Protein hormone shows promise for treating neurodegenerative disorders: U.S. study

The Japan Times 

WASHINGTON – A single injection of a fragment of a life-extending protein hormone could improve cognition in those with neurodegenerative illnesses, according to new research published Tuesday. The klotho protein was found to enhance cognitive and physical performance in aging or impaired mice, said a study carried out by scientists at the University of California, San Francisco and published in the journal Cell Reports. "With our new aging demographic, cognitive dysfunction and lack of mobility are now emerging as our biggest biomedical challenges, and there are no truly effective medical therapies for these debilitating problems," said lead author Dena Dubal. "Our findings suggest that treatment with a klotho fragment enhances brain function across the lifespan and could represent a new therapeutic strategy to boost brain resilience against neurodegenerative diseases like Alzheimer's and Parkinson's disease." But researchers said clinical studies would be necessary to determine the safety and effectiveness of injecting klotho in humans.

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