Life's most valuable asset is health. Continuously understanding the state of our health and modeling how it evolves is essential if we wish to improve it. Given the opportunity that people live with more data about their life today than any other time in history, the challenge rests in interweaving this data with the growing body of knowledge to compute and model the health state of an individual continually. This dissertation presents an approach to build a personal model and dynamically estimate the health state of an individual by fusing multi-modal data and domain knowledge. The system is stitched together from four essential abstraction elements: 1. the events in our life, 2. the layers of our biological systems (from molecular to an organism), 3. the functional utilities that arise from biological underpinnings, and 4. how we interact with these utilities in the reality of daily life. Connecting these four elements via graph network blocks forms the backbone by which we instantiate a digital twin of an individual. Edges and nodes in this graph structure are then regularly updated with learning techniques as data is continuously digested. Experiments demonstrate the use of dense and heterogeneous real-world data from a variety of personal and environmental sensors to monitor individual cardiovascular health state. State estimation and individual modeling is the fundamental basis to depart from disease-oriented approaches to a total health continuum paradigm. Precision in predicting health requires understanding state trajectory. By encasing this estimation within a navigational approach, a systematic guidance framework can plan actions to transition a current state towards a desired one. This work concludes by presenting this framework of combining the health state and personal graph model to perpetually plan and assist us in living life towards our goals.
Predictive business process monitoring methods exploit historical process execution logs to generate predictions about running instances (called cases) of a business process, such as the prediction of the outcome, next activity or remaining cycle time of a given process case. These insights could be used to support operational managers in taking remedial actions as business processes unfold, e.g. shifting resources from one case onto another to ensure this latter is completed on time. A number of methods to tackle the remaining cycle time prediction problem have been proposed in the literature. However, due to differences in their experimental setup, choice of datasets, evaluation measures and baselines, the relative merits of each method remain unclear. This article presents a systematic literature review and taxonomy of methods for remaining time prediction in the context of business processes, as well as a cross-benchmark comparison of 16 such methods based on 16 real-life datasets originating from different industry domains.