Over the past decade, the NASA Autonomous Systems and Operations (ASO) project has developed and demonstrated numerous autonomy enabling technologies employing AI techniques. Our work has employed AI in three distinct ways to enable autonomous mission operations capabilities. Crew Autonomy gives astronauts tools to assist in the performance of each of these mission operations functions. Vehicle System Management uses AI techniques to turn the astronaut's spacecraft into a robot, allowing it to operate when astronauts are not present, or to reduce astronaut workload. AI technology also enables Autonomous Robots as crew assistants or proxies when the crew are not present.