This book is intended for busy professionals working with data of any kind: engineers, BI analysts, statisticians, operations research, AI and machine learning professionals, economists, data scientists, biologists, and quants, ranging from beginners to executives. In about 300 pages and 28 chapters it covers many new topics, offering a fresh perspective on the subject, including rules of thumb and recipes that are easy to automate or integrate in black-box systems, as well as new model-free, data-driven foundations to statistical science and predictive analytics. The approach focuses on robust techniques; it is bottom-up (from applications to theory), in contrast to the traditional top-down approach. The material is accessible to practitioners with a one-year college-level exposure to statistics and probability. The compact and tutorial style, featuring many applications with numerous illustrations, is aimed at practitioners, researchers, and executives in various quantitative fields.