Babak Ehteshami Bejnordi, from the Radboud University Medical Center in Nijmegen, Netherlands, and colleagues compared the performance of automated deep learning algorithms for detecting metastases in hematoxylin and eosin-stained tissue sections of lymph nodes of women with breast cancer with pathologists' diagnoses in a diagnostic setting. The researchers found that the area under the receiver operating characteristic curve (AUC) ranged from 0.556 to 0.994 for the algorithms. The lesion-level, true-positive fraction achieved for the top-performing algorithm was comparable to that of the pathologist without a time constraint at a mean of 0.0125 false-positives per normal whole-slide image. Daniel Shu Wei Ting, M.D., Ph.D., from the Singapore National Eye Center, and colleagues assessed the performance of a DLS for detecting referable diabetic retinopathy and related eye diseases using 494,661 retinal images. The researchers found that the AUC of the DLS for referable diabetic retinopathy was 0.936, and sensitivity and specificity were 90.5 and 91.6 percent, respectively.
Machine learning has been an emerging tool for various aspects of infectious diseases including tuberculosis surveillance and detection. However, WHO provided no recommendations on using computer-aided tuberculosis detection software because of the small number of studies, methodological limitations, and limited generalizability of the findings. To quantify the generalizability of the machine-learning model, we developed a Deep Convolutional Neural Network (DCNN) model using a TB-specific CXR dataset of one population (National Library of Medicine Shenzhen No.3 Hospital) and tested it with non-TB-specific CXR dataset of another population (National Institute of Health Clinical Centers). The findings suggested that a supervised deep learning model developed by using the training dataset from one population may not have the same diagnostic performance in another population. Technical specification of CXR images, disease severity distribution, overfitting, and overdiagnosis should be examined before implementation in other settings.
The Normal Means problem plays a fundamental role in many areas of modern high-dimensional statistics, both in theory and practice. And the Empirical Bayes (EB) approach to solving this problem has been shown to be highly effective, again both in theory and practice. However, almost all EB treatments of the Normal Means problem assume that the observations are independent. In practice correlations are ubiquitous in real-world applications, and these correlations can grossly distort EB estimates. Here, exploiting theory from Schwartzman (2010), we develop new EB methods for solving the Normal Means problem that take account of unknown correlations among observations. We provide practical software implementations of these methods, and illustrate them in the context of large-scale multiple testing problems and False Discovery Rate (FDR) control. In realistic numerical experiments our methods compare favorably with other commonly-used multiple testing methods.
A group of researchers from Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School (HMS) have developed a way to train artificial intelligence to read and interpret pathology images. Scientists tested the artificial intelligence (AI) during a competition at the annual International Symposium of Biomedical Imaging, where it was tasked to look for breast cancer in images of lymph nodes. It turns out it can detect breast cancer accurately 92 percent of the time and won in two separate categories during the contest. Andrew Beck from BIDMC says they used the deep learning method, which is commonly used to train AI to recognize speech, images and objects. They fed the machine with hundreds of slides marked to indicate which parts have cancerous cells and which have normal ones.
Children with autism spectrum conditions often have trouble recognizing the emotional states of people around them -- distinguishing a happy face from a fearful face, for instance. To remedy this, some therapists use a kid-friendly robot to demonstrate those emotions and to engage the children in imitating the emotions and responding to them in appropriate ways. This type of therapy works best, however, if the robot can smoothly interpret the child's own behavior -- whether he or she is interested and excited or paying attention -- during the therapy. Researchers at the MIT Media Lab have now developed a type of personalized machine learning that helps robots estimate the engagement and interest of each child during these interactions, using data that are unique to that child. Armed with this personalized "deep learning" network, the robots' perception of the children's responses agreed with assessments by human experts, with a correlation score of 60 percent, the scientists report June 27 in Science Robotics.