A camera films Dr. Emma Fisher, an astronaut aboard what seems to be an otherwise empty International Space Station, as she floats through the facility's tangled modules just after some horrible accident. The situation looks bleak: the rest of the crew is missing, and the ISS is no longer in Earth orbit. Fisher must piece together what happened and why. Wires creep like blue veins into a centralized hub, connecting the live feed to a station-wide artificial intelligence system called "S.A.M." As the game begins, Fisher's trapped in a station module, and needs S.A.M.'s help to escape -- but moreover, S.A.M. needs her help, too.