's Association.
Just one sleepless night raises levels of a protein linked to Alzheimer's disease in the blood of young men. The finding suggests that laying down good sleep habits at an early age may help to ward off the condition. People with Alzheimer's disease have clumps of two sticky proteins – beta-amyloid and tau – in their brains. Previous research has found that one night of sleep deprivation increases beta-amyloid levels in people's brains, but less is known about the effect on tau. Jonathan Cedernaes at Uppsala University in Sweden and his colleagues invited 15 healthy young men with an average age of 22 to a sleep clinic.
Sleep is a good indicator of our overall health and well-being. Seven to nine hours of sleepis recommended to feel truly rested, but oversleeping on a regular basis could signal problems with our brain health. A study published in Neurology found people who consistently sleep more than nine hours a night are more likely to develop dementia accompanied by smaller brain volume, and poor executive function. "Participants without a high school degree who sleep for more than 9 hours each night had six times the risk of developing dementia in 10 years as compared to participants who slept for less," said Dr. Sudha Seshadri, corresponding study author, and professor of neurology at Boston University School of Medicine Alzheimer's Disease Center (BUSM) and Framingham Heart Study (FSH) senior investigator, in a statement. Previous research suggests both too little sleep and too much sleep are linked to dementia.